scholarly journals Development of Core‐Shell Nanoparticle Drug Delivery Systems Based on Biomimetic Mineralization

ChemBioChem ◽  
2020 ◽  
Vol 21 (20) ◽  
pp. 2871-2879 ◽  
Author(s):  
Guangze Yang ◽  
Yun Liu ◽  
Song Jin ◽  
Chun‐Xia Zhao
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Core Shell ◽  
Biomimetic Mineralization ◽  
Nanoparticle Drug Delivery

Nanoparticle Drug Delivery Systems: Recent Patents and Applications in Nanomedicine

2014 ◽  
Vol 3 (2) ◽  
pp. 105-118 ◽  
Author(s):  
Pedro Martins ◽  
Daniela Rosa ◽  
Alexandra Fernandes ◽  
Pedro V. Baptista
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Nanoparticle Drug Delivery

scholarly journals Micro and nanoparticle drug delivery systems for preventing allotransplant rejection

2015 ◽  
Vol 160 (1) ◽  
pp. 24-35 ◽  
Author(s):  
James D. Fisher ◽  
Abhinav P. Acharya ◽  
Steven R. Little
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Nanoparticle Drug Delivery

scholarly journals Nanoparticle Drug Delivery Systems for α-Mangostin

2020 ◽  
Vol Volume 13 ◽  
pp. 23-36 ◽  
Author(s):  
Nasrul Wathoni ◽  
Agus Rusdin ◽  
Keiichi Motoyama ◽  
I Made Joni ◽  
Ronny Lesmana ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Nanoparticle Drug Delivery

scholarly journals Active Targeting Strategies Using Biological Ligands for Nanoparticle Drug Delivery Systems

Cancers ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 640 ◽  
Author(s):  
Jihye Yoo ◽  
Changhee Park ◽  
Gawon Yi ◽  
Donghyun Lee ◽  
Heebeom Koo
Keyword(s):  
Drug Delivery ◽  
Surface Modification ◽  
Small Molecules ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Active Targeting ◽  
Target Cells ◽  
Specific Receptors ◽  
Nanoparticle Drug Delivery

Targeting nanoparticle (NP) carriers to sites of disease is critical for their successful use as drug delivery systems. Along with optimization of physicochemical properties, researchers have focused on surface modification of NPs with biological ligands. Such ligands can bind specific receptors on the surface of target cells. Furthermore, biological ligands can facilitate uptake of modified NPs, which is referred to as ‘active targeting’ of NPs. In this review, we discuss recent applications of biological ligands including proteins, polysaccharides, aptamers, peptides, and small molecules for NP-mediated drug delivery. We prioritized studies that have demonstrated targeting in animals over in vitro studies. We expect that this review will assist biomedical researchers working with NPs for drug delivery and imaging.

scholarly journals Primary biocompatibility tests of poly(lactide-co-glycolide)-(poly-L-orithine/fucoidan) core–shell nanocarriers

2018 ◽  
Vol 5 (7) ◽  
pp. 180320 ◽  
Author(s):  
Duanhua Cai ◽  
Jingqian Fan ◽  
Shibin Wang ◽  
Ruimin Long ◽  
Xia Zhou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Methylene Chloride ◽  
Drug Carrier ◽  
Delivery Systems ◽  
Core Shell ◽  
Layer By Layer ◽  
Shell Nanoparticles ◽  
Uniform Size ◽  
Covalent Bonds

Layer-by-layer (LbL) self-assembly is the technology used in intermolecular static electricity, hydrogen bonds, covalent bonds and other polymer interactions during film assembling. This technology has been widely studied in the drug carrier field. Given their use in drug delivery systems, the biocompatibility of these potential compounds should be addressed. In this work, the primary biocompatibility of poly(lactide-co-glycolide)-(poly-L-orithine/fucoidan) [PLGA-(PLO/fucoidan)] core–shell nanoparticles (NPs) was investigated. Atomic force microscopy revealed the PLGA-(PLO/Fucoidan) 4 NPs to be spherical, with a uniform size distribution and a smooth surface, and the NPs were stable in physiological saline. The residual amount of methylene chloride was further determined by headspace gas chromatography, in which the organic solvent can be volatilized during preparation. Furthermore, cell viability, acridine orange/ethidium bromide staining, haemolysis and mouse systemic toxicity were all assessed to show that PLGA-(PLO/fucoidan) 4 NPs were biocompatible with cells and mice. Therefore, these NPs are expected to have potential applications in future drug delivery systems.

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