Sequence-Dependent Structural Dynamics of Primate Adenosine-to-Inosine Editing Substrates

ChemBioChem ◽  
2012 ◽  
Vol 13 (18) ◽  
pp. 2714-2721 ◽  
Author(s):  
Michael Samir Dahabieh ◽  
Dhrubajyoti Samanta ◽  
Jean-Claude Brodovitch ◽  
Christian Frech ◽  
Melanie A. O'Neill ◽  
...  
Keyword(s):  
Structural Dynamics ◽  
Sequence Dependent

Sequence-Dependent Effects of Monovalent Cations on the Structural Dynamics of Trinucleotide-Repeat DNA Hairpins

2018 ◽  
Vol 122 (50) ◽  
pp. 11841-11851 ◽  
Author(s):  
Marisa L. Mitchell ◽  
Michael P. Leveille ◽  
Roman S. Solecki ◽  
Thao Tran ◽  
Brian Cannon
Keyword(s):  
Structural Dynamics ◽  
Trinucleotide Repeat ◽  
Monovalent Cations ◽  
Dna Hairpins ◽  
Sequence Dependent ◽  
Repeat Dna

Structural dynamics of P-type ATPase ion pumps

2019 ◽  
Vol 47 (5) ◽  
pp. 1247-1257 ◽  
Author(s):  
Mateusz Dyla ◽  
Sara Basse Hansen ◽  
Poul Nissen ◽  
Magnus Kjaergaard
Keyword(s):  
Structural Dynamics ◽  
Single Molecule ◽  
New Technologies ◽  
Atp Hydrolysis ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Time Resolved ◽  
Dynamics Simulations ◽  
Types Of Information ◽  
P Type

Abstract P-type ATPases transport ions across biological membranes against concentration gradients and are essential for all cells. They use the energy from ATP hydrolysis to propel large intramolecular movements, which drive vectorial transport of ions. Tight coordination of the motions of the pump is required to couple the two spatially distant processes of ion binding and ATP hydrolysis. Here, we review our current understanding of the structural dynamics of P-type ATPases, focusing primarily on Ca2+ pumps. We integrate different types of information that report on structural dynamics, primarily time-resolved fluorescence experiments including single-molecule Förster resonance energy transfer and molecular dynamics simulations, and interpret them in the framework provided by the numerous crystal structures of sarco/endoplasmic reticulum Ca2+-ATPase. We discuss the challenges in characterizing the dynamics of membrane pumps, and the likely impact of new technologies on the field.

Structural dynamics of free molecules and condensed matter

2018 ◽  
Vol 190 (02) ◽  
pp. 113-136
Author(s):  
Sergei A. Aseyev ◽  
A.S. Akhmanov ◽  
G.V. Girichev ◽  
Anatoly A. Ischenko ◽  
Igor V. Kochikov ◽  
...  
Keyword(s):  
Structural Dynamics ◽  
Condensed Matter ◽  
Free Molecules
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