Cover Picture: Small Molecule Modulates Hairpin Structures in CAG Trinucleotide Repeats (ChemBioChem 11/2011)

ChemBioChem ◽  
2011 ◽  
Vol 12 (11) ◽  
pp. 1609-1609
Author(s):  
Masaki Hagihara ◽  
Hanping He ◽  
Kazuhiko Nakatani
Keyword(s):  
Small Molecule ◽  
Trinucleotide Repeats ◽  
Cag Trinucleotide Repeats ◽  
Hairpin Structures

Small Molecule Modulates Hairpin Structures in CAG Trinucleotide Repeats

ChemBioChem ◽  
2011 ◽  
Vol 12 (11) ◽  
pp. 1686-1689 ◽  
Author(s):  
Masaki Hagihara ◽  
Hanping He ◽  
Kazuhiko Nakatani
Keyword(s):  
Small Molecule ◽  
Trinucleotide Repeats ◽  
Cag Trinucleotide Repeats ◽  
Hairpin Structures

A small molecule regulates hairpin structures in d(CGG) trinucleotide repeats

2012 ◽  
Vol 22 (5) ◽  
pp. 2000-2003 ◽  
Author(s):  
Masaki Hagihara ◽  
Hanping He ◽  
Maki Kimura ◽  
Kazuhiko Nakatani
Keyword(s):  
Small Molecule ◽  
Trinucleotide Repeats ◽  
Hairpin Structures

scholarly journals Huntington's Disease: An Immune Perspective

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Annapurna Nayak ◽  
Rafia Ansar ◽  
Sunil K. Verma ◽  
Domenico Marco Bonifati ◽  
Uday Kishore
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Neurodegenerative Disorder ◽  
Typical Feature ◽  
Trinucleotide Repeats ◽  
Mutant Huntingtin Protein ◽  
Unexplored Area ◽  
Cag Trinucleotide Repeats ◽  
The Brain ◽  
Abnormal Expansion

Huntington's disease (HD) is a progressive neurodegenerative disorder that is caused by abnormal expansion of CAG trinucleotide repeats. Neuroinflammation is a typical feature of most neurodegenerative diseases that leads to an array of pathological changes within the affected areas in the brain. The neurodegeneration in HD is also caused by aberrant immune response in the presence of aggregated mutant huntingtin protein. The effects of immune activation in HD nervous system are a relatively unexplored area of research. This paper summarises immunological features associated with development and progression of HD.

Glutamine repeats: structural hypotheses and neurodegeneration

2002 ◽  
Vol 30 (4) ◽  
pp. 548-551 ◽  
Author(s):  
L. Masino ◽  
A. Pastore
Keyword(s):  
Protein Misfolding ◽  
Trinucleotide Repeats ◽  
Intranuclear Inclusions ◽  
The Past ◽  
Cag Trinucleotide Repeats ◽  
Protein Misfolding And Aggregation ◽  
Polyglutamine Protein ◽  
Molecular Bases ◽  
Protein Models

A growing number of neurodegenerative diseases are caused by expansion of CAG trinucleotide repeats coding for polyglutamine. The presence of intranuclear inclusions in the affected neuronal cells has suggested a mechanism for pathogenesis based on protein misfolding and aggregation. Detailed understanding of these phenomena is therefore crucial in order to rationalize different phases of the diseases. In the past decade, a few studies have focused on the structural properties of polyglutamine and on the molecular bases of the aggregation process. Most of these studies have been performed on polyglutamine peptides and protein models. Only one report is currently available on the characterization of a full-length polyglutamine protein. The structural hypotheses resulting from these studies are reviewed here.

cDNAs with long CAG trinucleotide repeats from human brain

1997 ◽  
Vol 100 (1) ◽  
pp. 114 ◽  
Author(s):  
Russell L. Margolis ◽  
Meena R. Abraham ◽  
Shawn B. Gatchell ◽  
Shi-Hua Li ◽  
Arif S. Kidwai ◽  
...  
Keyword(s):  
Human Brain ◽  
Trinucleotide Repeats ◽  
Cag Trinucleotide Repeats

Association study between CAG trinucleotide repeats in the PCQAP gene (PC2 glutamine/Q-rich-associated protein) and schizophrenia

2002 ◽  
Vol 116B (1) ◽  
pp. 32-35 ◽  
Author(s):  
Alessandro De Luca ◽  
Emanuela Conti ◽  
Nicoletta Grifone ◽  
Francesca Amati ◽  
Gianfranco Spalletta ◽  
...  
Keyword(s):  
Association Study ◽  
Trinucleotide Repeats ◽  
Cag Trinucleotide Repeats

scholarly journals Trinucleotide repeats that expand in human disease form hairpin structures in vitro

Cell ◽  
1995 ◽  
Vol 81 (4) ◽  
pp. 533-540 ◽  
Author(s):  
A. Marquis Gacy ◽  
Geoffrey Goellner ◽  
Nenad Juranić ◽  
Slobodan Macura ◽  
Cynthia T. McMurray
Keyword(s):  
Human Disease ◽  
Trinucleotide Repeats ◽  
Hairpin Structures
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