Distinct kinetics for nucleotide hydrolysis in lymphocytes isolated from blood, spleen and cervical lymph nodes: Characterization of ectonucleotidase activity

The Clinical and Histological Characterization of Malignant Lymphoma, Kikuchi-Fujimoto Disease and L-Forms Acid-Fast Bacillus Infection

Blood ◽

10.1182/blood.v112.11.5275.5275 ◽

2008 ◽

Vol 112 (11) ◽

pp. 5275-5275

Author(s):

Jie He ◽

Rui-ping Li ◽

Jian-hua Wang ◽

Bao-An Chen

Keyword(s):

Lymph Nodes ◽

Malignant Lymphoma ◽

Antibiotic Treatment ◽

Acid Fast Bacillus ◽

Cervical Region ◽

Excision Biopsy ◽

Cervical Lymph Nodes ◽

Inappropriate Treatment ◽

Acid Test

Abstract Objective: Malignant lymphoma (ML), Kikuchi-Fuljimoto disease (KFD) and L-forms Acid-fast bacillus infection (L-forms TB) usually affect the cervical lymph nodes. KFD and L-form TB are often confused with ML and take misdiagnosis and inappropriate treatment. The diagnosed of these diseases is on basis of an excision biopsy of affected lymph nodes. Methods: We analyzed 63 patients (including case diagnosed in our hospital) by clinical characteristic, laboratory, pathological morphology, histochemistry and immunohistochemistry. Results: Of 63 cases, 43 were ML, 17 were KFD and 3 were L-forms TB. In ML disease, 46% were male and 54% were female, mean age was 54 (11–82). 9% cases have persistent fever and associated with hepatosplenomegaly. In KFD, 47% were male and 53% were female, mean age was 26 (17–45). 59% cases with cervical hymphadenopath and no fever, 41% had painful, accompanied by fever. hepathosplenomegaly, occasionally leucopenia and lypadenopathy especially involving cervical region not responsive to antibiotic treatment. 29% lymph tissues were morphologically, and characterized by a necrosis in the cortical or paracortical areas of enlarged lymph node around the necrotic area. T lymphocytes were found and absence of granulocytes. 30% cases were mistaken to ML. L-forms TB disease, there were fever, clinical and histological were similar KFD and ML. 3 cases were misdiagnosis to ML or KFD. Laboratory analyses: PAM and PAS were positive, and anti acid test to found L-forms bacterium in tissues. Conclusions: Kikuchi-Fujimoto disease and L-forms Acid-Fast bacillus infection are easily confused histological and clinically with malignant lymphoma. Clinicians and pathologists must be aware of this condition. Although Malignant lymphoma, Kikuchi-Fujimoto disease and L-forms Acid-fast bacillus infection can be found any age, but should be considered for malignant lymphoma in older patients. Kikuchi-Fujimoto disease is predominantly a self-limiting disease of the young and most cases with fever, nodal biopsy showing fragmentation necrosis and karyorrhexis, not responsive to antibiotic treatment. In the L-forms Acid-fast bacillus infection, the PAM and PAS are positive, and have an effective antibiotic treatment.

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Characterization of cervical lymph-nodes using a multi-parametric and multi-modal approach for an early prediction of tumor response to chemo-radiotherapy

Physica Medica ◽

10.1016/j.ejmp.2016.09.003 ◽

2016 ◽

Vol 32 (12) ◽

pp. 1672-1680 ◽

Cited By ~ 13

Author(s):

Elisa Scalco ◽

Simona Marzi ◽

Giuseppe Sanguineti ◽

Antonello Vidiri ◽

Giovanna Rizzo

Keyword(s):

Lymph Nodes ◽

Tumor Response ◽

Early Prediction ◽

Cervical Lymph Nodes ◽

Modal Approach

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Characterization of cervical lymph nodes using DCE-MRI: Differentiation between metastases from SCC of head and neck and benign lymph nodes

Clinical Hemorheology and Microcirculation ◽

10.3233/ch-162065 ◽

2016 ◽

Vol 64 (2) ◽

pp. 213-222 ◽

Cited By ~ 12

Author(s):

Shuo Yan ◽

Zhiye Wang ◽

Li Li ◽

Yu Guo ◽

Xiaodong Ji ◽

...

