scholarly journals In Vivo Expression of Genetic Information from Phosphoramidate–DNA

ChemBioChem ◽  
2020 ◽  
Vol 21 (1-2) ◽  
pp. 272-278 ◽  
Author(s):  
Hoai Nguyen ◽  
Mikhail Abramov ◽  
Elena Eremeeva ◽  
Piet Herdewijn
Keyword(s):  
Genetic Information ◽  
In Vivo Expression

scholarly journals In Vivo Expression of Reprogramming Factor OCT4 Ameliorates Myelination Deficits and Induces Striatal Neuroprotection in Huntington’s Disease

Genes ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 712
Author(s):  
Ji-Hea Yu ◽  
Bae-Geun Nam ◽  
Min-Gi Kim ◽  
Soonil Pyo ◽  
Jung-Hwa Seo ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Cell Fate ◽  
Gabaergic Neurons ◽  
Oligodendrocyte Progenitor Cells ◽  
Adeno Associated Virus ◽  
In Vivo Expression ◽  
Transcription Factor 4 ◽  
Phosphate Buffered Saline

White matter atrophy has been shown to precede the massive loss of striatal GABAergic neurons in Huntington’s disease (HD). This study investigated the effects of in vivo expression of reprogramming factor octamer-binding transcription factor 4 (OCT4) on neural stem cell (NSC) niche activation in the subventricular zone (SVZ) and induction of cell fate specific to the microenvironment of HD. R6/2 mice randomly received adeno-associated virus 9 (AAV9)-OCT4, AAV9-Null, or phosphate-buffered saline into both lateral ventricles at 4 weeks of age. The AAV9-OCT4 group displayed significantly improved behavioral performance compared to the control groups. Following AAV9-OCT4 treatment, the number of newly generated NSCs and oligodendrocyte progenitor cells (OPCs) significantly increased in the SVZ, and the expression of OPC-related genes and glial cell-derived neurotrophic factor (GDNF) significantly increased. Further, amelioration of myelination deficits in the corpus callosum was observed through electron microscopy and magnetic resonance imaging, and striatal DARPP32+ GABAergic neurons significantly increased in the AAV9-OCT4 group. These results suggest that in situ expression of the reprogramming factor OCT4 in the SVZ induces OPC proliferation, thereby attenuating myelination deficits. Particularly, GDNF released by OPCs seems to induce striatal neuroprotection in HD, which explains the behavioral improvement in R6/2 mice overexpressing OCT4.

scholarly journals Transfer of the α5(IV) Collagen Chain Gene to Smooth Muscle Restores in Vivo Expression of the α6(IV) Collagen Chain in a Canine Model of Alport Syndrome

2003 ◽  
Vol 162 (3) ◽  
pp. 873-885 ◽  
Author(s):  
Scott J. Harvey ◽  
Keqin Zheng ◽  
Barbara Jefferson ◽  
Peter Moak ◽  
Yoshikazu Sado ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Alport Syndrome ◽  
Canine Model ◽  
Chain Gene ◽  
In Vivo Expression ◽  
Collagen Chain

PPARγ in coronary atherosclerosis: In vivo expression pattern and correlations with hyperlipidemic status and statin treatment

2011 ◽  
Vol 218 (2) ◽  
pp. 479-485 ◽  
Author(s):  
Angela Pucci ◽  
Luisa Formato ◽  
Maruska Muscio ◽  
Elvis Brscic ◽  
Stefania Pizzimenti ◽  
...  
Keyword(s):  
Expression Pattern ◽  
Coronary Atherosclerosis ◽  
Statin Treatment ◽  
In Vivo Expression

scholarly journals In vivo expression of interleukin-8, and regulated on activation, normal, T-cell expressed, and secreted, by human germinal centre B lymphocytes

Immunology ◽  
2003 ◽  
Vol 110 (3) ◽  
pp. 296-303 ◽  
Author(s):  
Jennifer C. Sims-Mourtada ◽  
Liliana Guzman-Rojas ◽  
Roberto Rangel ◽  
Dat X. Nghiem ◽  
Stephen E. Ullrich ◽  
...  
Keyword(s):  
T Cell ◽  
B Lymphocytes ◽  
Germinal Centre ◽  
Interleukin 8 ◽  
In Vivo Expression

In vitro and in vivo expression of a nephritogenic Ig heavy chain determinant: Pathogenic autoreactivity requires permissive light chains

2001 ◽  
Vol 79 (3) ◽  
pp. 222-230 ◽  
Author(s):  
Brenda G Cooperstone ◽  
Mohammed M Rahman ◽  
Earl H Rudolph ◽  
Mary H Foster
Keyword(s):  
Heavy Chain ◽  
Light Chains ◽  
In Vivo Expression ◽  
Ig Heavy Chain
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