scholarly journals Towards Light‐Activated Ruthenium–Arene (RAPTA‐Type) Prodrug Candidates

ChemBioChem ◽  
2019 ◽  
Vol 20 (22) ◽  
pp. 2876-2882 ◽  
Author(s):  
Anna K. Renfrew ◽  
Johannes Karges ◽  
Rosario Scopelliti ◽  
Felix D. Bobbink ◽  
Patrycja Nowak‐Sliwinska ◽  
...  
Keyword(s):  
Ruthenium Arene

Discovery and Investigation of Anticancer Ruthenium–Arene Schiff-Base Complexes via Water-Promoted Combinatorial Three-Component Assembly

2014 ◽  
Vol 57 (14) ◽  
pp. 6043-6059 ◽  
Author(s):  
Mun Juinn Chow ◽  
Cynthia Licona ◽  
Daniel Yuan Qiang Wong ◽  
Giorgia Pastorin ◽  
Christian Gaiddon ◽  
...  
Keyword(s):  
Schiff Base ◽  
Schiff Base Complexes ◽  
Component Assembly ◽  
Ruthenium Arene

Synthesis, characterization, anticancer and antimicrobial study of arene ruthenium(II) complexes with 1,2,4-triazole ligands containing an α-diimine moiety

2018 ◽  
Vol 73 (3-4) ◽  
pp. 167-178 ◽  
Author(s):  
Joel M. Gichumbi ◽  
Holger B. Friedrich ◽  
Bernard Omondi ◽  
Geraldine G. Lazarus ◽  
Moganavelli Singh ◽  
...  
Keyword(s):  
Cell Line ◽  
Colorectal Adenocarcinoma ◽  
Bidentate Ligand ◽  
Reference Drug ◽  
Mononuclear Complexes ◽  
Counter Ion ◽  
Elemental Analyses ◽  
Ruthenium Arene ◽  
Cl Atom ◽  
C Nmr

AbstractThe reaction of the ruthenium arene dimers [(η6-arene)Ru(μ-Cl)Cl]2(where arene=benzene orp-cymene) with the ligands 4-benzylidene-3,5-di(2′-pyridyl)-4-amino-1,2,4-triazole (L1), 2-methoxybenzylidene-3,5-di(2′-pyridyl)-4-amino-1,2,4-triazole (L2), 4-methylbenzylidene-3,5-di(2′-pyridyl)-4-amino-1,2,4-triazole (L3) and indole-3-carbaldehyde-3,5-di(2′-pyridyl)-4-amino-1,2,4-triazole (L4) in a 1:2 ratio gives the new complexes [(η6-arene)RuCl(L)]+[arene=C6H6(with L=L1(1), L2(3), L4(7), with PF6−as a counter ion, and L4(6), with Cl−as a counter ion) orp-cymene with L=L1(2), L2(4), L3(5), L4(8) with PF6−as a counter ion]. All complexes were fully characterized using1H and13C NMR, elemental analyses, UV/Vis and IR spectroscopy. The single crystal X-ray structures of ligandL2and complex1have been determined. The structure of1has the Ru atom coordinated with the arene group and to theN,N′-bidentate ligand and to the Cl atom. The arene group occupies the apex, while the ligand and the Cl atom are at the base of a pseudo-octahedral three-legged piano stool. The cytotoxicity of these mononuclear complexes was established in the human epithelial colorectal adenocarcinoma cell line (Caco-2) and for selectivity in the non-cancerous human embryonic kidney cell line (HEK293), using 5-fluorouracil (5-FU) as the reference anticancer drug. Compounds1and7were relatively inactive toward the Caco-2 tumor cells (IC50>200), while complexes2–5showed moderate anti-proliferative properties (IC50>100–200). Compound6, however, displayed better anti-proliferative properties with an IC50value lower than that of the reference drug, 5-FU, and was therefore further investigated for its antimicrobial activity against six Gram-positive and four Gram-negative bacteria.

