Forced Intercalation Probes (FIT Probes): Thiazole Orange as a Fluorescent Base in Peptide Nucleic Acids for Homogeneous Single-Nucleotide-Polymorphism Detection

ChemBioChem ◽  
2004 ◽  
Vol 6 (1) ◽  
pp. 69-77 ◽  
Author(s):  
Olaf Köhler ◽  
Dilip Venkatrao Jarikote ◽  
Oliver Seitz
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Nucleic Acids ◽  
Peptide Nucleic Acids ◽  
Thiazole Orange ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide Polymorphism Detection ◽  
Single Nucleotide ◽  
Polymorphism Detection

scholarly journals Facile functionalization of peptide nucleic acids (PNAs) for antisense and single nucleotide polymorphism detection

2017 ◽  
Vol 15 (32) ◽  
pp. 6710-6714 ◽  
Author(s):  
Digvijay Gahtory ◽  
Merita Murtola ◽  
Maarten M. J. Smulders ◽  
Tom Wennekes ◽  
Han Zuilhof ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Nucleic Acids ◽  
Peptide Nucleic Acids ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide Polymorphism Detection ◽  
Single Nucleotide ◽  
Polymorphism Detection ◽  
Detection Strategies

In this report, we show how a convenient on-resin copper-click functionalization of azido-functionalized peptide nucleic acids (PNAs) allows various PNA-based detection strategies.

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