Aureonitols A and B, Two New C 13 ‐Polyketides from Chaetomium globosum , an Endophytic Fungus in Salvia miltiorrhiza

2019 ◽  
Vol 16 (9) ◽  
Author(s):  
Sheng‐Xiang Yang ◽  
Wen‐Ting Zhao ◽  
Heng‐Ye Chen ◽  
Lei Zhang ◽  
Ting‐Kai Liu ◽  
...  
Keyword(s):  
Endophytic Fungus ◽  
Salvia Miltiorrhiza ◽  
Chaetomium Globosum

scholarly journals Endophyte Chaetomium globosum D38 and its elicitors promote tanshinones accumulation of Salvia miltiorrhiza

2017 ◽  
Author(s):  
Xin Zhai ◽  
Dong Luo ◽  
Xiuqing Li ◽  
Ting Han ◽  
Zhouyang Kong ◽  
...  
Keyword(s):  
Hairy Root ◽  
Endophytic Fungi ◽  
Endophytic Fungus ◽  
Salvia Miltiorrhiza ◽  
Chaetomium Globosum ◽  
Primary Metabolism ◽  
Phenylpropionic Acid ◽  
Host Growth ◽  
Acid Accumulation ◽  
Plant Tissue Cultures

AbstractDue to the low yield of tanshinones and their analogues in Salvia miltiorrhiza, there are all kinds of stimulation strategies having been applied to improve tanshinones output in plant tissue cultures. Endophytic fungi have formed various different relationships with their host plants withstanding host and environmental factors, including symbiotic, mutualistic, commensalistic, and parasitic. Thus we take the assumption that endophytic fungi may be an emerging microbial tool used to promote secondary metabolism, which will promote the production of active compounds through endophyte-based biology method. Our study therefore aimed to examine the effects of live endophytic fungus Chaetomium globosum D38 and its elicitors on the accumulation of tanshinones in hairy root cultures of Salvia miltiorrhiza. C. globosum D38 mainly colonized in the intercellular gap of xylem parenchyma cells of S. miltiorrhiza hairy root, during long term co-existence without any toxicity against S. miltiorrhiza hairy root. Moreover, both of the live fungus and its mycelia extracts could induce the production of tanshinones, in special dihydrotanshinone I and cryptotanshinone. The effects of mycelia extracts were much stronger than that of the live fungus on tanshinones synthesis, which increased the transcriptional activity of genes with repect to tanshinone biosynthetic pathway obviously. Our results indicated that both of the live C. globosum D38 and its mycelia extracts could be utilized for tanshinones accumulation in S. miltiorrhiza hairy root. What’s more, D38 also could be made into biotic fertilizer applying into S.miltiorrhiza seddlings, which not only promoted host growth but the tanshinones and phenylpropionic acid accumulation. In the soil environment, D38 had formed bitrophic and mutual beneficial relationship with the host and enhanced the primary metabolism on the whole so as to have facilitative effects on phenylpropionic acid accumulation. To sum up, Chaetomium globosum D38 was a highly effective endophytic fungus for S. miltiorrhiza.

Antifungal metabolites from Chaetomium globosum, an endophytic fungus in Ginkgo biloba

2011 ◽  
Vol 39 (4-6) ◽  
pp. 876-879 ◽  
Author(s):  
Hu-Qiang Li ◽  
Xiao-Jun Li ◽  
You-Lin Wang ◽  
Qiang Zhang ◽  
An-Ling Zhang ◽  
...  
Keyword(s):  
Ginkgo Biloba ◽  
Endophytic Fungus ◽  
Chaetomium Globosum ◽  
Antifungal Metabolites

Bioactive metabolites from the desert plant-associated endophytic fungus Chaetomium globosum (Chaetomiaceae)

2021 ◽  
Vol 185 ◽  
pp. 112701
Author(s):  
Xiao-Yan Zhang ◽  
Xiang-Mei Tan ◽  
Meng Yu ◽  
Jian Yang ◽  
Bing-Da Sun ◽  
...  
Keyword(s):  
Endophytic Fungus ◽  
Chaetomium Globosum ◽  
Bioactive Metabolites ◽  
Desert Plant

scholarly journals Secondary Metabolites of the Endophytic Fungus Chaetomium globosum Isolated From Coptis chinensis

