2′-O ,4′-C -Methylene-Bridged Nucleic Acids Stabilize Metal-Mediated Base Pairing in a DNA Duplex

ChemBioChem ◽  
2018 ◽  
Vol 19 (22) ◽  
pp. 2372-2379 ◽  
Author(s):  
Osamu Nakagawa ◽  
Akane Fujii ◽  
Yuki Kishimoto ◽  
Yusuke Nakatsuji ◽  
Natsumi Nozaki ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Base Pairing ◽  
Dna Duplex

scholarly journals Front Cover: 2′-O ,4′-C -Methylene-Bridged Nucleic Acids Stabilize Metal-Mediated Base Pairing in a DNA Duplex (ChemBioChem 22/2018)

ChemBioChem ◽  
2018 ◽  
Vol 19 (22) ◽  
pp. 2321-2321
Author(s):  
Osamu Nakagawa ◽  
Akane Fujii ◽  
Yuki Kishimoto ◽  
Yusuke Nakatsuji ◽  
Natsumi Nozaki ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Base Pairing ◽  
Dna Duplex ◽  
Front Cover

Studies on the thymine–mercury–thymine base pairing in parallel and anti-parallel DNA duplexes

2015 ◽  
Vol 39 (11) ◽  
pp. 8752-8762 ◽  
Author(s):  
Gaofeng Liu ◽  
Zhiwen Li ◽  
Junfei Zhu ◽  
Yang Liu ◽  
Ying Zhou ◽  
...  
Keyword(s):  
Dna Duplexes ◽  
Base Pairing ◽  
Dna Duplex ◽  
Base Pairs ◽  
Thermal Stabilities

Parallel and anti-parallel T–Hg–T base pairs have different thermal stabilities and conformational influences on DNA duplex structures.

scholarly journals Synthesis of phosphoramidites of isoGNA, an isomer of glycerol nucleic acid

2014 ◽  
Vol 10 ◽  
pp. 2131-2138 ◽  
Author(s):  
Keunsoo Kim ◽  
Venkateshwarlu Punna ◽  
Phaneendrasai Karri ◽  
Ramanarayanan Krishnamurthy
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Structural Unit ◽  
Easy Access ◽  
Alternative Route ◽  
Base Pairing ◽  
Limited Base ◽  
Glycerol Nucleic Acid ◽  
Adenine Derivative

IsoGNA, an isomer of glycerol nucleic acid GNA, is a flexible (acyclic) nucleic acid with bases directly attached to its linear backbone. IsoGNA exhibits (limited) base-pairing properties which are unique compared to other known flexible nucleic acids. Herein, we report on the details of the preparation of isoGNA phosphoramidites and an alternative route for the synthesis of the adenine derivative. The synthetic improvements described here enable an easy access to isoGNA and allows for the further exploration of this structural unit in oligonucleotide chemistry thereby spurring investigations of its usefulness and applicability.

scholarly journals Making Molecules with Clay: Layered Double Hydroxides, Pentopyranose Nucleic Acids and the Origin of Life

Life ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 19 ◽  
Author(s):  
Harold Bernhardt
Keyword(s):  
Nucleic Acids ◽  
Lipid Bilayers ◽  
Information Transfer ◽  
Prebiotic Synthesis ◽  
Base Pairing ◽  
Phosphate Backbone ◽  
The Origin Of Life ◽  
Double Hydroxide ◽  
Double Hydroxides ◽  
Purine Pyrimidine

A mixture of sugar diphosphates is produced in reactions between small aldehyde phosphates catalysed by layered double hydroxide (LDH) clays under plausibly prebiotic conditions. A subset of these, pentose diphosphates, constitute the backbone subunits of nucleic acids capable of base pairing, which is not the case for the other products of these LDH-catalysed reactions. Not only that, but to date no other polymer found capable of base pairing—and therefore information transfer—has a backbone for which its monomer subunits have a plausible prebiotic synthesis, including the ribose-5-phosphate backbone subunit of RNA. Pentose diphosphates comprise the backbone monomers of pentopyranose nucleic acids, some of the strongest base pairing systems so far discovered. We have previously proposed that the first base pairing interactions were between purine nucleobase precursors, and that these were weaker and less specific than standard purine-pyrimidine interactions. We now propose that the inherently stronger pairing of pentopyranose nucleic acids would have compensated for these weaker interactions, and produced an informational polymer capable of undergoing nonenzymatic replication. LDH clays might also have catalysed the synthesis of the purine nucleobase precursors, and the polymerization of pentopyranose nucleotide monomers into oligonucleotides, as well as the formation of the first lipid bilayers.

Molecular Assemblies of Metal Complexes via Base-Pairing of Nucleic Acids in the Crystalline State

2017 ◽  
Vol 23 (30) ◽  
pp. 7232-7237 ◽  
Author(s):  
Manabu Nakaya ◽  
Ryo Ohtani ◽  
Kunihisa Sugimoto ◽  
Masaaki Nakamura ◽  
Leonard F. Lindoy ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Metal Complexes ◽  
Crystalline State ◽  
Base Pairing ◽  
Molecular Assemblies

ChemInform Abstract: Why Pentose- and Not Hexose-Nucleic Acids. Part 3. Oligo(2′,3′-dideoxy- β-D-glucopyranosyl)nucleotides. (“Homo-DNA”): Base-Pairing Properties.

ChemInform ◽  
2010 ◽  
Vol 24 (25) ◽  
pp. no-no
Author(s):  
J. HUNZIKER ◽  
H.-J. ROTH ◽  
M. BOEHRINGER ◽  
A. GIGER ◽  
U. DIEDERICHSEN ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Base Pairing ◽  
Dna Base

scholarly journals The study of complexation between dicationic surfactants and the DNA duplex using structural and spectroscopic methods

RSC Advances ◽  
2017 ◽  
Vol 7 (42) ◽  
pp. 26006-26018 ◽  
Author(s):  
W. Andrzejewska ◽  
M. Wilkowska ◽  
M. Chrabąszczewska ◽  
M. Kozak
Keyword(s):  
Nucleic Acids ◽  
Plasmid Dna ◽  
Living Cells ◽  
Spectroscopic Methods ◽  
Dna Duplex ◽  
Dna Oligomers ◽  
Different Types ◽  
Dicationic Surfactants ◽  
Viral Transfection

Dicationic (also known as gemini or dimeric) bis-alkylimidazolium surfactants belong to a group of non-viral transfection systems proposed for the successful introduction of different types of nucleic acids (i.e., siRNA, DNA oligomers, and plasmid DNA) into living cells.

Magnesium effect on premelting transitions in nucleic acids: DNA duplex and RNA hairpin models

2011 ◽  
Vol 993 (1-3) ◽  
pp. 324-327 ◽  
Author(s):  
Pavla Ottová ◽  
Shirly Josefina Espinoza-Herrera ◽  
Josef Štěpánek
Keyword(s):  
Nucleic Acids ◽  
Dna Duplex ◽  
Rna Hairpin
Sign in / Sign up

Export Citation Format

Share Document