Protective effect of glycine supplementation on the levels of lipid peroxidation and antioxidant enzymes in the erythrocyte of rats with alcohol-induced liver injury

2004 ◽  
Vol 22 (2) ◽  
pp. 123-128 ◽  
Author(s):  
R. Senthilkumar ◽  
M. Sengottuvelan ◽  
N. Nalini
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Enzymes ◽  
Liver Injury ◽  
Protective Effect

Anti-hepatotoxic effects of 3,4-methylenedioxyphenol and N-acetylcysteine in acutely acetaminophen-overdosed mice

2011 ◽  
Vol 30 (10) ◽  
pp. 1609-1615 ◽  
Author(s):  
Victor Raj Mohan Chandrasekaran ◽  
Se-Ping Chien ◽  
Dur-Zong Hsu ◽  
Ming-Yie Liu
Keyword(s):  
Lipid Peroxidation ◽  
Liver Injury ◽  
Protective Effect ◽  
Liver Damage ◽  
Alanine Transaminase ◽  
Aspartate Transaminase ◽  
Hepatic Glutathione ◽  
Hepatotoxic Effect

3,4-Methylenedioxyphenol (sesamol) is effective against acetaminophen-induced liver injury in rats. Whether sesamol’s anti-hepatotoxic effect is comparable to that of N-acetylcysteine has never been studied. We investigated the anti-hepatotoxic effects of sesamol and N-acetylcysteine on acetaminophen-induced hepatotoxicity in mice. Equimolar doses (1 mmol/kg) of sesamol and N-acetylcysteine significantly inhibited acetaminophen (300 mg/kg)-increased serum aspartate transaminase and alanine transaminase levels 6 h post-administration. Sesamol and N-acetylcysteine maintained hepatic glutathione levels and inhibited lipid peroxidation. Moreover, the combination of sesamol and N-acetylcysteine antagonistically inhibited sesamol’s protection against acetaminophen-induced liver injury. We conclude that the protective effect of sesamol against acetaminophen-induced liver damage is comparable to that of N-acetylcysteine by maintaining glutathione levels and inhibiting lipid peroxidation in mice.

Favourable influence of low molecular weight heparin in mitigating the peroxidative membrane damage induced by a cytotoxic agent and an atherogenic diet

2003 ◽  
Vol 22 (5) ◽  
pp. 229-235 ◽  
Author(s):  
P R Deepa ◽  
P Varalakshmi
Keyword(s):  
Lipid Peroxidation ◽  
Molecular Weight ◽  
Antioxidant Enzymes ◽  
Protective Effect ◽  
Erythrocyte Membrane ◽  
Low Molecular Weight Heparin ◽  
Atherogenic Diet ◽  
Control Group ◽  
Low Molecular Weight ◽  
Cholesterol Levels

The present study is aimed to demonstrate the protective effect of a heparin derivative, low molecular weight heparin (LMWH) against erythrocyte membrane injury. Two models serve to induce membrane lipid peroxidative damage, namely a potent cytotoxic agent, adriamycin and a hypercholesterolemic atherogenic diet. Two groups of male Wistar rats (1409-10 g) received a single intravenous injection of adriamycin (ADR, 7.5 mg/kg), while two other groups were fed an atherogenic diet comprising a supplementation of 4% cholesterol, 1% cholic acid and 0.5% thiouracil (CCT diet) for 2 weeks. For each of the above two groups, LMWH (Troparin; 300 mg/day per rat subcutaneously) treatment commenced on day 8 and continued for a week. One group was maintained as the normal control group, and another group that received only LMWH treatment was designated as the LMWH drug control group. Erythrocyte membrane was isolated and assayed for its cholesterol levels, lipid peroxidation and ATPases activity. The activities of antioxidant enzymes were assessed in the haemolysate. The findings of the study were that both adriamycin and the atherogenic diet produced elevated membrane cholesterol levels and lipid peroxidation. The membrane ATPases suffered loss in activity. Accentuated oxidative stress was marked by rise in the activities of antioxidant enzymes (SOD, catalase and GPx). LMWH intervention reverted these changes thereby normalizing the membrane composition and function. The membrane protective effect of LMWH is illuminated by this work.