2021 ◽  
Vol 16 (9) ◽  
pp. 1934578X2110445
Author(s):  
Jia-Cheng Ji ◽  
Pan-Pan Wei ◽  
Xiao-Yang Han ◽  
Zheng-Hui Li ◽  
Hong-Lian Ai ◽  
...  
Keyword(s):  
Endophytic Fungus ◽  
Early Childhood Development ◽  
Childhood Development ◽  
Chaetomium Globosum ◽  
Resonance Spectroscopy ◽  
Ionization Mass ◽  
Two Dimensional ◽  
Coptis Chinensis ◽  
Relative Configuration ◽  
One Dimensional

A new steroid, chaetglotone (1), together with 3 known compounds (2-4), were isolated from Chaetomium globosum, which is an endophytic fungus isolated from the root of Coptis chinensis Franch . The new compound was characterized by one-dimensional and two-dimensional nuclear magnetic resonance spectroscopy and high-resolution electrospray ionization mass spectrometer. The relative configuration and absolute configuration of 1 were further determined via the DP4 + and Early Childhood Development protocols, separately.

Bioactive metabolites produced by Chaetomium globosum, an endophytic fungus isolated from Ginkgo biloba

2009 ◽  
Vol 19 (6) ◽  
pp. 1572-1574 ◽  
Author(s):  
Jian-Chun Qin ◽  
Ya-Mei Zhang ◽  
Jin-Ming Gao ◽  
Ming-Sheng Bai ◽  
Sheng-Xiang Yang ◽  
...  
Keyword(s):  
Ginkgo Biloba ◽  
Endophytic Fungus ◽  
Chaetomium Globosum ◽  
Bioactive Metabolites

ChemInform Abstract: Bioactive Metabolites Produced by Chaetomium globosum, an Endophytic Fungus Isolated from Ginkgo biloba.

ChemInform ◽  
2009 ◽  
Vol 40 (32) ◽  
Author(s):  
Jian-Chun Qin ◽  
Ya-Mei Zhang ◽  
Jin-Ming Gao ◽  
Ming-Sheng Bai ◽  
Sheng-Xiang Yang ◽  
...  
Keyword(s):  
Ginkgo Biloba ◽  
Endophytic Fungus ◽  
Chaetomium Globosum ◽  
Bioactive Metabolites

scholarly journals Chemical Constituents from an Endophytic Fungus Chaetomium Globosum Z1

2013 ◽  
Vol 8 (9) ◽  
pp. 1934578X1300800
Author(s):  
Chun-Yan Zhang ◽  
Xiao Ji ◽  
Xuan Gui ◽  
Bao-Kang Huang
Keyword(s):  
Cytotoxic Activity ◽  
Cell Lines ◽  
Endophytic Fungus ◽  
Chemical Constituents ◽  
2D Nmr ◽  
Chaetomium Globosum ◽  
Spectroscopic Methods ◽  
Esi Ms

A new ergosterol, 15β-hydroxyl-(22 E,24 R)-ergosta-3,5,8,22-tetraen-one (1), along with three known ergosterols, two known cytochalasins, and two known azapholines were isolated from Chaetomium globosum Z1. The structures of these compounds were elucidated on the basis of spectroscopic methods (HR-ESI-MS, 1D NMR, and 2D NMR). Compound 6 showed significant cytotoxic activity against A-549 and MG-63 cell lines with IC50 values of 6.96 and 1.73 μg/mL, respectively.

Polyhydroxylated steroids from an endophytic fungus, Chaetomium globosum ZY-22 isolated from Ginkgo biloba

Steroids ◽  
2009 ◽  
Vol 74 (9) ◽  
pp. 786-790 ◽  
Author(s):  
Jian-Chun Qin ◽  
Jin-Ming Gao ◽  
Ya-Mei Zhang ◽  
Sheng-Xiang Yang ◽  
Ming-Sheng Bai ◽  
...  
Keyword(s):  
Ginkgo Biloba ◽  
Endophytic Fungus ◽  
Chaetomium Globosum ◽  
Polyhydroxylated Steroids
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