Correlations between common tests for assessment of liver damage: Indices of the hepatoprotective activity of promethazine in carbon tetrachloride hepatotoxicity

1983 ◽  
Vol 1 (1) ◽  
pp. 55-63 ◽  
Author(s):  
Colin J. Reddrop ◽  
Kevin H. Cheeseman ◽  
T. F. Slater
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Hepatoprotective Activity ◽  
Damage Indices

Hepatoprotective activity ofTrichilia rokaon carbon tetrachloride-induced liver damage in rats

2001 ◽  
Vol 53 (11) ◽  
pp. 1569-1574 ◽  
Author(s):  
M. P. Germanò ◽  
V. D'Angelo ◽  
R. Sanogo ◽  
A. Morabito ◽  
S. Pergolizzi ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Hepatoprotective Activity

Hepatoprotective Activity of Hibiscus cannabinus (Linn.) Against Carbon Tetrachloride and Paracetamol Induced Liver Damage in Rats

2005 ◽  
Vol 8 (10) ◽  
pp. 1397-1401 ◽  
Author(s):  
Gabriel A. Agbor . ◽  
Julius E. Oben . ◽  
Blaise Nkegoum . ◽  
Jean Pierre Takala . ◽  
Jeanne Y. Ngogang .
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Hepatoprotective Activity ◽  
Hibiscus Cannabinus

scholarly journals Hepatoprotective Activity of the Total Saponins fromActinidia valvataDunn Root against Carbon Tetrachloride-Induced Liver Damage in Mice

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Liping Qu ◽  
Hailiang Xin ◽  
Guoyin Zheng ◽  
Yonghua Su ◽  
Changquan Ling
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Caspase 3 ◽  
Hepatoprotective Activity ◽  
Serum Marker ◽  
Acute Liver Damage ◽  
Inflammatory Infiltration ◽  
Liver Histopathology ◽  
Protein Expressions

The protective activity of the total saponins fromActinidia valvataDunn root (TSAV) was studied against carbon-tetrachloride- (CCl4-) induced acute liver injury in mice. Mice were orally administered TSAV (50, 100, and 200 mg/kg) for five days and then given CCl4. TSAV pretreatment significantly prevented the CCl4-induced hepatic damage as indicated by the serum marker enzymes (AST, ALT, and ALP). Parallel to these changes, TSAV also prevented CCl4-induced oxidative stress by inhibiting lipid peroxidation (MDA) and restoring the levels of antioxidant enzymes (SOD, CAT, GR, and GPX), GSH and GSSG. In addition, TSAV attenuated the serum TNF-αand IL-6 levels and inhibited the serum iNOS and NO levels. Liver histopathology indicated that TSAV alleviated CCl4-induced inflammatory infiltration and focal necrosis. TSAV (200 mg/kg) also significantly decreased Bak, Bax mRNA and Fas, FasL, p53, and NF-κB p65 protein expressions and increased Bcl-2 mRNA and protein expressions. Meanwhile, TSAV significantly downregulated caspase-3 and caspase-8 activities and prevented CCl4-induced hepatic cell apoptosis. In addition, TSAV exhibited antioxidant activity through scavenging hydroxyl and DPPH free radicalsin vitro. These results indicated that TSAV could protect mice against CCl4-induced acute liver damage possibly through antioxidant, anti-inflammatory activities and regulating apoptotic-related genes.

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