The virtosome-a novel cytosolic informative entity and intercellular messenger

2010 ◽  
Vol 28 (7) ◽  
pp. 529-538 ◽  
Author(s):  
Peter B. Gahan ◽  
Maurice Stroun
Keyword(s):  
Intercellular Messenger

Nitric Oxide: A Novel Intercellular Messenger in the Striatum

1994 ◽  
pp. 163-169
Author(s):  
Piers C. Emson ◽  
Rosalinda Guevara Guzman ◽  
Rosa Señaris ◽  
Jiro Kishimoto ◽  
Weiming Xu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Intercellular Messenger

Inducible NO synthase: role in cellular signalling

1999 ◽  
Vol 202 (6) ◽  
pp. 645-653 ◽  
Author(s):  
K.F. Beck ◽  
W. Eberhardt ◽  
S. Frank ◽  
A. Huwiler ◽  
U.K. Messmer ◽  
...  
Keyword(s):  
Gene Expression ◽  
No Synthase ◽  
Signalling Pathways ◽  
Target Cells ◽  
Activated Macrophages ◽  
The Past ◽  
Relaxing Factor ◽  
Endothelium Derived Relaxing Factor ◽  
Intercellular Messenger

The discovery of endothelium-derived relaxing factor and its identification as nitric oxide (NO) was one of the most exciting discoveries of biomedical research in the 1980s. Besides its potent vasodilatory effects, NO was found under certain circumstances to be responsible for the killing of microorganisms and tumour cells by activated macrophages and to act as a novel, unconventional type of neurotransmitter. In 1992, Science picked NO as the ‘Molecule of the Year’, and over the past years NO has become established as a universal intercellular messenger that acutely affects important signalling pathways and, on a more long-term scale, modulates gene expression in target cells. These actions will form the focus of the present review.

scholarly journals Modulation of swimming in the gastropod Melibe leonina by nitric oxide

2002 ◽  
Vol 205 (3) ◽  
pp. 397-403
Author(s):  
James M. Newcomb ◽  
Winsor H. Watson
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Marked Effect ◽  
Motor Program ◽  
No Donors ◽  
Histological Studies ◽  
The Central Nervous System ◽  
Oxide Synthase ◽  
Intercellular Messenger ◽  
Dependent Mechanism

SUMMARY Nitric oxide (NO) is a gaseous intercellular messenger produced by the enzyme nitric oxide synthase. It has been implicated as a neuromodulator in several groups of animals, including gastropods, crustaceans and mammals. In this study, we investigated the effects of NO on the swim motor program produced by isolated brains and by semi-intact preparations of the nudibranch Melibe leonina. The NO donors sodium nitroprusside (SNP, 1 mmol l–1) and S-nitroso-N-acetylpenicillamine (SNAP, 1 mmol l–1) both had a marked effect on the swim motor program expressed in isolated brains, causing an increase in the period of the swim cycle and a more erratic swim rhythm. In semi-intact preparations, the effect of NO donors was manifested as a significant decrease in the rate of actual swimming. An NO scavenger, reduced oxyhemoglobin, eliminated the effects of NO donors on isolated brains, supporting the assumption that the changes in swimming induced by donors were actually due to NO. The cGMP analogue 8-bromoguanosine 3′,5′-cyclic monophosphate (1 mmol l–1) produced effects that mimicked those of NO donors, suggesting that NO is working via a cGMP-dependent mechanism. These results, in combination with previous histological studies indicating the endogenous presence of nitric oxide synthase, suggest that NO is used in the central nervous system of Melibe leonina to modulate swimming.

Nitric Oxide Is Formed in a Subpopulation of Rat Pineal Cells and Acts as an Intercellular Messenger

1998 ◽  
Vol 68 (1) ◽  
pp. 57-63 ◽  
Author(s):  
Rainer Spessert ◽  
Elisabeth Layes ◽  
Gabriele Hill ◽  
Lutz Vollrath
Keyword(s):  
Nitric Oxide ◽  
Intercellular Messenger
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