Potential of Nociceptin/Orphanin FQ Peptide Analogs for Drug Development

2020 ◽  
Author(s):  
Karol Wtorek ◽  
Anna Janecka
Keyword(s):  
Drug Development ◽  
Orphanin Fq ◽  
Peptide Analogs

scholarly journals Gut Peptides: Targets for Antiobesity Drug Development?

Endocrinology ◽  
2009 ◽  
Vol 150 (6) ◽  
pp. 2526-2530 ◽  
Author(s):  
Timothy H. Moran ◽  
Megan J. Dailey
Keyword(s):  
Drug Development ◽  
Multiple Roles ◽  
Gastrointestinal Function ◽  
Gut Peptides ◽  
Multiple Systems ◽  
Peptide Analogs ◽  
Peptide Release ◽  
Long Acting ◽  
Made In

Gut peptides play multiple roles in the controls of gastrointestinal function and in the initiation and termination of meals. Plasma levels of these peptides are differentially affected by the presence of nutrients in the digestive tract, and the patterns of peptide release are consistent with both their feeding stimulatory and inhibitory actions. A number of these peptide systems have been investigated as potential targets for antiobesity drug development. Progress has been made in developing long-acting peptide analogs and, in some cases, nonpeptide agonists and antagonists. Whether any individual approach will have significant long-term efficacy remains to be demonstrated. Approaches that target multiple systems may hold the most promise.

A update of botanical drug development in the United States: Status of applications

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
KM Wu ◽  
C Wu ◽  
J Dou ◽  
H Ghantous ◽  
S Lee ◽  
...  
Keyword(s):  
United States ◽  
Drug Development ◽  
The United States ◽  
Botanical Drug
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