Antioxidant effect of diphenyl diselenide on oxidative stress caused by acute physical exercise in skeletal muscle and lungs of mice

2009 ◽  
Vol 27 (4) ◽  
pp. 216-222 ◽  
Author(s):  
Marina Prigol ◽  
Cristiane Luchese ◽  
Cristina Wayne Nogueira
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Physical Exercise ◽  
Antioxidant Effect ◽  
Diphenyl Diselenide ◽  
Acute Physical Exercise

Anti-oxidative systems in rat skeletal muscle after acute physical exercise

2007 ◽  
Vol 32 (2) ◽  
pp. 190-196 ◽  
Author(s):  
José Alexandre Bachur ◽  
Sérgio Britto Garcia ◽  
Hélio Vannucchi ◽  
Alceu Afonso Jordao ◽  
Paula Garcia Chiarello ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Vitamin E ◽  
Weight Bearing ◽  
Antioxidant Defense System ◽  
Exercise Duration ◽  
The Body ◽  
Group A ◽  
Group B ◽  
Acute Physical Exercise

The objective of this study was to analyze the oxidative stress of skeletal muscle of sedentary rats at the morphological and biochemical level, due to acute physical effort performed at different intensities and during different periods of time. Forty-two male sedentary Wistar rats were divided into two groups, group A (swimming for 50 min) and group B (swimming for 100 min), which were further subdivided into 3 different exercise intensities, non-weight bearing (subgroup I), 3% weight load (subgroup II), and 5% weighted load (subgroup III), as well as a control-rested group (C). The animals were killed by ether inhalation and fragments of the gastrocnemius muscle were removed for the determination of malondialdehyde (MDA), reduced glutathione (GSH), and vitamin E concentrations. When all groups were compared with the control-rested group (C), gastrocnemius MDA levels at 50 and 100 min were higher at all swimming intensities. GSH consumption was greater at all intensities in group A, and only at 100 min in group BI; vitamin E consumption was significantly higher only in groups BII and BIII. When groups were compared by intensity at each swimming time there were no differences between I, II, and III at 50 min for any of the substances analyzed (MDA, GSH, and vitamin E), but at 100 min opposite effects were observed for GSH and vitamin E, with vitamin E consumption and GSH recovery occurring with increasing weight load. Higher concentrations of skeletal muscle MDA could indicate elevated lipid peroxidation at each time and exercise intensity, with highest MDA levels observed after the longest exercise duration and at the highest intensity. The layer-line mode of utilization of body antioxidants could explain the concentrations of GSH and vitamin E: first the use of GSH, even with minor oxidative stress, and then vitamin E consumption only in the presence of greater and more prolonged oxidative stress, indicating the necessity of adequate body levels of both antioxidants for proper utilization by the body antioxidant defense system.

Acute Physical Exercise Increases Glucose Uptake in Skeletal Muscle of Old Rats Through Rho-Kinase Metabolism

2016 ◽  
Vol 48 ◽  
pp. 578-579
Author(s):  
Vitor R. Muñoz ◽  
Inês S. Lima ◽  
Leandro P. Moura ◽  
Rafael C. Gaspar ◽  
Rania A. Mekary ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Physical Exercise ◽  
Glucose Uptake ◽  
Rho Kinase ◽  
Old Rats ◽  
Acute Physical Exercise

scholarly journals Skeletal muscle aging: influence of oxidative stress and physical exercise

Oncotarget ◽  
2017 ◽  
Vol 8 (12) ◽  
pp. 20428-20440 ◽  
Author(s):  
Mariana Janini Gomes ◽  
Paula Felippe Martinez ◽  
Luana Urbano Pagan ◽  
Ricardo Luiz Damatto ◽  
Marcelo Diacardia Mariano Cezar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Physical Exercise ◽  
Muscle Aging ◽  
Skeletal Muscle Aging

