scholarly journals Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019‐nCoV

ChemBioChem ◽  
2020 ◽  
Vol 21 (5) ◽  
pp. 730-738 ◽  
Author(s):  
Jared S. Morse ◽  
Tyler Lalonde ◽  
Shiqing Xu ◽  
Wenshe Ray Liu
Keyword(s):  
Respiratory Infections ◽  
Treatment Options ◽  
Acute Respiratory Infections ◽  
The Past ◽  
Prevention And Treatment ◽  
Severe Acute Respiratory Infections

scholarly journals Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019-nCoV

2020 ◽  
Author(s):  
Jared S. Morse ◽  
Tyler Lalonde ◽  
Shiqing Xu ◽  
Wenshe Liu
Keyword(s):  
Patient Outcomes ◽  
Drug Targets ◽  
Respiratory Infections ◽  
Treatment Options ◽  
Cell Infection ◽  
Drug Candidates ◽  
The Past ◽  
Strong Homology ◽  
Macrocyclic Peptides ◽  
Severe Acute Respiratory Infections

With the current trajectory of the 2019-nCoV outbreak unknown, public health and medicinal measures will both be needed to contain spreading of the virus and to optimize patient outcomes. While little is known about the virus, an examination of the genome sequence shows strong homology with its more well-studied cousin, SARS-CoV. The spike protein used for host cell infection shows key nonsynonymous mutations which may hamper efficacy of previously developed therapeutics but remains a viable target for the development of biologics and macrocyclic peptides. Other key drug targets, including RdRp and 3CLpro, share a strikingly high (>95%) homology to SARS-CoV. Herein, we suggest 4 potential drug candidates (an ACE2-based peptide, remdesivir, 3CLpro-1 and a novel vinylsulfone protease inhibitor) that can be used to treat patients suffering with the 2019-nCoV. We also summarize previous efforts into drugging these targets and hope to help in the development of broad spectrum anti-coronaviral agents for future epidemics.

scholarly journals Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019-nCoV

2020 ◽  
Author(s):  
Jared S. Morse ◽  
Tyler Lalonde ◽  
Shiqing Xu ◽  
Wenshe Liu
Keyword(s):  
Patient Outcomes ◽  
Drug Targets ◽  
Respiratory Infections ◽  
Treatment Options ◽  
Cell Infection ◽  
Drug Candidates ◽  
The Past ◽  
Strong Homology ◽  
Macrocyclic Peptides ◽  
Severe Acute Respiratory Infections

With the current trajectory of the 2019-nCoV outbreak unknown, public health and medicinal measures will both be needed to contain spreading of the virus and to optimize patient outcomes. While little is known about the virus, an examination of the genome sequence shows strong homology with its more well-studied cousin, SARS-CoV. The spike protein used for host cell infection shows key nonsynonymous mutations which may hamper efficacy of previously developed therapeutics but remains a viable target for the development of biologics and macrocyclic peptides. Other key drug targets, including RdRp and 3CLpro, share a strikingly high (>95%) homology to SARS-CoV. Herein, we suggest 4 potential drug candidates (an ACE2-based peptide, remdesivir, 3CLpro-1 and a novel vinylsulfone protease inhibitor) that can be used to treat patients suffering with the 2019-nCoV. We also summarize previous efforts into drugging these targets and hope to help in the development of broad spectrum anti-coronaviral agents for future epidemics.

scholarly journals Mesenchymal Stem Cells: The Secret Children’s Weapons against the SARS-CoV-2 Lethal Infection

2021 ◽  
Vol 11 (4) ◽  
pp. 1696
Author(s):  
Mario Giosuè Balzanelli ◽  
Pietro Distratis ◽  
Orazio Catucci ◽  
Angelo Cefalo ◽  
Rita Lazzaro ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Respiratory Infections ◽  
Acute Respiratory Infections ◽  
Unusual Event ◽  
Inflammatory Processes ◽  
Life Threatening ◽  
Severe Acute Respiratory Infections ◽  
Novel Coronavirus

Due to the promising effects of mesenchymal stem cells (MSCs) in the treatment of various diseases, this commentary aimed to focus on the auxiliary role of MSCs to reduce inflammatory processes of acute respiratory infections caused by the 2019 novel coronavirus (COVID-19). Since early in 2020, COVID-19, a consequence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly affected millions of people world-wide. The SARS-CoV-2 infection in children appears to be an unusual event. Despite the high number of affected adult and elderly, children and adolescents remained low in amounts, and marginally touched. Based on the promising role of cell therapy and regenerative medicine approaches in the treatment of several life-threatening diseases, it seems that applying MSCs cell-based approaches can also be a hopeful strategy for improving subjects with severe acute respiratory infections caused by COVID-19.

scholarly journals Bocavirus in Patients With Severe Acute Respiratory Infections: Is it a Real Pathogen?

2015 ◽  
Vol 2 (suppl_1) ◽  
Author(s):  
Jorge Cortes ◽  
Liliana Diaz ◽  
Sandra Gomez ◽  
Alejandra Guarnizo ◽  
Tatiana Olarte ◽  
...  
Keyword(s):  
Respiratory Infections ◽  
Acute Respiratory Infections ◽  
Severe Acute Respiratory Infections

scholarly journals P1-105 Incidence of severe acute respiratory infections (SARI) and deaths associated with influenza

2011 ◽  
Vol 65 (Suppl 1) ◽  
pp. A96-A96
Author(s):  
A. Cabello ◽  
M. V. Horoch ◽  
L. Bobadilla ◽  
C. Vazquez ◽  
M. Samudio ◽  
...  
Keyword(s):  
Respiratory Infections ◽  
Acute Respiratory Infections ◽  
Severe Acute Respiratory Infections

scholarly journals Comparison of the nasopharynx microbiome between influenza and non-influenza cases of severe acute respiratory infections: A pilot study

2018 ◽  
Vol 1 (6) ◽  
pp. e47 ◽  
Author(s):  
Luiz Gustavo dos Anjos Borges ◽  
Adriana Giongo ◽  
Leandro de Mattos Pereira ◽  
Fernanda J. Trindade ◽  
Tatiana Schäffer Gregianini ◽  
...  
Keyword(s):  
Pilot Study ◽  
Respiratory Infections ◽  
Acute Respiratory Infections ◽  
Severe Acute Respiratory Infections

scholarly journals Etiology of Severe Acute Respiratory Infections, Bangladesh, 2017

2021 ◽  
Vol 27 (1) ◽  
pp. 324-326
Author(s):  
Md R. Rahaman ◽  
Karen A. Alroy ◽  
Chris A. Van Beneden ◽  
Michael S. Friedman ◽  
Erin D. Kennedy ◽  
...  
Keyword(s):  
Respiratory Infections ◽  
Acute Respiratory Infections ◽  
Severe Acute Respiratory Infections

scholarly journals Use of Ambulance Dispatch Calls for Surveillance of Severe Acute Respiratory Infections

2020 ◽  
Vol 26 (1) ◽  
pp. 148-150 ◽  
Author(s):  
Susana Monge ◽  
Janneke Duijster ◽  
Geert Jan Kommer ◽  
Jan van de Kassteele ◽  
Gé A. Donker ◽  
...  
Keyword(s):  
Respiratory Infections ◽  
Acute Respiratory Infections ◽  
Ambulance Dispatch ◽  
Severe Acute Respiratory Infections
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