The Effect of TIGAR Knockdown on Apoptotic and Epithelial‐Mesenchymal Markers Expression in Doxorubicin‐Resistant Non‐Small Cell Lung Cancer A549 Cell Lines

2020 ◽  
Author(s):  
Can Ali Agca ◽  
Mahinur Kırıcı ◽  
Victor S. Nedzvetsky ◽  
Ramazan Gundogdu ◽  
Artem A. Tykhomyrov
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lines ◽  
Cell Lung Cancer ◽  
A549 Cell ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancer A549 Cell

Effect of Umbelliferone on The Proliferation of Non Small Cell Lung Cancer A549 Cell

2020 ◽  
Vol 36 (1) ◽  
pp. 41-46
Author(s):  
Hyeji Han ◽  
◽  
SoonYoung Kwon ◽  
Hyebin Koh ◽  
Nisansala Chandimali ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
A549 Cell ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancer A549 Cell

scholarly journals MiR-1244 sensitizes the resistance of non-small cell lung cancer A549 cell to cisplatin

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Weili Li ◽  
Wenzhe Wang ◽  
Mingjian Ding ◽  
Xiaoliang Zheng ◽  
Shenglin Ma ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
A549 Cell ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancer A549 Cell

scholarly journals Genistein enhances the effect of cisplatin on the inhibition of non-small cell lung cancer A549 cell growth in vitro and in vivo

2014 ◽  
Vol 8 (6) ◽  
pp. 2806-2810 ◽  
Author(s):  
DEZHI LIU ◽  
LING YAN ◽  
LAN WANG ◽  
WEICHENG TAI ◽  
WEILI WANG ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Growth ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
A549 Cell ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancer A549 Cell

The Key microRNAs Regulated the Development of Non-small Cell Lung Cancer by Targeting TGF-β-induced epithelial–mesenchymal Transition

2019 ◽  
Vol 22 (4) ◽  
pp. 238-244 ◽  
Author(s):  
Gang Chen ◽  
Bo Ye
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lines ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Nsclc Cell ◽  
Normal Lung ◽  
Migration And Invasion ◽  
Small Cell Lung ◽  
Mesenchymal Transition

Purpose: Epithelial-to-Mesenchymal Transition (EMT) was reported to play a key role in the development of Non-Small Cell Lung Cancer (NSCLC). The process of EMT is regulated by the changes of miRNAs expression. However, it is still unknown which miRNA changed the most in the process of canceration and whether these changes played a role in tumor development. Methods: A total of 36 SCLC patients treated in our hospital between 11th, 2015 and 10th, 2017 were enrolled. The samples of cancer tissues and paracancer tissues of patients were collected and analyzed. Then, the miRNAs in normal lung cells and NSCLC cells were also analyzed. In the presence of TGF-β, we transfected the miRNA mimics or inhibitor into NSCLC cells to investigate the role of the significantly altered miRNAs in cell migration and invasion and in the process of EMT. Results: MiR-330-3p was significantly up-regulated in NSCLC cell lines and tissues and miRNA- 205 was significantly down-regulated in NSCLC cell lines and NSCLC tissues. Transfected miRNA-205 mimics or miRMA-330-3p inhibitor inhibited the migration and invasion of NCIH1975 cell and restrained TGF-β-induced EMT in NSCLC cells. Conclusion: miRNA-330-3p and miRNA-205 changed the most in the process of canceration in NSCLC. Furthermore, miR-330-3p promoted cell invasion and metastasis in NSCLC probably by promoting EMT and miR-205 could restrain NSCLC likely by suppressing EMT.

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