scholarly journals Molecular Assembly of an Aptamer-Drug Conjugate for Targeted Drug Delivery to Tumor Cells

ChemBioChem ◽  
2009 ◽  
Vol 10 (5) ◽  
pp. 862-868 ◽  
Author(s):  
Yu-Fen Huang ◽  
Dihua Shangguan ◽  
Haipeng Liu ◽  
Joseph A. Phillips ◽  
Xiaoling Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Targeted Drug Delivery ◽  
Molecular Assembly ◽  
Drug Conjugate ◽  
Targeted Drug

Targeted killing of metastatic cells using a platelet-inspired drug delivery system

RSC Advances ◽  
2015 ◽  
Vol 5 (57) ◽  
pp. 46218-46228 ◽  
Author(s):  
Victor Pan ◽  
Preethi N. Siva ◽  
Christa L. Modery-Pawlowski ◽  
Ujjal Didar Singh Sekhon ◽  
Anirban Sen Gupta
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Drug Delivery System ◽  
Targeted Drug Delivery ◽  
Metastatic Tumor ◽  
Targeted Killing ◽  
Metastatic Cells ◽  
System P ◽  
Delivery Vehicles ◽  
Targeted Drug

Pro-metastatic tumor cells in circulation interact with active platelets that mediate various mechanisms of hematologic metastasis. Elucidating and utilizing these interactions on delivery vehicles can provide unique ways of metastasis-targeted drug delivery.

Biotinylated carboxymethyl chitosan/CaCO3 hybrid nanoparticles for targeted drug delivery to overcome tumor drug resistance

RSC Advances ◽  
2016 ◽  
Vol 6 (73) ◽  
pp. 69083-69093 ◽  
Author(s):  
Jin-Long Wu ◽  
Xiao-Yan He ◽  
Pei-Yuan Jiang ◽  
Meng-Qing Gong ◽  
Ren-Xi Zhuo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Tumor Cells ◽  
Targeted Drug Delivery ◽  
Carboxymethyl Chitosan ◽  
Hybrid Nanoparticles ◽  
Cancer Drug ◽  
Tumor Drug Resistance ◽  
Anti Cancer ◽  
Targeted Drug

A tumor targeted nano-sized self-assembled drug delivery system could efficiently co-deliver an anti-cancer drug and a drug resistance inhibitor to tumor cells and achieve an improved therapeutic efficiency through inhibition of P-gp function.

Targeted drug delivery system for doxorubicin based on a specific peptide and phospholipid nanoparticles

2020 ◽  
Vol 66 (6) ◽  
pp. 464-468
Author(s):  
L.V. Kostryukova ◽  
Y.A. Tereshkina ◽  
E.I. Korotkevich ◽  
V.N. Prozorovsky ◽  
T.I. Torkhovskaya ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Breast Adenocarcinoma ◽  
Control Line ◽  
Phospholipid Nanoparticles ◽  
Significant Difference ◽  
Targeted Drug ◽  
Cd13 Receptor

Doxorubicin is one of the widely known and frequently used chemotherapy drugs for the treatment of various types of cancer, the use of which is difficult due to its high cardiotoxicity. Targeted drug delivery systems are being developed to reduce side effects. One of the promising components as vector molecules (ligands) are NGR-containing peptides that are affinity for the CD13 receptor, which is expressed on the surface of many tumor cells and tumor blood vessels. Previously, a method was developed for preparing a composition of doxorubicin embedded in phospholipid nanoparticles with a targeted fragment in the form of an ultrafine emulsion. The resulting composition was characterized by a small particle size (less than 40 nm) and a high degree of incorporation of doxorubicin (about 93%) into transport nanoparticles. When assessing the penetrating ability and the degree of binding to the surface of fibrosarcoma cells (HT-1080), it was shown that when the composition with the targeted fragment was added to the cells, the level of doxorubicin was almost 2 times higher than that of the liposomal form of doxorubicin, i.e. the drug in the system with the targeted peptide penetrated the cell better. At the same time, on the control line of breast adenocarcinoma cells (MCF-7), which do not express the CD13 receptor on the surface, there was not significant difference in the level of doxorubicin in the cells. The data obtained allow us to draw preliminary conclusions about the prospects of targeted delivery of doxorubicin to tumor cells when using a peptide conjugate containing an NGR motif and the further need for its comprehensive study.

Folate-conjugated nanodiamond for tumor-targeted drug delivery

RSC Advances ◽  
2015 ◽  
Vol 5 (101) ◽  
pp. 82711-82716 ◽  
Author(s):  
Yu Dong ◽  
Ruixia Cao ◽  
Yingqi Li ◽  
Zhiqin Wang ◽  
Lin Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Targeted Drug Delivery ◽  
Normal Cells ◽  
Folate Receptors ◽  
Receptor Mediated Endocytosis ◽  
Targeted Drug

Relying on the role of folate and folate receptors, NPFD nanoparticles tend to selectively discriminate tumor cells from normal cells and enter the cells by clathrin-dependent and receptor-mediated endocytosis.

Chemically Edited Exosomes with Dual Ligand Purified by Microfluidic Device for Active Targeted Drug Delivery to Tumor Cells

2017 ◽  
Vol 9 (33) ◽  
pp. 27441-27452 ◽  
Author(s):  
Jie Wang ◽  
Wei Li ◽  
Leicheng Zhang ◽  
Lin Ban ◽  
Peng Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Microfluidic Device ◽  
Targeted Drug Delivery ◽  
Targeted Drug

A biodegradable and fluorescent nanovehicle with enhanced selective uptake by tumor cells

2015 ◽  
Vol 6 (36) ◽  
pp. 6529-6542 ◽  
Author(s):  
Jinxia An ◽  
Xiaomei Dai ◽  
Yu Zhao ◽  
Qianqian Guo ◽  
Zhongming Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Fluorescence Imaging ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Anticancer Effect ◽  
Targeted Drug ◽  
Ph Dependent ◽  
Targeted Drug Delivery System

The tumor-targeted drug delivery system, DOX@LA-pDAGEA/pPEGA-b-p(DMDEA-co-BADS), with reduction- and pH-dependent degradation and fluorescence imaging function displayed an enhanced anticancer effect.

Inorganic Nanovehicle for Potential Targeted Drug Delivery to Tumor Cells, Tumor Optical Imaging

2015 ◽  
Vol 7 (9) ◽  
pp. 5089-5096 ◽  
Author(s):  
Shiyong Yu ◽  
Xuechuan Gao ◽  
Huricha Baigude ◽  
Xiao Hai ◽  
Renfei Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optical Imaging ◽  
Tumor Cells ◽  
Targeted Drug Delivery ◽  
Targeted Drug
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