scholarly journals Phototemtide A, a Cyclic Lipopeptide Heterologously Expressed from Photorhabdus temperata Meg1, Shows Selective Antiprotozoal Activity

ChemBioChem ◽  
2020 ◽  
Vol 21 (9) ◽  
pp. 1288-1292
Author(s):  
Lei Zhao ◽  
Tien Duy Vo ◽  
Marcel Kaiser ◽  
Helge B. Bode
Keyword(s):  
Antiprotozoal Activity ◽  
Cyclic Lipopeptide ◽  
Photorhabdus Temperata

Antiprotozoal Activity Of Some Egyptian Plants

Planta Medica ◽  
2016 ◽  
Vol 82 (05) ◽  
Author(s):  
AA Zaki ◽  
Z Ali ◽  
YA El-Amier ◽  
A Ashour ◽  
BM Oluwasesan ◽  
...  
Keyword(s):  
Antiprotozoal Activity

Diterpenoids from Astrodaucus orientalis (L.) Drude - Antiprotozoal activity

2017 ◽  
Author(s):  
S Nejad Ebrahimi ◽  
H Hashempour ◽  
F Herfati ◽  
H Valizadeh ◽  
F Mahmoudi-Kordi ◽  
...  
Keyword(s):  
Antiprotozoal Activity

Nomenclature Abstract for Photorhabdus temperata tasmaniensis Tailliez et al. 2010.

2003 ◽  
Author(s):  
Charles Thomas Parker ◽  
Kara Mannor ◽  
George M Garrity
Keyword(s):  
Photorhabdus Temperata

Review of Theoretical Models to Study Natural Products with Antiprotozoal Activity

2017 ◽  
Vol 18 (5) ◽  
pp. 605-616 ◽  
Author(s):  
Miguel Herrera-Rueda ◽  
Gabriel Navarrete-Vázquez ◽  
Francisco Aguirre-Crespo ◽  
Maria Maldonado-Velazquez ◽  
Jorge Vergara-Galicia ◽  
...  
Keyword(s):  
Natural Products ◽  
Theoretical Models ◽  
Antiprotozoal Activity

Iturin: cyclic lipopeptide with multifunction biological potential

2021 ◽  
pp. 1-13
Author(s):  
Chunpeng Wan ◽  
Xiaoyuan Fan ◽  
Zaixiang Lou ◽  
Hongxin Wang ◽  
Ahmed Olatunde ◽  
...  
Keyword(s):  
Cyclic Lipopeptide ◽  
Biological Potential

scholarly journals Antiprotozoal and Antitumor Activity of Natural Polycyclic Endoperoxides: Origin, Structures and Biological Activity

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 686
Author(s):  
Valery M. Dembitsky ◽  
Ekaterina Ermolenko ◽  
Nick Savidov ◽  
Tatyana A. Gloriozova ◽  
Vladimir V. Poroikov
Keyword(s):  
Antitumor Activity ◽  
Confidence Level ◽  
Clinical Medicine ◽  
Marine Invertebrates ◽  
Antiprotozoal Activity ◽  
Strong Activity ◽  
The Third ◽  
Intracellular Parasites ◽  
Antitumor Properties ◽  
Pharmacological Potential

Polycyclic endoperoxides are rare natural metabolites found and isolated in plants, fungi, and marine invertebrates. The purpose of this review is a comparative analysis of the pharmacological potential of these natural products. According to PASS (Prediction of Activity Spectra for Substances) estimates, they are more likely to exhibit antiprotozoal and antitumor properties. Some of them are now widely used in clinical medicine. All polycyclic endoperoxides presented in this article demonstrate antiprotozoal activity and can be divided into three groups. The third group includes endoperoxides, which show weak antiprotozoal activity with a reliability of up to 70%, and this group includes only 1.1% of metabolites. The second group includes the largest number of endoperoxides, which are 65% and show average antiprotozoal activity with a confidence level of 70 to 90%. Lastly, the third group includes endoperoxides, which are 33.9% and show strong antiprotozoal activity with a confidence level of 90 to 99.6%. Interestingly, artemisinin and its analogs show strong antiprotozoal activity with 79 to 99.6% confidence against obligate intracellular parasites which belong to the genera Plasmodium, Toxoplasma, Leishmania, and Coccidia. In addition to antiprotozoal activities, polycyclic endoperoxides show antitumor activity in the proportion: 4.6% show weak activity with a reliability of up to 70%, 65.6% show an average activity with a reliability of 70 to 90%, and 29.8% show strong activity with a reliability of 90 to 98.3%. It should also be noted that some polycyclic endoperoxides, in addition to antiprotozoal and antitumor properties, show other strong activities with a confidence level of 90 to 97%. These include antifungal activity against the genera Aspergillus, Candida, and Cryptococcus, as well as anti-inflammatory activity. This review provides insights on further utilization of polycyclic endoperoxides by medicinal chemists, pharmacologists, and the pharmaceutical industry.

scholarly journals Cyclic Lipopeptides with Herbicidal and Insecticidal Activities Produced by Bacillus clausii DTM1

2015 ◽  
Vol 10 (12) ◽  
pp. 1934578X1501001 ◽  
Author(s):  
Da-Le Guo ◽  
Bo Wan ◽  
Shi-Ji Xiao ◽  
Sarah Allen ◽  
Yu-Cheng Gu ◽  
...  
Keyword(s):  
Methyl Ester ◽  
Natural Product ◽  
Fermentation Broth ◽  
Cyclic Lipopeptides ◽  
Bacillus Clausii ◽  
Cyclic Lipopeptide ◽  
Lipopeptide Biosurfactants ◽  
First Time ◽  
Insecticidal Activities

Seven cyclic lipopeptide biosurfactants (1–7) were isolated for the first time from the fermentation broth of endophytic Bacillus clausii DTM1 and were identified as anteisoC13[Val7] surfactin-(L-Glu)-O-methyl-ester (1), anteisoC12[Val7] surfactin (2), anteisoC15[Val7] surfactin (3), isoC14[Leu7] surfactin (4), anteisoC12[Leu7] surfactin (5), nC13[Leu7] surfactin (6), and anteisoC14[Leu7] surfactin-(L-Glu)-O-methyl-ester (7); 1 has not been isolated before as a natural product from any source. Plate-based herbicide and insecticide bioassays showed that all compounds exhibited interesting insecticidal and herbicidal activities.

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