Protective effect of curcumin against lead neurotoxicity in rat

2003 ◽  
Vol 22 (12) ◽  
pp. 653-658 ◽  
Author(s):  
Pradeep K Shukla ◽  
Vinay K Khanna ◽  
Mohd Y Khan ◽  
Rikhab C Srimal
Keyword(s):  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Antioxidant Enzymes ◽  
Protective Effect ◽  
Corpus Striatum ◽  
Reduced Glutathione ◽  
Antioxidant Property ◽  
Brain Regions ◽  
Lead Levels ◽  
The Brain

Curcumin (diferuloylmethane), an active ingredient of turmeric, is known to have multiple activities, including an antioxidant property, and has been suggested to be of use in treatment of several diseases. The present study has been undertaken to investigate the protective effect of curcumin against lead-induced neurotoxicity in rats. Exposure of rats to lead (50 mg/kg po) for 45 days caused an increase in lipid peroxidation (LPO) and a decrease in reduced glutathione (GSH) levels in cerebellum, corpus striatum, hippocampus and frontal cortex as compared with controls. Lead levels were significantly increased in these rats. Activity of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) decreased in all the brain regions following lead exposure. Interestingly, cotreatment with curcumin (100 mg/kg po) and lead (50 mg/kg po) for 45 days caused a significant decrease in LPO with concomitant decrease in lead levels in all the brain regions as compared with those treated with lead alone. A significant increase in reduced glutathione (GSH) levels, SOD and CAT activities was also observed in all the four brain regions in rats simultaneously treated with curcumin and lead. The results suggest that curcumin may prevent lead-induced neurotoxicity.

scholarly journals Rutaecarpine Protects against Acetaminophen-Induced Acute Liver Injury in Mice by Activating Antioxidant Enzymes

Antioxidants ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 86
Author(s):  
Jae Ho Choi ◽  
Sun Woo Jin ◽  
Gi Ho Lee ◽  
Eun Hee Han ◽  
Yong Pil Hwang ◽  
...  
Keyword(s):  
Antioxidant Enzymes ◽  
Liver Injury ◽  
Protective Effect ◽  
Acute Liver Injury ◽  
Glutathione Depletion ◽  
Dependent Manner ◽  
Evodia Rutaecarpa ◽  
Malondialdehyde Content ◽  
Cyp2e1 Expression ◽  
Dose Dependent

Rutaecarpine, an indolopyridoquinazolinone alkaloid isolated from the unripe fruit of Evodia rutaecarpa, is used to treat hypertension, postpartum hemorrhage, dysentery, and amenorrhea as a traditional medicine in Asia. We investigated the effect of rutaecarpine on acetaminophen-induced hepatotoxicity in mice. Rutaecarpine was administered orally daily for seven consecutive days, followed by intraperitoneal injection of acetaminophen in mice on day seven to induce hepatotoxicity. Rutaecarpine pretreatment significantly decreased acetaminophen-induced serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) activities and hepatic malondialdehyde content and prevented acetaminophen-induced hepatic glutathione depletion. Furthermore, CYP2E1 expression was decreased by rutaecarpine pretreatment in a dose-dependent manner. Rutaecarpine pretreatment inhibited acetaminophen-induced expression of inflammatory cytokines by inhibiting NF-κB activation by JNK1/2. Also, rutaecarpine pretreatment promoted Nrf2-mediated activation of the antioxidant enzymes GCLC, HO-1, and NQO1. This indicates that the protective effect of rutaecarpine during acetaminophen-induced acute liver injury is mediated by the activation of antioxidant enzymes. Therefore, rutaecarpine has a protective effect of APAP-induced liver damage.

Protective effect of Polygonum odoratum L. on acetaminophen-induced liver injury in rats

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
N Somparn ◽  
S Saenthaweesuk ◽  
R Jitvaropas ◽  
A Thuppia ◽  
J Kaulpiboon
Keyword(s):  
Liver Injury ◽  
Protective Effect
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