Discovery of Mycobacterium Tuberculosis Protein Tyrosine Phosphatase A (MptpA) Inhibitors Based on Natural Products and a Fragment-Based Approach

ChemBioChem ◽  
2005 ◽  
Vol 6 (10) ◽  
pp. 1749-1753 ◽  
Author(s):  
Michael Manger ◽  
Michael Scheck ◽  
Heino Prinz ◽  
Jens Peter von Kries ◽  
Thomas Langer ◽  
...  
Keyword(s):  
Natural Products ◽  
Mycobacterium Tuberculosis ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine

scholarly journals Discovery of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B (PtpB) Inhibitors from Natural Products

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e77081 ◽  
Author(s):  
Alessandra Mascarello ◽  
Mattia Mori ◽  
Louise Domeneghini Chiaradia-Delatorre ◽  
Angela Camila Orbem Menegatti ◽  
Franco Delle Monache ◽  
...  
Keyword(s):  
Natural Products ◽  
Mycobacterium Tuberculosis ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine

scholarly journals PAIN-less identification and evaluation of small molecule inhibitors against protein tyrosine phosphatase 1B

MedChemComm ◽  
2017 ◽  
Vol 8 (6) ◽  
pp. 1220-1224 ◽  
Author(s):  
Hamid R. Nasiri ◽  
Philipp Mracek ◽  
Steffen K. Grimm ◽  
Janine Gastaldello ◽  
Adrian Kolodzik ◽  
...  
Keyword(s):  
Natural Products ◽  
Small Molecule ◽  
Protein Tyrosine Phosphatase ◽  
Small Molecule Inhibitors ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Set Up ◽  
Assay Interference

A miniaturized assay was set up to test a set of natural products against protein tyrosine phosphatase 1B (PTP1B). By using several read-out and counter assays, berberine and palmatine were identified as PAINS (pan-assay interference compounds) and α-TOS as a novel inhibitor of PTP1B.

ATP synthase, an essential enzyme in growth and multiplication is modulated by protein tyrosine phosphatase in Mycobacterium tuberculosis H37Ra

Biochimie ◽  
2019 ◽  
Vol 165 ◽  
pp. 156-160 ◽  
Author(s):  
Aditi Chatterjee ◽  
Sapna Pandey ◽  
Ekta Dhamija ◽  
Swati Jaiswal ◽  
Shivraj M. Yabaji ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Atp Synthase ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine ◽  
Essential Enzyme

Inhibitors of Protein Tyrosine Phosphatase 1B from Marine Natural Products

2017 ◽  
Vol 14 (7) ◽  
pp. e1600462 ◽  
Author(s):  
Yue Zhou ◽  
Weirui Zhang ◽  
Xiaoyu Liu ◽  
Haobing Yu ◽  
Xiaoling Lu ◽  
...  
Keyword(s):  
Natural Products ◽  
Protein Tyrosine Phosphatase ◽  
Marine Natural Products ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine
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