Physical exercise: An inducer of positive oxidative stress in skeletal muscle aging

Life Sciences ◽  
2020 ◽  
Vol 252 ◽  
pp. 117630 ◽  
Author(s):  
Anand Thirupathi ◽  
Ricardo A. Pinho ◽  
Yan-Zhong Chang
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Physical Exercise ◽  
Muscle Aging ◽  
Skeletal Muscle Aging

scholarly journals Combination of Coenzyme Q10 Intake and Moderate Physical Activity Counteracts Mitochondrial Dysfunctions in a SAMP8 Mouse Model

2018 ◽  
Vol 2018 ◽  
pp. 1-15 ◽  
Author(s):  
C. Andreani ◽  
C. Bartolacci ◽  
M. Guescini ◽  
M. Battistelli ◽  
V. Stocchi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Physical Exercise ◽  
Premature Aging ◽  
Moderate Physical Activity ◽  
Progressive Decline ◽  
Skeletal Muscle Mitochondria ◽  
High Degree ◽  
Samp8 Mice ◽  
Combined Intervention

Aging skeletal muscles are characterized by a progressive decline in muscle mass and muscular strength. Such muscular dysfunctions are usually associated with structural and functional alterations of skeletal muscle mitochondria. The senescence-accelerated mouse-prone 8 (SAMP8) model, characterized by premature aging and high degree of oxidative stress, was used to investigate whether a combined intervention with mild physical exercise and ubiquinol supplementation was able to improve mitochondrial function and preserve skeletal muscle health during aging. 5-month-old SAMP8 mice, in a presarcopenia phase, have been randomly divided into 4 groups (n=10): untreated controls and mice treated for two months with either physical exercise (0.5 km/h, on a 5% inclination, for 30 min, 5/7 days per week), ubiquinol 10 (500 mg/kg/day), or a combination of exercise and ubiquinol. Two months of physical exercise significantly increased mitochondrial damage in the muscles of exercised mice when compared to controls. On the contrary, ubiquinol and physical exercise combination significantly improved the overall status of the skeletal muscle, preserving mitochondrial ultrastructure and limiting mitochondrial depolarization induced by physical exercise alone. Accordingly, combination treatment while promoting mitochondrial biogenesis lowered autophagy and caspase 3-dependent apoptosis. In conclusion, the present study shows that ubiquinol supplementation counteracts the deleterious effects of physical exercise-derived ROS improving mitochondrial functionality in an oxidative stress model, such as SAMP8 in the presarcopenia phase.

scholarly journals Antioxidant Effect of a Probiotic Product on a Model of Oxidative Stress Induced by High-Intensity and Duration Physical Exercise

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 323
Author(s):  
Maravillas Sánchez Macarro ◽  
Vicente Ávila-Gandía ◽  
Silvia Pérez-Piñero ◽  
Fernando Cánovas ◽  
Ana María García-Muñoz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Physical Exercise ◽  
High Intensity ◽  
Bifidobacterium Longum ◽  
Protein Carbonyl ◽  
Antioxidant Effect ◽  
Mean Difference ◽  
Double Blind ◽  
Probiotic Group ◽  
Probiotic Product

This randomized double-blind and controlled single-center clinical trial was designed to evaluate the effect of a 6-week intake of a probiotic product (1 capsule/day) vs. a placebo on an oxidative stress model of physical exercise (high intensity and duration) in male cyclists (probiotic group, n = 22; placebo, n = 21). This probiotic included three lyophilized strains (Bifidobacterium longum CECT 7347, Lactobacillus casei CECT 9104, and Lactobacillus rhamnosus CECT 8361). Study variables were urinary isoprostane, serum malondialdehyde (MDA), serum oxidized low-density lipoprotein (Ox-LDL), urinary 8-hydroxy-2′-deoxiguanosine (8-OHdG), serum protein carbonyl, serum glutathione peroxidase (GPx), and serum superoxide dismutase (SOD). At 6 weeks, as compared with baseline, significant differences in 8-OHdG (Δ mean difference −10.9 (95% CI −14.5 to −7.3); p < 0.001), MDA (Δ mean difference −207.6 (95% CI −349.1 to −66.1; p < 0.05), and Ox-LDL (Δ mean difference −122.5 (95% CI −240 to −4.5); p < 0.05) were found in the probiotic group only. Serum GPx did not increase in the probiotic group, whereas the mean difference was significant in the placebo group (477.8 (95% CI 112.5 to 843.2); p < 0.05). These findings suggest an antioxidant effect of this probiotic on underlying interacting oxidative stress mechanisms and their modulation in healthy subjects. The study was registered in ClinicalTrials.gov (NCT03798821).

