Calmodulin Inhibitors fromAspergillus stromatoides

2013 ◽  
Vol 10 (3) ◽  
pp. 328-337 ◽  
Author(s):  
Martín González-Andrade ◽  
Paulina Del Valle ◽  
Martha L. Macías-Rubalcava ◽  
Alejandro Sosa-Peinado ◽  
María Del Carmen González ◽  
...  
Keyword(s):  
Calmodulin Inhibitors

Calmodulin Inhibitors from the Endophytic Fungus Sporormiella minimoides

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
M Leyte-Lugo ◽  
M Figueroa ◽  
M del Carmen González ◽  
R Mata
Keyword(s):  
Endophytic Fungus ◽  
Calmodulin Inhibitors

Calmodulin Inhibitors from Aspergillus stromatoides

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
P Del Valle ◽  
M González-Andrade ◽  
ML Macías-Rubalcava ◽  
R Mata
Keyword(s):  
Calmodulin Inhibitors

Effect of Calmodulin Inhibitors on Thyroid Hormone Secretion

1986 ◽  
pp. 325-329
Author(s):  
Akira Nakai ◽  
Akio Nagasaka ◽  
Takako Ohyama ◽  
Toshihiro Aono ◽  
Rumi Masunaga ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Secretion ◽  
Calmodulin Inhibitors

Stress fiber organization regulated by MLCK and Rho-kinase in cultured human fibroblasts

2001 ◽  
Vol 280 (6) ◽  
pp. C1669-C1679 ◽  
Author(s):  
Kazuo Katoh ◽  
Yumiko Kano ◽  
Mutsuki Amano ◽  
Kozo Kaibuchi ◽  
Keigi Fujiwara
Keyword(s):  
Kinase Inhibitors ◽  
Fluorescent Protein ◽  
Human Fibroblasts ◽  
Rho Kinase ◽  
Focal Adhesions ◽  
Stress Fiber ◽  
Stress Fibers ◽  
Fiber System ◽  
Rho Kinase Inhibitors ◽  
Calmodulin Inhibitors

To understand the roles of Rho-kinase and myosin light chain kinase (MLCK) for the contraction and organization of stress fibers, we treated cultured human foreskin fibroblasts with several MLCK, Rho-kinase, or calmodulin inhibitors and analyzed F-actin organization in the cells. Some cells were transfected with green fluorescent protein (GFP)-labeled actin, and the effects of inhibitors were also studied in these living cells. The Rho-kinase inhibitors Y-27632 and HA1077 caused disassembly of stress fibers and focal adhesions in the central portion of the cell within 1 h. However, stress fibers located in the periphery of the cell were not severely affected by the Rho-kinase inhibitors. When these cells were washed with fresh medium, the central stress fibers and focal adhesions gradually reformed, and within 3 h the cells were completely recovered. ML-7 and KT5926 are specific MLCK inhibitors and caused disruption and/or shortening of peripheral stress fibers, leaving the central fibers relatively intact even though their number was reduced. The calmodulin inhibitors W-5 and W-7 gave essentially the same results as the MLCK inhibitors. The MLCK and calmodulin inhibitors, but not the Rho-kinase inhibitors, caused cells to lose the spread morphology, indicating that the peripheral fibers play a major role in keeping the flattened state of the cell. When stress fiber models were reactivated, the peripheral fibers contracted before the central fibers. Thus our study shows that there are at least two different stress fiber systems in the cell. The central stress fiber system is dependent more on the activity of Rho-kinase than on that of MLCK, while the peripheral stress fiber system depends on MLCK.

Comparative effects of calmodulin inhibitors on calmodulin's hydrophobic sites and on the activation of cyclic nucleotide phosphodiesterase by calmodulin

1987 ◽  
Vol 36 (12) ◽  
pp. 1989-1996 ◽  
Author(s):  
Paul Schaeffer ◽  
Claire Luginer ◽  
Anny Follenius-Wund ◽  
Dominique Gerard ◽  
Jean-Claude Stoclet
Keyword(s):  
Cyclic Nucleotide ◽  
Cyclic Nucleotide Phosphodiesterase ◽  
Calmodulin Inhibitors
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