Porphyrin Derivatives for Telomere Binding and Telomerase Inhibition

ChemBioChem ◽  
2004 ◽  
Vol 6 (1) ◽  
pp. 123-132 ◽  
Author(s):  
Isabelle M. Dixon ◽  
Frédéric Lopez ◽  
Jean-Pierre Estève ◽  
Agueda M. Tejera ◽  
María A. Blasco ◽  
...  
Keyword(s):  
Telomerase Inhibition ◽  
Porphyrin Derivatives

463: Telomerase Inhibition Prevents Androgen Independent Osseous Prostate Cancer Progression

2005 ◽  
Vol 173 (4S) ◽  
pp. 126-127
Author(s):  
Yingming Li ◽  
Melissa Thompson ◽  
Zhu Chen ◽  
Bahaa S. Malaeb ◽  
David Corey ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Prostate Cancer Progression ◽  
Telomerase Inhibition ◽  
Androgen Independent

A Brief Introduction to Porphyrin Compounds Used in Tumor Imaging and Therapies

2020 ◽  
Vol 20 ◽  
Author(s):  
Lili Pan ◽  
Yu Ma ◽  
Xiaoai Wu ◽  
Huawei Cai ◽  
Feng Qin ◽  
...  
Keyword(s):  
Tumor Imaging ◽  
Photoacoustic Imaging ◽  
Therapeutic Agents ◽  
Biochemical Properties ◽  
Therapeutic Effects ◽  
Future Prospects ◽  
Animal Tissues ◽  
Sonodynamic Therapy ◽  
Porphyrin Derivatives ◽  
Porphyrin Analogues

Abstract:: As a group of heterocyclic macrocycle organic natural compounds occurring universally in animal tissues and plants, porphyrins are composed of four modified pyrrole subunits. Porphyrin analogues/derivatives possess multiple biochemical properties because of their unique structures and have been extensively investigated in cancer treatment. Studies have shown that porphyrins and their derivatives have the ability to locate in tumor cells in a variety of human cancers, and these compounds not only exhibit potent therapeutic effects as photodynamic agents but also show promising properties in medicinal imaging, such as MRI, photoacoustic imaging, fluorescence imaging and PET/SPECT imaging. This paper reviews the recent reports of porphyrin derivatives as therapeutic agents used in tumor therapies, such as sonodynamic therapy, photodynamic therapy and radiotherapy, as well as imaging agents for multimodality tumor imaging. The limitations of porphyrin-based compounds in tumor treatments and future prospects are also summarized.

Strategies for Development of Antimalarials Based on Encapsulated Porphyrin Derivatives

2015 ◽  
Vol 14 (13) ◽  
pp. 1055-1071 ◽  
Author(s):  
Daiana Deda ◽  
Alexandre Budu ◽  
Laura Cruz ◽  
Koiti Araki ◽  
Celia Garcia
Keyword(s):  
Porphyrin Derivatives

Acyclic nucleoside phosphonates and human telomerase inhibition

2005 ◽  
Author(s):  
Miroslav Hájek ◽  
Naděžda Matulová ◽  
Ivan Votruba ◽  
Antonín Holý ◽  
Eva Tloušťová
Keyword(s):  
Telomerase Inhibition ◽  
Acyclic Nucleoside Phosphonates ◽  
Acyclic Nucleoside ◽  
Human Telomerase

scholarly journals Evaluation of the correlation between porphyrin accumulation in cancer cells and functional positions for application as a drug carrier

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Koshi Nishida ◽  
Toshifumi Tojo ◽  
Takeshi Kondo ◽  
Makoto Yuasa
Keyword(s):  
Cancer Cells ◽  
Drug Carrier ◽  
Bilayer Membrane ◽  
Phospholipid Bilayer ◽  
Membrane Permeation ◽  
Porphyrin Derivatives ◽  
Phospholipid Bilayer Membrane ◽  
Meso Position ◽  
Tumor Accumulation ◽  
Binding Position

