Complex Oxidation Chemistry in the Biosynthetic Pathways to Vancomycin/Teicoplanin Antibiotics

ChemBioChem ◽  
2009 ◽  
Vol 10 (11) ◽  
pp. 1757-1764 ◽  
Author(s):  
Paul F. Widboom ◽  
Steven D. Bruner
Keyword(s):  
Biosynthetic Pathways ◽  
Oxidation Chemistry ◽  
Complex Oxidation

A Transient VIII–Alkylidene Complex: Oxidation Chemistry Including the Activation of N2 to Afford a Highly Porous Honeycomb-Like Framework

2008 ◽  
Vol 47 (20) ◽  
pp. 3769-3772 ◽  
Author(s):  
Uriah J. Kilgore ◽  
Caitlin A. Sengelaub ◽  
Maren Pink ◽  
Alison R. Fout ◽  
Daniel J. Mindiola
Keyword(s):  
Oxidation Chemistry ◽  
Highly Porous ◽  
Complex Oxidation

A Transient VIII–Alkylidene Complex: Oxidation Chemistry Including the Activation of N2 to Afford a Highly Porous Honeycomb-Like Framework

2008 ◽  
Vol 120 (20) ◽  
pp. 3829-3832 ◽  
Author(s):  
Uriah J. Kilgore ◽  
Caitlin A. Sengelaub ◽  
Maren Pink ◽  
Alison R. Fout ◽  
Daniel J. Mindiola
Keyword(s):  
Oxidation Chemistry ◽  
Highly Porous ◽  
Complex Oxidation

Discovery of fatty acid synthase inhibitors and their biosynthetic pathways by a novel target-directed genome mining strategy

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
J Li ◽  
X Tang ◽  
JJ Zhang ◽  
EC O'Neill ◽  
SM Mantovani ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthase ◽  
Genome Mining ◽  
Biosynthetic Pathways ◽  
Novel Target

Oxidase Catalysis via an Aerobically Generated Dess-Martin Periodinane Analogue

2018 ◽  
Author(s):  
Asim Maity ◽  
Sung-Min Hyun ◽  
Alan Wortman ◽  
David Powers
Keyword(s):  
Chemical Synthesis ◽  
Aerobic Oxidation ◽  
Substrate Oxidation ◽  
Oxidation Catalysis ◽  
Hypervalent Iodine ◽  
Oxidation Reactions ◽  
Broad Array ◽  
Oxidation Chemistry ◽  
Reactive Oxidants

<p>Hypervalent iodine(V) reagents, such as Dess-Martin periodinane (DMP) and 2-iodoxybenzoic acid (IBX), are broadly useful oxidants in chemical synthesis. Development of strategies to access these reagents from O2 would immediately enable use of O2 as a terminal oxidant in a broad array of substrate oxidation reactions. Recently we disclosed the aerobic synthesis of I(III) reagents by intercepting reactive oxidants generated during aldehyde autoxidation. Here, we couple aerobic oxidation of iodobenzenes with disproportionation of the initially generated I(III) compounds to generate I(V) reagents. The aerobically generated I(V) reagents exhibit substrate oxidation chemistry analogous to that of DMP. Further, the developed aerobic generation of I(V) has enabled the first application of I(V) intermediates in aerobic oxidation catalysis.</p>

An Overview on Steroids and Microwave Energy in Multi-Component Reactions towards the Synthesis of Novel Hybrid Molecules

2020 ◽  
Vol 17 (8) ◽  
pp. 594-609
Author(s):  
Preetismita Borah ◽  
Vhatkar Dattatraya Shivling ◽  
Bimal Krishna Banik ◽  
Biswa Mohan Sahoo
Keyword(s):  
Energy Consumption ◽  
Multicomponent Reactions ◽  
Biological Activities ◽  
Vital Role ◽  
Microwave Energy ◽  
Biosynthetic Pathways ◽  
Chemical Transformations ◽  
Carbon Carbon Bond ◽  
Hybrid Molecules ◽  
Time Required

In recent years, hybrid systems are gaining considerable attention owing to their various biological applications in drug development. Generally, hybrid molecules are constructed from different molecular entities to generate a new functional molecule with improved biological activities. There already exist a large number of naturally occurring hybrid molecules based on both non-steroid and steroid frameworks synthesized by nature through mixed biosynthetic pathways such as, a) integration of the different biosynthetic pathways or b) Carbon- Carbon bond formation between different components derived through different biosynthetic pathways. Multicomponent reactions are a great way to generate efficient libraries of hybrid compounds with high diversity. Throughout the scientific history, the most common factors developing technologies are less energy consumption and avoiding the use of hazardous reagents. In this case, microwave energy plays a vital role in chemical transformations since it involves two very essential criteria of synthesis, minimizing energy consumption required for heating and time required for the reaction. This review summarizes the use of microwave energy in the synthesis of steroidal and non-steroidal hybrid molecules and the use of multicomponent reactions.

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