Adiponectin antagonises LPS ‐regulated secretion of inflammatory factors in airway epithelial cells, and its expression is regulated by many factors

Author(s):  
Hu Liu ◽  
Huo‐yan Tang ◽  
Rui‐ying Wang ◽  
Jian‐ying Xu
2015 ◽  
Vol 21 (4) ◽  
pp. 403-409
Author(s):  
Kolsoum Rezaie-Kahkhaie ◽  
Shirin Emtenani ◽  
Shamsi Emtenani ◽  
Mohammad Doosti ◽  
Ahmad Asoodeh

2020 ◽  
Author(s):  
Ling Leng ◽  
Jie Ma ◽  
Leike Zhang ◽  
Wei Li ◽  
Lei Zhao ◽  
...  

AbstractThe outbreak of COVID-19 has caused serious epidemic events in China and other countries. With the rapid spread of COVID-19, it is urgent to explore the pathogenesis of this novel coronavirus. However, the foundational research of COVID-19 is very weak. Although angiotensin converting enzyme 2 (ACE2) is the reported receptor of SARS-CoV-2, information about SARS-CoV-2 invading airway epithelial cells is very limited. Based on the analysis of the Human Protein Atlas database, we compared the virus-related receptors of epithelial-derived cells from different organs and found potential key molecules in the local microenvironment for SARS-CoV-2 entering airway epithelial cells. In addition, we found that these proteins were associated with virus reactive proteins in host airway epithelial cells, which may promote the activation of the immune system and the release of inflammatory factors. Our findings provide a new research direction for understanding the potential microenvironment required by SARS-CoV-2 infection in airway epithelial, which may assist in the discovery of potential drug targets against SARS-CoV-2 infection.


Pneumologie ◽  
2015 ◽  
Vol 69 (07) ◽  
Author(s):  
S Ulrich ◽  
S Weinreich ◽  
R Haller ◽  
S Menke ◽  
R Olmer ◽  
...  

2010 ◽  
Vol 243 (3) ◽  
pp. 315-322 ◽  
Author(s):  
Aida Ibricevic ◽  
Steven L. Brody ◽  
Wiley J. Youngs ◽  
Carolyn L. Cannon

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