The Casein Kinase 2-Dependent Phosphorylation of NS5A Domain 3 from Hepatitis C Virus Followed by Time-Resolved NMR Spectroscopy

ChemBioChem ◽  
2016 ◽  
Vol 17 (4) ◽  
pp. 328-333 ◽  
Author(s):  
Erica Secci ◽  
Enrico Luchinat ◽  
Lucia Banci
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Nmr Spectroscopy ◽  
Casein Kinase ◽  
Casein Kinase 2 ◽  
Time Resolved ◽  
Domain 3

scholarly journals Casein Kinase II Inhibitor Enhances Production of Infectious Genotype 1a Hepatitis C Virus (H77S)

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e113938 ◽  
Author(s):  
Seungtaek Kim ◽  
Bora Jin ◽  
Sung Hoon Choi ◽  
Kwang-Hyub Han ◽  
Sang Hoon Ahn
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Casein Kinase Ii ◽  
Casein Kinase ◽  
Genotype 1A

P215 CASEIN KINASE I a PHOSPHORYLATES A KEY SITE IN NON-STRUCTURAL PROTEIN 5A RESPONSIBLE FOR HEPATITIS C VIRUS REPLICATION

2014 ◽  
Vol 60 (1) ◽  
pp. S137
Author(s):  
W.M. Chong ◽  
W.T. Kao ◽  
S.C. Hsu ◽  
J.S. Shao ◽  
Y.H. Chen ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Replication ◽  
Casein Kinase ◽  
Structural Protein ◽  
Casein Kinase I

scholarly journals Eu3+ /Sm3+ dual-label time-resolved fluoroimmunoassay for measurement of hepatitis C virus antibodies

2018 ◽  
Vol 33 (2) ◽  
pp. e22659 ◽  
Author(s):  
Xue Yang ◽  
Yan Ye ◽  
Tingting Wang ◽  
Mei Li ◽  
Lei Yu ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Time Resolved ◽  
Dual Label ◽  
Label Time

scholarly journals Soluble T-Cell Immunoglobulin Mucin Domain-3 Is Associated With Hepatitis C Virus Coinfection and Low-Grade Inflammation During Chronic Human Immunodeficiency Virus Infection

2020 ◽  
Vol 7 (2) ◽  
Author(s):  
Hedda Hoel ◽  
Thor Ueland ◽  
Malene Hove-Skovsgaard ◽  
Hans Jakob Hartling ◽  
Marco Gelpi ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Cell ◽  
Virus Infection ◽  
Cross Sectional ◽  
Art Initiation ◽  
Immune Exhaustion ◽  
Immunodeficiency Virus ◽  
Domain 3

Abstract Background In well treated human immunodeficiency virus infection (HIV), there is a residual immune activation and immune exhaustion that may contribute to increased risk of comorbidities. T-cell immunoglobulin mucin domain-3 (Tim-3) is an inhibitory molecule involved in HIV-associated T-cell dysfunction. The Tim-3 can be cleaved to soluble Tim-3 (sTim-3) that may serve as a soluble marker of immune exhaustion. Methods We measured sTim-3 with enzyme-linked immunosorbent assay DuoSets in a cross-sectional cohort of 1010 people with HIV (PWH) on antiretroviral therapy (ART), and 76 controls from the Copenhagen Co-Morbidity in HIV Infection (COCOMO) study, and in a longitudinal cohort of 60 PWH before and during ART. Results In the cross-sectional cohort, levels of sTim-3 were elevated in PWH on ART compared with controls, especially in hepatitis C virus (HCV)-coinfected individuals, and were associated with HCV viremia and inflammation. In the longitudinal cohort, pretreatment sTim-3 correlated with HIV viral load and decreased after ART initiation. Pretreatment sTim-3 correlated inversely with CD4 counts, but it did not predict immunological response in multivariable analyses. Conclusions Levels of sTim-3 decreased after ART initiation. In a cross-sectional cohort, levels of sTIM-3 were higher in PWH than in controls and were independently associated with HCV coinfection and high-sensitivity C-reactive protein, representing a potential link between immune exhaustion, inflammation, and risk of comorbidities.

Sign in / Sign up

Export Citation Format

Share Document