Synthesis of Cyclic Sulfite Diesters and their Evaluation as Sulfur Dioxide (SO 2 ) Donors

ChemBioChem ◽  
2020 ◽  
Vol 21 (8) ◽  
pp. 1201-1205
Author(s):  
Satish R. Malwal ◽  
Kundansingh A. Pardeshi ◽  
Harinath Chakrapani
Keyword(s):  
Sulfur Dioxide ◽  
Cyclic Sulfite

scholarly journals Synthesis and Evaluation of Cyclic Sulfite Diesters as Sulfur Dioxide (SO2) Donors

2019 ◽  
Author(s):  
Satish Malwal ◽  
Kundansinghsingh Pardeshi ◽  
Harinath Chakrapani
Keyword(s):  
Sulfur Dioxide ◽  
Food Industry ◽  
Sodium Bisulfite ◽  
Cell Permeability ◽  
Hydrated Form ◽  
New Class ◽  
Nucleophilic Displacement ◽  
Cyclic Sulfite ◽  
Lack Of Control ◽  
Release Profiles

<div>Although sulfur dioxide (SO<sub>2</sub>) finds widespread use in the food industry as its hydrated form, sulfite, a number of aspects of SO<sub>2 </sub>biology remain to be completely understood. Among the tools available for intracellular enhancement of SO<sub>2</sub>, most suffer from poor cell permeability and a lack of control over SO<sub>2</sub> release. We report 1,2-cyclic sulfite diesters as a new class of reliable SO<sub>2 </sub>donors that dissociate in buffer through a nucleophilic displacement to produce SO<sub>2 </sub>with tuneable release profiles. We provide data in support of the suitability of these SO<sub>2 </sub>donors to enhance intracellular levels of SO<sub>2 </sub>at an efficiency superior to sodium bisulfite, the most commonly used SO<sub>2</sub> donor for cellular studies.</div>

scholarly journals Synthesis and Evaluation of Cyclic Sulfite Diesters as Sulfur Dioxide (SO2) Donors

2019 ◽  
Author(s):  
Satish Malwal ◽  
Kundansinghsingh Pardeshi ◽  
Harinath Chakrapani
Keyword(s):  
Sulfur Dioxide ◽  
Food Industry ◽  
Sodium Bisulfite ◽  
Cell Permeability ◽  
Hydrated Form ◽  
New Class ◽  
Nucleophilic Displacement ◽  
Cyclic Sulfite ◽  
Lack Of Control ◽  
Release Profiles

<div>Although sulfur dioxide (SO<sub>2</sub>) finds widespread use in the food industry as its hydrated form, sulfite, a number of aspects of SO<sub>2 </sub>biology remain to be completely understood. Among the tools available for intracellular enhancement of SO<sub>2</sub>, most suffer from poor cell permeability and a lack of control over SO<sub>2</sub> release. We report 1,2-cyclic sulfite diesters as a new class of reliable SO<sub>2 </sub>donors that dissociate in buffer through a nucleophilic displacement to produce SO<sub>2 </sub>with tuneable release profiles. We provide data in support of the suitability of these SO<sub>2 </sub>donors to enhance intracellular levels of SO<sub>2 </sub>at an efficiency superior to sodium bisulfite, the most commonly used SO<sub>2</sub> donor for cellular studies.</div>

The Determination of Sulfur Dioxide-Correction

1917 ◽  
Vol 9 (12) ◽  
pp. 1148-1148
Author(s):  
James Withrow
Keyword(s):  
Sulfur Dioxide
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