Keyword(s):

Lymph Nodes ◽

Head And Neck ◽

Cervical Lymph Nodes ◽

Dce Mri

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Clinicopathologic Characterization of Canine Juvenile Cellulitis

Veterinary Pathology ◽

10.1177/030098588902600606 ◽

1989 ◽

Vol 26 (6) ◽

pp. 499-504 ◽

Cited By ~ 20

Author(s):

K. A. Reimann ◽

M. G. Evans ◽

L. V. Chalifoux ◽

S. Turner ◽

D. J. DeBoer ◽

...

Keyword(s):

Lymph Node ◽

Lymph Nodes ◽

Inflammatory Process ◽

Inflammatory Cell ◽

Light And Electron Microscopy ◽

Cervical Lymph Nodes ◽

Systemic Nature ◽

Dermal Lesions ◽

Infectious Etiology

The syndrome of canine juvenile cellulitis was observed and characterized throughout its clinical course when it occurred spontaneously in a litter of dogs. Histologically, pyogranulomatous inflammation was seen in facial skin and mandibular and superficial cervical lymph nodes of affected dogs. The predominant inflammatory cell characterized by light and electron microscopy and by immunohistochemical staining was an epithelioid macrophage. The same pyogranulomatous inflammatory process was seen in a lymph node anatomically distant from the site of apparent disease. Interestingly, a littermate with neither clinically evident dermal lesions nor lymphadenopathy had histologic evidence of a milder, but similar inflammatory process in a mandibular lymph node. The observation of canine juvenile cellulitis in clusters of dogs between 1 and 4 months of age and its apparent systemic nature suggest an infectious etiology. Bacterial, fungal, or viral agents were not isolated from affected lymph nodes. Attempts to transfer the disease by inoculation of neonatal puppies with tissue from affected dogs were also unsuccessful.

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Ultrasonographic characterization of cervical lymph nodes in healthy dogs

Veterinary Radiology & Ultrasound ◽

10.1111/vru.12784 ◽

2019 ◽

Vol 60 (5) ◽

pp. 560-566 ◽

Cited By ~ 1

Author(s):

Marissa J. Ruppel ◽

Rachel E. Pollard ◽

Jennifer L. Willcox

Keyword(s):

Lymph Nodes ◽

Cervical Lymph Nodes ◽

Healthy Dogs

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Diagnostic Value of Dual-Energy CT Iodine for Characterization of Papillary Thyroid Micro Carcinoma and Better Prediction of Metastatic Cervical Lymph Nodes

Iranian Journal of Radiology ◽

10.5812/iranjradiol.99924 ◽

2020 ◽

Vol In Press (In Press) ◽

Author(s):

YI-Long Huang ◽

Yuan-Ming Jiang ◽

Zheng-Hua Zhang ◽

Wen Zhao ◽

Yue Jiang ◽

...

Keyword(s):

Lymph Nodes ◽

Primary Tumor ◽

Diagnostic Value ◽

Dual Energy ◽

Morphological Features ◽

Dual Energy Ct ◽

Cervical Lymph Nodes ◽

Quantitative Parameters ◽

Venous Phase

Background: The preoperative assessment of cervical lymph node metastasis (LNM) is considered a challenging clinical problem in papillary thyroid microcarcinoma (PTMC) patients. Ultrasonic examination is significant for the cervical LNM in PTMC patients, but there are difficulties and limitations in observing lymph nodes in the cervical central region. Objectives: To investigate the diagnostic value of dual-energy CT iodine for characterization of PTMC and better prediction of metastatic cervical lymph nodes of PTMC. Patients and Methods: Ninety-five patients with PTMC who underwent dual energy (DE) CT examinations were retrospectively enrolled in the study. The iodine image morphological features of primary tumor were analyzed in the arterial phase and quantitative DECT parameters of the primary tumor were recorded in the arterial and venous phase. Chi-square test and independent-sample t test were performed to compare the differences of morphological features and quantitative parameters of tumors between LNM and non-LNM groups. Receiver operating characteristic curves were generated to assess the diagnostic performance of each DECT parameter and their combinations. Results: Six primary tumor morphological features of the LNM group demonstrated significant differences compared with the non-LNM group (all p < 0.05). Normalized iodine concentration (NIC) and normalized CT value in the LNM group were significantly higher than those of the non-LNM group in both arterial and venous phase, respectively (all p < 0.001). The area under the curve (AUC) was improved from 0.814 to 0.843 after adding maximum diameter compared with incomplete thyroid capsule alone. In addition, the combination of NICs in arterial and venous phases had higher AUC than other quantitative parameters. Conclusions: Morphological features and quantitative parameters of DECT are valuable for predicting cervical LNM in patients with PTMC.

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