scholarly journals Isoxazole‐Derived Aroylhydrazones and Their Dinuclear Copper(II) Complexes Show Antiproliferative Activity on Breast Cancer Cells with a Potentially Alternative Mechanism Of Action

ChemBioChem ◽  
2020 ◽  
Vol 21 (17) ◽  
pp. 2474-2486
Author(s):  
Jesica Paola Rada ◽  
Jéremy Forté ◽  
Geoffrey Gontard ◽  
Vincent Corcé ◽  
Michèle Salmain ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Mechanism Of Action ◽  
Antiproliferative Activity ◽  
Breast Cancer Cells ◽  
Alternative Mechanism ◽  
Dinuclear Copper

scholarly journals Antiproliferative activity of protein hydrolysates derived from fish by-products on human colon and breast cancer cells.

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Aikaterini Kandyliari ◽  
Jaya Prakash Golla ◽  
Ying Chen ◽  
Nikolaos Papandroulakis ◽  
Maria Kapsokefalou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Antiproliferative Activity ◽  
Breast Cancer Cells ◽  
Human Colon ◽  
Protein Hydrolysates ◽  
Sea Bream ◽  
Adenocarcinoma Cells ◽  
By Products

AbstractThe consumption of fish is encouraged in dietary guidelines because of its association with health benefits; however, fish processing generates by-products (gills, bones, skin, head), which can rise up to 50–60% of fish weight after filleting. The investigation of bioactivity of fish by-products and subsequent utilization for the development of high added-value food ingredients and/or supplements will reduce waste and create new products of high nutritional value. We studied the antiproliferative activity of fish by-product protein hydrolysates (FPH) on human colon and breast cancer cells. A total of 6 Meagres “Argirosomus Regius” (1256.45 ± 232.32g) and 16 Gilthead Sea Breams “Sparus Aurata” (403.47 ± 72.92g) were obtained by HCMR Institute in Crete, Greece. The fins, skin, bones, head, and gills were isolated, lyophilized, homogenized and stored separately at -80oC. The protein hydrolysates from each byproduct were prepared using a pH extraction method. Human colorectal adenocarcinoma cells (COLO320 cells) and human breast adenocarcinoma cells (MCF7A cells) were treated with different FPH for 48 hours, and cellular proliferation was measured using the MTT assay. Results are given as mean percentage of triplicate independent analyses. Statistical significance of growth inhibition was estimated following Wilcoxon Signed-Ranks test with α = 0.05. In COLO320 cells, FPH induced a the significant antiproliferative activity at 0.5g/L. Specifically, FPH from bones, gills and skin of Meagre showed a growth inhibition of 23.7%, 9.9% and 26.4%, respectively, after 48 h of treatment. The inhibition by the same by-products from the Gilthead Sea bream was 24.6%, 21.9% and 26.4%, respectively after 48 h. In MCF7A cells, FPH exerted a significant growth inhibition at 1g/L. The skin and fins of Meagre induced a growth inhibition of 25.5% and 39.0% respectively; the gills, skin and fins of Gilthead Sea Bream showed a growth inhibition of 28.5%, 47.1% and 39.6%, respectively, after 48 h. These values were in the same range with etoposide (reference anticancer molecule) in the concentration of 3.1μM for COLO320 cells and 50μM for MCF7A. These preliminary data suggest that certain fish by-products could represent a source of anticancer peptides and may cause growth inhibition of human cancer cells. The isolation of responsible bioactive peptides from fish byproducts and the integration of them into food supplements can have beneficial effects on human health.

Antiproliferative activity of gossypol and gossypolone on human breast cancer cells

Life Sciences ◽  
1995 ◽  
Vol 57 (1) ◽  
pp. 61-67 ◽  
Author(s):  
Nancy E. Gilbert ◽  
Jill E. O'Reilly ◽  
C.J.George Chang ◽  
Young C. Lin ◽  
Robert W. Brueggemeier
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Antiproliferative Activity ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast

Antiproliferative Activity Against MCF-7 Breast Cancer Cells by Diamino-Triazaspirodiene Antifolates

2009 ◽  
Vol 74 (3) ◽  
pp. 322-326 ◽  
Author(s):  
Xiang Ma ◽  
Renee Ser-Peng Woon ◽  
Paul Chi-Lui Ho ◽  
Wai-Keung Chui
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Antiproliferative Activity ◽  
Breast Cancer Cells ◽  
Mcf 7

Organometallic cyclic polyphenols derived from 1,2-(α-keto tri or tetra methylene) ferrocene show strong antiproliferative activity on hormone-independent breast cancer cells

2010 ◽  
Vol 39 (32) ◽  
pp. 7444 ◽  
Author(s):  
Damian Plazuk ◽  
Siden Top ◽  
Anne Vessières ◽  
Marie-Aude Plamont ◽  
Michel Huché ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Antiproliferative Activity ◽  
Breast Cancer Cells
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