Biocatalytic Asymmetric Phosphorylation Catalyzed by Recombinant Glycerate-2-Kinase

ChemBioChem ◽  
2017 ◽  
Vol 18 (15) ◽  
pp. 1518-1522 ◽  
Author(s):  
Norman Hardt ◽  
Birhanu M. Kinfu ◽  
Jennifer Chow ◽  
Bernhard Schoenenberger ◽  
Wolfgang R. Streit ◽  
...  
Keyword(s):  
Asymmetric Phosphorylation

Nonenzymatic peptide-based catalytic asymmetric phosphorylation of inositol derivatives

2003 ◽  
pp. 1781 ◽  
Author(s):  
Bianca R. Sculimbrene ◽  
Adam J. Morgan ◽  
Scott J. Miller
Keyword(s):  
Catalytic Asymmetric ◽  
Asymmetric Phosphorylation

scholarly journals Zic2 abrogates an alternative Wnt signaling pathway to convert axon attraction into repulsion

2019 ◽  
Author(s):  
Cruz Morenilla-Palao ◽  
Maria Teresa López-Cascales ◽  
José P. López-Atalaya ◽  
Diana Baeza ◽  
Luis Calvo-Diaz ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Wnt Pathway ◽  
Alternative Pathway ◽  
Wnt Signaling Pathway ◽  
Optic Chiasm ◽  
Small Subset ◽  
Axon Pathfinding ◽  
Wnt Ligands ◽  
Wnt Pathways ◽  
Asymmetric Phosphorylation

ABSTRACTWnt signaling is involved in axon pathfinding during brain wiring but it is unknown how Wnt ligands promote attraction or repulsion. In addition, the participation of the canonical (βcatenin-dependent transcription) versus non-canonical (βcatenin-independent) Wnt pathways in this process remains controversial. Here we show that Wnt5a is expressed at the optic chiasm midline and promotes axon crossing by triggering an alternative Wnt pathway that depends on polarized accumulation of βcatenin at the axon terminal but does not activate the canonical pathway. Remarkably, this alternative pathway is silenced by the transcription factor Zic2 in the small subset of ipsilaterally projecting neurons. Zic2 directly regulates genes related to Wnt and Eph signaling that lead to global accumulation of βcatenin but triggers its asymmetric phosphorylation to facilitate the steering of the growth cone. This alternative Wnt pathway found in contralateral axons and its Zic2-mediated abrogation in ipsilateral neurons is likely operating in many other contexts requiring a two-way response to Wnt ligands.

Biocatalytic asymmetric phosphorylation of mevalonate

RSC Advances ◽  
2014 ◽  
Vol 4 (25) ◽  
pp. 12989 ◽  
Author(s):  
R. Matsumi ◽  
C. Hellriegel ◽  
B. Schoenenberger ◽  
T. Milesi ◽  
J. van der Oost ◽  
...  
Keyword(s):  
Asymmetric Phosphorylation
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