Modulation of age-related changes in oxidative stress markers and energy status in the rat heart and hippocampus: a significant role for ozone therapy

2012 ◽  
Vol 31 (6) ◽  
pp. 518-525 ◽  
Author(s):  
Maha M. El-Sawalhi ◽  
Hebatallah A. Darwish ◽  
Mohamed N. Mausouf ◽  
Amira A. Shaheen
2008 ◽  
Vol 85 (2) ◽  
pp. 135-140 ◽  
Author(s):  
Natsumi Hayakawa ◽  
Hironori Yokoyama ◽  
Hiroyuki Kato ◽  
Tsutomu Araki

2016 ◽  
Vol 103 (4) ◽  
pp. 428-438 ◽  
Author(s):  
M Stojanovic ◽  
V Zivkovic ◽  
I Srejovic ◽  
V Jakovljevic ◽  
N Jeremic ◽  
...  

This study aimed to assess the role of H2S in homocysteine-induced cardiodynamic effects in the isolated rat heart. The hearts were retrogradely perfused according to the Langendorff technique. The maximum and minimum rates of pressure in the left ventricle (dp/dt max, dp/dt min), systolic and diastolic left ventricular pressures (SLVP, DLVP), heart rate (HR), and coronary flow (CF) were measured. A spectrophotometrical method was used to measure the following oxidative stress markers: index of lipid peroxidation (thiobarbituric acid reactive substances, TBARS), nitrite level (NO2−), superoxide anion radicals (O2•−), and hydrogen peroxide (H2O2) concentrations. The administration of 10 µmol/l DL-homocysteine (DL-Hcy) alone decreased dp/dt max, SLVP, and CF but did not change any oxidative stress parameters. The administration of 10 µmol/l DL-propargylglycine (DL-PAG) decreased all cardiodynamic parameters and increased the concentration of O2•−. The co-administration of DL-Hcy and DL-PAG induced a significant decrease in all estimated cardiodynamic parameters and decreased the concentration of NO2− and O2•− but increased the levels of TBARS and H2O2. Homocysteine shows a lower pro-oxidative effect in the presence of hydrogen sulfide (H2S), which indicates a potential anti-oxidative capacity of H2S.


2020 ◽  
Vol 200 ◽  
pp. 108230
Author(s):  
P. Swathi Chitra ◽  
Debolina Chaki ◽  
Naveen K. Boiroju ◽  
Thirupathi R. Mokalla ◽  
Aruna K. Gadde ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document