Fluorescence Probe for Detecting CCG Trinucleotide Repeat DNA Expansion and Slip-Out

ChemBioChem ◽  
2016 ◽  
Vol 17 (18) ◽  
pp. 1685-1688 ◽  
Author(s):  
Tomonori Shibata ◽  
Kazuhiko Nakatani
Keyword(s):  
Trinucleotide Repeat ◽  
Fluorescence Probe ◽  
Repeat Dna

Sequence-Dependent Effects of Monovalent Cations on the Structural Dynamics of Trinucleotide-Repeat DNA Hairpins

2018 ◽  
Vol 122 (50) ◽  
pp. 11841-11851 ◽  
Author(s):  
Marisa L. Mitchell ◽  
Michael P. Leveille ◽  
Roman S. Solecki ◽  
Thao Tran ◽  
Brian Cannon
Keyword(s):  
Structural Dynamics ◽  
Trinucleotide Repeat ◽  
Monovalent Cations ◽  
Dna Hairpins ◽  
Sequence Dependent ◽  
Repeat Dna

scholarly journals Solution structure of a small-molecular ligand complexed with CAG trinucleotide repeat DNA

2005 ◽  
Vol 49 (1) ◽  
pp. 49-50 ◽  
Author(s):  
Kazuhiko Nakatani ◽  
Shinya Hagihara ◽  
Yuki Goto ◽  
Akio Kobori ◽  
Masaki Hagihara ◽  
...  
Keyword(s):  
Solution Structure ◽  
Trinucleotide Repeat ◽  
Repeat Dna ◽  
Molecular Ligand

scholarly journals Trinucleotide Repeat DNA Alters Structure To Minimize the Thermodynamic Impact of 8-Oxo-7,8-dihydroguanine

Biochemistry ◽  
2011 ◽  
Vol 51 (1) ◽  
pp. 52-62 ◽  
Author(s):  
Catherine B. Volle ◽  
Daniel A. Jarem ◽  
Sarah Delaney
Keyword(s):  
Trinucleotide Repeat ◽  
Repeat Dna

A Three-Dimensional Tetraphenylethylene-Based Fluorescence Covalent Organic Framework for Molecular Recognition

2020 ◽  
Author(s):  
Junxia Ren ◽  
Yaozu Liu ◽  
Xin Zhu ◽  
Yangyang Pan ◽  
Yujie Wang ◽  
...  
Keyword(s):  
Molecular Recognition ◽  
Fluorescence Probe ◽  
Three Dimensional ◽  
Hazardous Substances ◽  
Covalent Organic Framework ◽  
Highly Sensitive ◽  
Volatile Organic ◽  
Polycyclic Aromatic ◽  
Better Than ◽  
Organic Framework

<p><a></a><a></a><a></a><a></a><a></a><a></a><a></a><a>The development of highly-sensitive recognition of </a><a></a><a></a><a></a><a></a><a>hazardous </a>chemicals, such as volatile organic compounds (VOCs) and polycyclic aromatic hydrocarbons (PAHs), is of significant importance because of their widespread social concerns related to environment and human health. Here, we report a three-dimensional (3D) covalent organic framework (COF, termed JUC-555) bearing tetraphenylethylene (TPE) side chains as an aggregation-induced emission (AIE) fluorescence probe for sensitive molecular recognition.<a></a><a> </a>Due to the rotational restriction of TPE rotors in highly interpenetrated framework after inclusion of dimethylformamide (DMF), JUC-555 shows impressive AIE-based strong fluorescence. Meanwhile, owing to the large pore size (11.4 Å) and suitable intermolecular distance of aligned TPE (7.2 Å) in JUC-555, the obtained material demonstrates an excellent performance in the molecular recognition of hazardous chemicals, e.g., nitroaromatic explosives, PAHs, and even thiophene compounds, via a fluorescent quenching mechanism. The quenching constant (<i>K</i><sub>SV</sub>) is two orders of magnitude better than those of other fluorescence-based porous materials reported to date. This research thus opens 3D functionalized COFs as a promising identification tool for environmentally hazardous substances.</p>

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