The Discovery of Novel Protein Kinase Inhibitors by Using Fragment-Based High-Throughput X-ray Crystallography

ChemBioChem ◽  
2005 ◽  
Vol 6 (3) ◽  
pp. 506-512 ◽  
Author(s):  
Adrian Gill ◽  
Anne Cleasby ◽  
Harren Jhoti
Keyword(s):  
Protein Kinase ◽  
High Throughput ◽  
Kinase Inhibitors ◽  
Protein Kinase Inhibitors ◽  
X Ray ◽  
X Ray Crystallography ◽  
Novel Protein

scholarly journals Data set of competitive and allosteric protein kinase inhibitors confirmed by X-ray crystallography

Data in Brief ◽  
2021 ◽  
Vol 35 ◽  
pp. 106816
Author(s):  
Huabin Hu ◽  
Oliver Laufkötter ◽  
Filip Miljković ◽  
Jürgen Bajorath
Keyword(s):  
Protein Kinase ◽  
Kinase Inhibitors ◽  
Protein Kinase Inhibitors ◽  
Data Set ◽  
X Ray ◽  
X Ray Crystallography ◽  
Allosteric Protein

A robust and quantitative assay platform for multiplexed, high throughput screening of protein kinase inhibitors

2016 ◽  
Vol 52 (81) ◽  
pp. 12112-12115 ◽  
Author(s):  
Jieon Lee ◽  
Il-Soo Park ◽  
Ginam Park ◽  
Kyukwang Cho ◽  
Hee-Sung Park ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Protein Kinase ◽  
High Throughput ◽  
High Throughput Screening ◽  
Kinase Activity ◽  
Kinase Inhibitors ◽  
Protein Kinase Inhibitors ◽  
Protein Kinase Activity ◽  
Activity Assay ◽  
Kinase Activity Assay

We present a new platform for multiplexed protein kinase activity assay using TiO2decorated graphene oxide (GO), which is applicable to high throughput inhibitor screening.

9322 Novel protein kinase inhibitors in melanoma

2009 ◽  
Vol 7 (2) ◽  
pp. 583-584
Author(s):  
T. Mahgoub ◽  
M. Clynes ◽  
J. Crown ◽  
N. O'Donovan
Keyword(s):  
Protein Kinase ◽  
Kinase Inhibitors ◽  
Protein Kinase Inhibitors ◽  
Novel Protein

scholarly journals Novel Protein Kinase Inhibitors: SMART Drug Design Technology

BioTechniques ◽  
2003 ◽  
Vol 34 (6S) ◽  
pp. S2-S15 ◽  
Author(s):  
Tomi K. Sawyer ◽  
Regine S. Bohacek ◽  
Chester A. Metcalf III ◽  
William C. Shakespeare ◽  
Yihan Wang ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Drug Design ◽  
Kinase Inhibitors ◽  
Protein Kinase Inhibitors ◽  
Design Technology ◽  
Smart Drug ◽  
Novel Protein
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