Ruthenium Arene Anticancer Complexes

2006 ◽  
pp. 39-64 ◽  
Author(s):  
Michael Melchart ◽  
Peter J. Sadler
Keyword(s):  
Anticancer Complexes ◽  
Ruthenium Arene

Ruthenium dendrimers against acute promyelocytic leukemia: in vitrostudies on HL-60 cells

2019 ◽  
Vol 11 (14) ◽  
pp. 1741-1756 ◽  
Author(s):  
Sylwia Michlewska ◽  
Maksim Ionov ◽  
Marta Maroto-Díaz ◽  
Aleksandra Szwed ◽  
Aliaksei Ihnatsyeu-Kachan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Promyelocytic Leukemia ◽  
Water Soluble ◽  
Carbosilane Dendrimers ◽  
Normal Cells ◽  
Antitumor Potential ◽  
Antitumor Properties ◽  
Ruthenium Arene

Coordination of ruthenium arene fragments on carbosilane dendrimers’ surface greatly increases their antitumor properties. Newly synthetized ruthenium dendrimers are water-soluble, monodisperse and stable. Since carbosilane dendrimers are good carriers of drugs and genes, the presence of ruthenium in their structure makes them promising candidates for new drug delivery systems with improved antitumor potential. Carbosilane ruthenium dendrimers are more toxic to cancer cells than normal cells. Results of several in vitro studies applied here indicate that carbosilane ruthenium dendrimers induce apoptosis in promyelocytic leukemia HL-60 cells.

Synthesis and Catalytic Evaluation in Olefin Metathesis of a Second-Generation Homobimetallic Ruthenium–Arene Complex Bearing a Vinylidene Ligand

2011 ◽  
Vol 30 (10) ◽  
pp. 2730-2738 ◽  
Author(s):  
Yannick Borguet ◽  
Xavier Sauvage ◽  
Guillermo Zaragoza ◽  
Albert Demonceau ◽  
Lionel Delaude
Keyword(s):  
Olefin Metathesis ◽  
Second Generation ◽  
Arene Complex ◽  
Ruthenium Arene

Ruthenium–arene complexes bearing imidazol(in)ium-2-dithiocarboxylate ligands: Evaluation of their catalytic activity in the synthesis of enol esters

2009 ◽  
Vol 694 (25) ◽  
pp. 4049-4055 ◽  
Author(s):  
Quentin Willem ◽  
François Nicks ◽  
Xavier Sauvage ◽  
Lionel Delaude ◽  
Albert Demonceau
Keyword(s):  
Catalytic Activity ◽  
Arene Complexes ◽  
Enol Esters ◽  
Ruthenium Arene

Synthesis, Kinetics, and Stereochemistry of P−C Bond Breaking and P−C Bond Making Reactions:  Ruthenium−Arene Binap Chemistry

2001 ◽  
Vol 20 (14) ◽  
pp. 2990-2997 ◽  
Author(s):  
Tilmann J. Geldbach ◽  
Paul S. Pregosin ◽  
Mauro Bassetti
Keyword(s):  
Bond Breaking ◽  
Ruthenium Arene

scholarly journals Ruthenium arene complexes with triphenylphosphane ligands: cytotoxicity towards pancreatic cancer cells, interaction with model proteins, and effect of ethacrynic acid substitution

2017 ◽  
Vol 41 (23) ◽  
pp. 14574-14588 ◽  
Author(s):  
Lorenzo Biancalana ◽  
Alessandro Pratesi ◽  
Federica Chiellini ◽  
Stefano Zacchini ◽  
Tiziana Funaioli ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Ethacrynic Acid ◽  
Arene Complexes ◽  
Pancreatic Cancer Cells ◽  
Ruthenium Arene

The anticancer behaviour of Ru arene complexes can be tuned by an appropriate choice of the site and linkage of the bioactive group to the phosphane ligand.

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