A Simple Glycolipid Mimic of the Phosphatidylinositol Mannoside Core from Mycobacterium tuberculosis Inhibits Macrophage Cytokine Production

ChemBioChem ◽  
2018 ◽  
Vol 19 (14) ◽  
pp. 1476-1481 ◽  
Author(s):  
Tamim Mosaiab ◽  
Sandra Boiteux ◽  
Abu Hasanat Md Zulfiker ◽  
Ming Q. Wei ◽  
Milton J. Kiefel ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Cytokine Production ◽  
Macrophage Cytokine

scholarly journals The Facultative Intracellular PathogenCandida glabrataSubverts Macrophage Cytokine Production and Phagolysosome Maturation

2011 ◽  
Vol 187 (6) ◽  
pp. 3072-3086 ◽  
Author(s):  
Katja Seider ◽  
Sascha Brunke ◽  
Lydia Schild ◽  
Nadja Jablonowski ◽  
Duncan Wilson ◽  
...  
Keyword(s):  
Cytokine Production ◽  
Macrophage Cytokine

scholarly journals The Pattern of Cytokine Production In Vitro Induced by Ancient and Modern Beijing Mycobacterium tuberculosis Strains

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e94296 ◽  
Author(s):  
Yih-Yuan Chen ◽  
Jia-Ru Chang ◽  
Wei-Feng Huang ◽  
Shu-Ching Hsu ◽  
Shu-Chen Kuo ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Cytokine Production

Rifampin resistance mutations in the rpoB gene of Enterococcus faecalis impact host macrophage cytokine production

Cytokine ◽  
2022 ◽  
Vol 151 ◽  
pp. 155788
Author(s):  
Darya V. Urusova ◽  
Joseph A. Merriman ◽  
Ananya Gupta ◽  
Liang Chen ◽  
Barun Mathema ◽  
...  
Keyword(s):  
Enterococcus Faecalis ◽  
Cytokine Production ◽  
Rpob Gene ◽  
Resistance Mutations ◽  
Host Macrophage ◽  
Rifampin Resistance ◽  
Macrophage Cytokine

Evaluation of Murine Macrophage Cytokine Production After In Vivo Morphine Treatment

2014 ◽  
pp. 253-261 ◽  
Author(s):  
Silvia Franchi ◽  
Mara Castelli ◽  
Sarah Moretti ◽  
Alberto Panerai ◽  
Paola Sacerdote
Keyword(s):  
Cytokine Production ◽  
Murine Macrophage ◽  
Morphine Treatment ◽  
Macrophage Cytokine

scholarly journals Cyclosporin A Decreases Human Macrophage Interleukin-6 Synthesis at Post-Transcriptional Level

1999 ◽  
Vol 8 (4-5) ◽  
pp. 253-259 ◽  
Author(s):  
Juan E. Losa García ◽  
Ana M. Rodríguez López ◽  
María Rosa Martín De Cabo ◽  
Fernando Mateos Rodríguez ◽  
Jesús Pérez Losada ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Interleukin 6 ◽  
Cytokine Production ◽  
Regulatory Protein ◽  
Inhibition Mechanism ◽  
Transcriptional Level ◽  
Mrna Levels ◽  
Cytokine Inhibition ◽  
Cytokine Synthesis ◽  
Macrophage Cytokine

In addition to its well-established effect on T cells, cyclosporin A (CsA) also inhibits inflammatory cytokine production by macrophages. However, little is known about the mechanism of action of CsA on macrophage cytokine production. We measured the effect of CsA on basal and phorbol-myristate-acetate (PMA)-stimulated production of interleukin-6 using the human monocyte cell line U937 differentiated with dimethylsulfoxide (DMSO). Interleukin-6 levels were measured in supernatant and cell lysates using specific enzyme-linked immunosorbent assays. We found that CsA decreases not only IL-6 release but also cytokine synthesis. The concentration of CsA used did not affect either cell viability or proliferation. Three possibilities may be advanced to explain the CsA-due decrease in IL-6 production by macrophages: (a) inhibition of the synthesis of an early common regulatory protein, (b) inhibition of cytokine gene transcription, or (c) modulation of post-transcriptional events. The first possibility was tested by measuring the effect of cycloheximide on the experimental system during the first 3 hours of culture. Although cycloheximide decreased total cytokine synthesis, the pattern of cytokine modulation by CsA persisted. These data suggest that CsA-mediated macrophage cytokine inhibition is not mediated by an early common regulatory protein. To further explore the inhibition mechanism, we measured IL-6 mRNA levels by Northern blot. IL-6 mRNA levels were unaffected by CsA both in resting and PMA-stimulated cells. We conclude that in human macrophages CsA diminishes IL-6 production at post-transcriptional level.

scholarly journals Oral recombinant human or mouse lactoferrin reduces Mycobacterium tuberculosis TDM induced granulomatous lung pathology

2017 ◽  
Vol 95 (1) ◽  
pp. 148-154 ◽  
Author(s):  
Shen-An Hwang ◽  
Marian L. Kruzel ◽  
Jeffrey K. Actor
Keyword(s):  
Cell Wall ◽  
Mycobacterium Tuberculosis ◽  
Mouse Models ◽  
Lung Tissue ◽  
Cytokine Production ◽  
Lung Pathology ◽  
Leukocyte Populations ◽  
Human And Mouse

Trehalose 6′6-dimycolate (TDM) is the most abundant glycolipid on the cell wall of Mycobacterium tuberculosis (MTB). TDM is capable of inducing granulomatous pathology in mouse models that resembles those induced by MTB infection. Using the acute TDM model, this work investigates the effect of recombinant human and mouse lactoferrin to reduce granulomatous pathology. C57BL/6 mice were injected intravenously with TDM at a dose of 25 μg·mouse−1. At day 4 and 6, recombinant human or mouse lactoferrin (1 mg·(100 μL)−1·mouse−1) were delivered by gavage. At day 7 after TDM injection, mice were evaluated for lung pathology, cytokine production, and leukocyte populations. Mice given human or mouse lactoferrin had reduced production of IL-12p40 in their lungs. Mouse lactoferrin increased IL-6 and KC (CXCL1) in lung tissue. Increased numbers of macrophages were observed in TDM-injected mice given human or mouse lactoferrin. Granulomatous pathology, composed of mainly migrated leukocytes, was visually reduced in mice that received human or mouse lactoferrin. Quantitation of granulomatous pathology demonstrated a significant decrease in mice given human or mouse lactoferrin compared with TDM control mice. This report is the first to directly compare the immune modulatory effects of both heterologous recombinant human and homologous mouse lactoferrin on the development of TDM-induced granulomas.

scholarly journals The Effect of Hyperglycaemia on In Vitro Cytokine Production and Macrophage Infection with Mycobacterium tuberculosis

PLoS ONE ◽  
2015 ◽  
Vol 10 (2) ◽  
pp. e0117941 ◽  
Author(s):  
Ekta Lachmandas ◽  
Frank Vrieling ◽  
Louis G. Wilson ◽  
Simone A. Joosten ◽  
Mihai G. Netea ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Cytokine Production ◽  
Macrophage Infection
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