Oxidized low-density lipoprotein induces hematopoietic stem cell senescence

2013 ◽  
Vol 37 (9) ◽  
pp. 940-948 ◽  
Author(s):  
Xian-Ping Zhang ◽  
Gui-Hai Zhang ◽  
Yu-Ying Wang ◽  
Jun Liu ◽  
Qiang Wei ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cell Senescence ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Hematopoietic Stem

scholarly journals One-hundred days monitoring patients submitted to hematopoietic stem cell transplantation: Events of metabolic syndrome

2014 ◽  
Vol 23 (1) ◽  
pp. 25
Author(s):  
Maria Cláudia Bernardes Spexoto ◽  
Maria Rita Marques de Oliveira
Keyword(s):  
Metabolic Syndrome ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density Lipoprotein Cholesterol ◽  
Hematopoietic Stem

ObjectiveThis study assessed early manifestations of metabolic syndrome determinants in patients submitted to hematopoietic stem cell transplantation.MethodsTwenty-seven individuals participated in the study (20 with autologous and 7 with allogeneic hematopoietic stem cell transplantation). Anthropometric variables and biochemical indicators of lipid and glucose metabolism were determined before and 100 days after hematopoietic stem cell transplantation.ResultsThe mean total cholesterol (p=0.086), very low density lipoprotein-cholesterol (p=0.069) and triglycerides (p=0.086) of all patients did not change significantly between the two study periods, but when the patients were separated by type of hematopoietic stem cell transplantation, triglycerides and very low density lipoprotein-cholesterol were close to the critical level of significance for individuals with allogeneic hematopoietic stem cell transplantation (p=0.060) and total cholesterol was significant in individualswith autologous hematopoietic stem cell transplantation (p=0.027). Anthropometric variables did not change significantly between before and 100 days after hematopoietic stem cell transplantation.ConclusionMetabolic syndrome risk factors may be associated with lipid metabolism in the early phase of allogeneic and autologous hematopoietic stem cell transplantation.Indexing terms: Body composition. Hematopoietic stem cell transplantation. Lipids. Metabolic syndrome.

scholarly journals Biochemical and cytotoxic characteristics of an in vivo circulating oxidized low density lipoprotein (LDL-).

1994 ◽  
Vol 35 (4) ◽  
pp. 669-677
Author(s):  
H.N. Hodis ◽  
D.M. Kramsch ◽  
P. Avogaro ◽  
G. Bittolo-Bon ◽  
G. Cazzolato ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein

scholarly journals Oxidized low density lipoprotein inhibits macrophage apoptosis through activation of the PI 3-kinase/PKB pathway

2001 ◽  
Vol 42 (9) ◽  
pp. 1483-1491 ◽  
Author(s):  
Rajinder S. Hundal ◽  
Baljinder S. Salh ◽  
John W. Schrader ◽  
Antonio Gómez-Muñoz ◽  
Vincent Duronio ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Macrophage Apoptosis
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