Prolonged effect of a single serotonin treatment in adult age on the serotonin and histamine content of white blood cells and mast cells of rats

2003 ◽  
Vol 21 (2) ◽  
pp. 191-194 ◽  
Author(s):  
G. Csaba ◽  
P. Kovács ◽  
Éva Pállinger
Keyword(s):  
Mast Cells ◽  
Blood Cells ◽  
White Blood Cells ◽  
Histamine Content ◽  
Adult Age ◽  
Prolonged Effect

scholarly journals Redefining true leukocytosis in the traumatic lumbar puncture

2015 ◽  
Vol 42 (S1) ◽  
pp. S30-S30
Author(s):  
SA Rizvi ◽  
F Moein-Afshari
Keyword(s):  
Lumbar Puncture ◽  
Blood Cells ◽  
White Blood Cells ◽  
Pediatric Age ◽  
Correction Formula ◽  
Adult Age ◽  
Delayed Treatment ◽  
L Protein ◽  
The Relationship ◽  
Compare And Contrast

Objective: To compare and contrast the observed versus predicted number of white blood cells (WBCs) in a traumatic cerebrospinal fluid (CSF) sample in children and adults. Background: Clinicians rely on a correction formula (Predicted_CSF_WBC=CSF_RBC×Blood_WBC/Blood_RBC) to determine if a true CSF leukocytosis exists. This formula may overestimate true CSF leukocytosis and lead to delayed treatment of meningitis. Methods: A retrospective review of CSF data of 105 patients who met the following criteria: 1) CSF from lumbar puncture (LP) contained≥1000 RBC/mm^3 and 2) CBC performed≤24 hours of LP; 3) negative CSF cultures. Regression analysis was performed to determine the relationship between actual and predicted CSF WBC values. Results: Regression modeling indicated a discrepancy in the predicted versus actual WBC values. Mean adult age was 48.9 years; CSF profile (mean WBC 146.3×10^6/L; RBC 17374×10^6/L; glucose 4.1 mmol/L; protein 1.4 g/L); mean peripheral WBC was 8.2×10^9/L; RBC 3.9×10^9/L. Mean pediatric age was 1.4 years; CSF profile (mean WBC 171.8x10^6/L; RBC 41763x10^6/L; glucose 2.7 mmol/L; protein 1.7 g/L); mean peripheral WBC was 12×10^9/L; RBC 7.2×10^9/L. Observed LP CSF WBC value was 47% of predicted (r^2=0.54 pediatric cohort; r^2=0.91 adults). Conclusion: True CSF leukocytosis could be missed in a traumatic CSF sample based on a currently applied correction formula. We propose the following modifcation: Observed_CSF_WBC=0.5x[CSF_RBC×Blood_WBC/Blood_RBC].

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