scholarly journals Effects of acute physical exercise on oxidative stress and inflammatory status in young, sedentary obese subjects

PLoS ONE ◽  
2017 ◽  
Vol 12 (6) ◽  
pp. e0178900 ◽  
Author(s):  
Francesca Accattato ◽  
Marta Greco ◽  
Salvatore A. Pullano ◽  
Ilaria Carè ◽  
Antonino S. Fiorillo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Physical Exercise ◽  
Inflammatory Status ◽  
Obese Subjects ◽  
Acute Physical Exercise

scholarly journals Preterm birth and oxidative stress: Effects of acute physical exercise and hypoxia physiological responses

Redox Biology ◽  
2018 ◽  
Vol 17 ◽  
pp. 315-322 ◽  
Author(s):  
Agnès Martin ◽  
Camille Faes ◽  
Tadej Debevec ◽  
Chantal Rytz ◽  
Grégoire Millet ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Preterm Birth ◽  
Physical Exercise ◽  
Physiological Responses ◽  
Stress Effects ◽  
Acute Physical Exercise ◽  
And Oxidative Stress

4,4’-Dichloro-diphenyl diselenide modulated oxidative stress that affected differently peripheral tissues in streptozotocin-exposed mice

2021 ◽  
Author(s):  
Luiza Souza Marques ◽  
Vanessa Angonesi Zborowski ◽  
Suelen Osório Heck ◽  
Bruna da Cruz Weber Fulco ◽  
Cristina Wayne Nogueira
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Aminolevulinic Acid ◽  
Protein Carbonyl ◽  
Diphenyl Diselenide ◽  
Diabetic Mice ◽  
Sod Activity ◽  
Peripheral Tissues ◽  
Diabetes Model ◽  
Liver And Kidney

Streptozotocin (STZ) is a substance used experimentally to induce a diabetes model, a metabolic disease associated with oxidative tissue damage. This study evaluated if dichloro-diphenyl diselenide (p-ClPhSe)2 modulates oxidative stress in peripheral tissues of diabetic mice. Male Swiss mice received a single STZ injection (i.p) at a dose of 200 mg/kg or its vehicle and were treated with (p-ClPhSe)2 (7 days, 5 mg/kg) or metformin (200 mg/kg, 2x/day). After, the mice were euthanized to collect liver, kidney, and skeletal muscle samples. In the liver, (p-ClPhSe)2 reduced TBARS and protein carbonyl levels and normalized the SOD activity in STZ-treated mice. In the kidney, (p-ClPhSe)2 reversed the increase in the reactive species levels but not the CAT activity reduction in STZ-treated mice. There was no evidence of oxidative damage in the skeletal muscle of STZ-treated mice, but an increase in the CAT activity and a reduction in non-protein thiol levels were found. (p-ClPhSe)2 did not reverse a decrease in hepatic and renal δ-aminolevulinic acid dehydratase activity in STZ-treated mice. The results show that the liver and kidney of STZ-treated mice were more susceptible to oxidative stress. This study reveals that (p-ClPhSe)2 modulated oxidative stress, which differently affected peripheral tissues of diabetic mice.

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