AbstractPorphyrin derivatives accumulate selectively in cancer cells and are can be used as carriers of drugs. Until now, the substituents that bind to porphyrins (mainly at the meso-position) have been actively investigated, but the effect of the functional porphyrin positions (β-, meso-position) on tumor accumulation has not been investigated. Therefore, we investigated the correlation between the functional position of substituents and the accumulation of porphyrins in cancer cells using cancer cells. We found that the meso-derivative showed higher accumulation in cancer cells than the β-derivative, and porphyrins with less bulky substituent actively accumulate in cancer cells. When evaluating the intracellular distribution of porphyrin, we found that porphyrin was internalized by endocytosis and direct membrane permeation. As factors involved in these two permeation mechanisms, we evaluated the affinity between porphyrin-protein (endocytosis) and the permeability to the phospholipid bilayer membrane (direct membrane permeation). We found that the binding position of porphyrin affects the factors involved in the transmembrane permeation mechanisms and impacts the accumulation in cancer cells.

scholarly journals Solubilization of Charged Porphyrins in Interpolyelectrolyte Complexes: A Computer Study

Polymers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 502
Author(s):  
Karel Šindelka ◽  
Zuzana Limpouchová ◽  
Karel Procházka
Keyword(s):  
Dissipative Particle Dynamics ◽  
Water Soluble ◽  
Coarse Grained ◽  
Core Shell ◽  
Computer Study ◽  
Interpolyelectrolyte Complex ◽  
The Core ◽  
Porphyrin Derivatives ◽  
Oppositely Charged ◽  
Positively Charged

Using coarse-grained dissipative particle dynamics (DPD) with explicit electrostatics, we performed (i) an extensive series of simulations of the electrostatic co-assembly of asymmetric oppositely charged copolymers composed of one (either positively or negatively charged) polyelectrolyte (PE) block A and one water-soluble block B and (ii) studied the solubilization of positively charged porphyrin derivatives (P+) in the interpolyelectrolyte complex (IPEC) cores of co-assembled nanoparticles. We studied the stoichiometric mixtures of 137 A10+B25 and 137 A10−B25 chains with moderately hydrophobic A blocks (DPD interaction parameter aAS=35) and hydrophilic B blocks (aBS=25) with 10 to 120 P+ added (aPS=39). The P+ interactions with other components were set to match literature information on their limited solubility and aggregation behavior. The study shows that the moderately soluble P+ molecules easily solubilize in IPEC cores, where they partly replace PE+ and electrostatically crosslink PE− blocks. As the large P+ rings are apt to aggregate, P+ molecules aggregate in IPEC cores. The aggregation, which starts at very low loadings, is promoted by increasing the number of P+ in the mixture. The positively charged copolymers repelled from the central part of IPEC core partially concentrate at the core-shell interface and partially escape into bulk solvent depending on the amount of P+ in the mixture and on their association number, AS. If AS is lower than the ensemble average ⟨AS⟩n, the copolymer chains released from IPEC preferentially concentrate at the core-shell interface, thus increasing AS, which approaches ⟨AS⟩n. If AS>⟨AS⟩n, they escape into the bulk solvent.

scholarly journals Copolymers of bipyridinium and metal (Zn & Ni) porphyrin derivatives; theoretical insights and electrochemical activity towards CO2

RSC Advances ◽  
2021 ◽  
Vol 11 (32) ◽  
pp. 19844-19855
Author(s):  
Sachin Kochrekar ◽  
Ajit Kalekar ◽  
Shweta Mehta ◽  
Pia Damlin ◽  
Mikko Salomäki ◽  
...  
Keyword(s):  
Electrochemical Activity ◽  
Porphyrin Derivatives

Electropolymerization of keto functionalized porphyrins and 4,4′-bipyridine.

Sign in / Sign up

Export Citation Format

Share Document