Proteomic analysis of thyroid tissue reveals enhanced catabolic activity in Graves' disease compared to toxic multinodular goitre

2021 ◽  
Author(s):  
Duygu Temiz Karadag ◽  
Berrin Cetinarslan ◽  
Murat Kasap ◽  
Nuh Zafer Canturk ◽  
Gurler Akpinar ◽  
...  
Keyword(s):  
Proteomic Analysis ◽  
Thyroid Tissue ◽  
Graves Disease ◽  
Multinodular Goitre ◽  
Catabolic Activity

scholarly journals Proteomic analysis of thyroid tissue in Graves' disease and toxic multinodular goiter

2014 ◽  
Author(s):  
Duygu Temiz Karadag ◽  
Berrin Cetinarslan ◽  
Murat Kasap ◽  
Nuh Zafer Canturk ◽  
Gurler Akpinar ◽  
...  
Keyword(s):  
Proteomic Analysis ◽  
Multinodular Goiter ◽  
Thyroid Tissue ◽  
Graves Disease ◽  
Toxic Multinodular Goiter

Circulating TSH-binding inhibiting immunoglobulins in myasthenia gravis

1982 ◽  
Vol 101 (1) ◽  
pp. 41-46 ◽  
Author(s):  
W. R. Kiessling ◽  
R. Finke ◽  
P. Kotulla ◽  
H. Schleusener
Keyword(s):  
Myasthenia Gravis ◽  
Thyroid Tissue ◽  
Graves Disease ◽  
Thyroid Antibodies ◽  
Multinodular Goitre ◽  
Trh Stimulation ◽  
Receptor Assay ◽  
Pituitary Thyroid Axis ◽  
Thyroid Axis ◽  
Radioligand Receptor Assay

Abstract. Using a radioligand receptor assay the sera of 46 patients with myasthenia gravis (MG) were tested for the presence of circulating TSH-binding inhibiting immunoglobulins (TBII). In addition thyroid function was evaluated on the basis of T3, T4, TBG and TSH radioimmunoassays including the TRH stimulation test. Circulating antimicrosomal and antithyroglobulin thyroid antibodies were measured by haemagglutination techniques. Two patients had concomitant Graves' disease (GD), 5 were euthyroid with autonomously functioning thyroid tissue due to non-immunogenic multinodular goitre and 39 myasthenic patients were euthyroid with normal pituitary thyroid axis. Only 1 patient with GD had strongly positive TBII-activity and 3 euthyroid MG patients were TBII borderline-positive.

Relationship among T- and B-lymphocytes of the peripheral blood and thyroid tissue in patients with Graves' disease

2019 ◽  
Author(s):  
Margarita A Dudina ◽  
Andrey A Savchenko ◽  
Sergey A Dogadin ◽  
Alexandr G Borisov ◽  
Igor V Kudryavcev ◽  
...  
Keyword(s):  
B Lymphocytes ◽  
Peripheral Blood ◽  
Thyroid Tissue ◽  
T And B Lymphocytes ◽  
Graves Disease

scholarly journals Thyroid papillary carcinoma: preliminary evidence for a germ-line single nucleotide polymorphism in the Fas gene

2004 ◽  
Vol 182 (3) ◽  
pp. 479-484 ◽  
Author(s):  
F Basolo ◽  
R Giannini ◽  
P Faviana ◽  
G Fontanini ◽  
A Patricelli Malizia ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Germ Line ◽  
Thyroid Tissue ◽  
Preliminary Evidence ◽  
Graves Disease ◽  
Nucleotide Polymorphism ◽  
Single Strand Conformational Polymorphism ◽  
Single Nucleotide ◽  
N 93 ◽  
Immunohistochemical Studies

The expression of Fas in thyroid tumours and Graves' disease was analysed by mRNA transcript expression. As compared with unaffected thyroid tissue, Fas expression was enhanced in Graves' disease, adenomas, and papillary and follicular carcinomas. This pattern was also reflected in immunohistochemical studies. The PCR single-strand conformational polymorphism (SSCP) method and DNA sequencing were used to analyse Fas exons 1-9. The study was carried out on five different histotypes of thyroid tumours (n=93) and tissue from Graves' disease patients. As compared with a group of healthy blood donors (n=64), a significant association (P=0.006) emerged between papillary thyroid carcinoma and a silent single nucleotide polymorphism (SNP, 988C-->T) in exon 7 of the Fas gene. Other forms of thyroid pathology were not associated with the above polymorphism. Patients with neoplasia showed the same SNP in tumour tissue, in the unaffected contralateral thyroid lobe, and in peripheral blood cells. Thus, the 988C-->T polymorphism appeared to be of germ-line origin.

Type of operation for toxic adenoma, toxic multinodular goitre and Graves’ Disease

2015 ◽  
Vol 87 (1) ◽  
pp. 34-37 ◽  
Author(s):  
S. Lanitis ◽  
K. Karkoulias ◽  
G. Sourtse ◽  
V. Ganis
Keyword(s):  
Graves Disease ◽  
Multinodular Goitre ◽  
Toxic Adenoma
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