scholarly journals Cover Picture: Locked Nucleic Acids and Intercalating Nucleic Acids in the Design of Easily Denaturing Nucleic Acids: Thermal Stability Studies (ChemBioChem 12/2004)

ChemBioChem ◽  
2004 ◽  
Vol 5 (12) ◽  
pp. 1613-1613
Author(s):  
Vyacheslav V. Filichev ◽  
Ulf B. Christensen ◽  
Erik B. Pedersen ◽  
B. Ravindra Babu ◽  
Jesper Wengel
Keyword(s):  
Thermal Stability ◽  
Nucleic Acids ◽  
Stability Studies ◽  
Locked Nucleic Acids

Locked Nucleic Acids and Intercalating Nucleic Acids in the Design of Easily Denaturing Nucleic Acids: Thermal Stability Studies

ChemBioChem ◽  
2004 ◽  
Vol 5 (12) ◽  
pp. 1673-1679 ◽  
Author(s):  
Vyacheslav V. Filichev ◽  
Ulf B. Christensen ◽  
Erik B. Pedersen ◽  
B. Ravindra Babu ◽  
Jesper Wengel
Keyword(s):  
Thermal Stability ◽  
Nucleic Acids ◽  
Stability Studies ◽  
Locked Nucleic Acids

Synthesis of Twisted Intercalating Nucleic Acids Possessing Acridine Derivatives. Thermal Stability Studies

2006 ◽  
Vol 17 (4) ◽  
pp. 950-957 ◽  
Author(s):  
Imrich Géci ◽  
Vyacheslav V. Filichev ◽  
Erik B. Pedersen
Keyword(s):  
Thermal Stability ◽  
Nucleic Acids ◽  
Stability Studies ◽  
Acridine Derivatives

scholarly journals Kinetics of DNA Strand Displacement Systems with Locked Nucleic Acids

2017 ◽  
Vol 121 (12) ◽  
pp. 2594-2602 ◽  
Author(s):  
Xiaoping Olson ◽  
Shohei Kotani ◽  
Bernard Yurke ◽  
Elton Graugnard ◽  
William L. Hughes
Keyword(s):  
Nucleic Acids ◽  
Strand Displacement ◽  
Dna Strand Displacement ◽  
Locked Nucleic Acids ◽  
Dna Strand ◽  
Kinetics Of

Growth and thermal stability studies of layered GaTe single crystals in inert atmospheres

2021 ◽  
Vol 296 ◽  
pp. 121996
Author(s):  
Thi Hoa Vu ◽  
Anh Tuan Pham ◽  
Van Quang Nguyen ◽  
Anh Duc Nguyen ◽  
Thao Nhi Nguyen Tran ◽  
...  
Keyword(s):  
Thermal Stability ◽  
Single Crystals ◽  
Stability Studies

scholarly journals Silencing Antibiotic Resistance with Antisense Oligonucleotides

Biomedicines ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 416
Author(s):  
Saumya Jani ◽  
Maria Soledad Ramirez ◽  
Marcelo E. Tolmasky
Keyword(s):  
Antibiotic Resistance ◽  
Nucleic Acids ◽  
Antisense Oligonucleotides ◽  
Bacterial Infections ◽  
Genetic Disorders ◽  
Antibiotic Resistance Genes ◽  
Short Review ◽  
Rnase H ◽  
Biological Processes ◽  
Locked Nucleic Acids

Antisense technologies consist of the utilization of oligonucleotides or oligonucleotide analogs to interfere with undesirable biological processes, commonly through inhibition of expression of selected genes. This field holds a lot of promise for the treatment of a very diverse group of diseases including viral and bacterial infections, genetic disorders, and cancer. To date, drugs approved for utilization in clinics or in clinical trials target diseases other than bacterial infections. Although several groups and companies are working on different strategies, the application of antisense technologies to prokaryotes still lags with respect to those that target other human diseases. In those cases where the focus is on bacterial pathogens, a subset of the research is dedicated to produce antisense compounds that silence or reduce expression of antibiotic resistance genes. Therefore, these compounds will be adjuvants administered with the antibiotic to which they reduce resistance levels. A varied group of oligonucleotide analogs like phosphorothioate or phosphorodiamidate morpholino residues, as well as peptide nucleic acids, locked nucleic acids and bridge nucleic acids, the latter two in gapmer configuration, have been utilized to reduce resistance levels. The major mechanisms of inhibition include eliciting cleavage of the target mRNA by the host’s RNase H or RNase P, and steric hindrance. The different approaches targeting resistance to β-lactams include carbapenems, aminoglycosides, chloramphenicol, macrolides, and fluoroquinolones. The purpose of this short review is to summarize the attempts to develop antisense compounds that inhibit expression of resistance to antibiotics.

FISHing with locked nucleic acids (LNA): evaluation of different LNA/DNA mixmers

2003 ◽  
Vol 17 (4) ◽  
pp. 165-169 ◽  
Author(s):  
Asli N Silahtaroglu ◽  
Niels Tommerup ◽  
Henrik Vissing
Keyword(s):  
Nucleic Acids ◽  
Locked Nucleic Acids
Sign in / Sign up

Export Citation Format

Share Document