Small Chemicals, Bioactivation, and the Immune System – A Fragile Balance of i-Tox and Benefits?

2009 ◽  
Vol 6 (11) ◽  
pp. 2138-2143 ◽  
Author(s):  
Charlotte Esser ◽  
Bettina Jux
Keyword(s):  
Immune System ◽  
System A

Coronavirus disease 2019 in critically ill patients: can we re-program the immune system? A primer for Intensivists

2020 ◽  
Vol 86 (11) ◽  
Author(s):  
Fiorenza Ferrari ◽  
Federico Visconti ◽  
Mara De Amici ◽  
Angelo Guglielmi ◽  
Costanza N. Colombo ◽  
...  
Keyword(s):  
Immune System ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
System A

scholarly journals Prenatal and Perinatal Environmental Influences Shaping the Neonatal Immune System: A Focus on Asthma and Allergy Origins

2021 ◽  
Vol 18 (8) ◽  
pp. 3962
Author(s):  
Azahara María García-Serna ◽  
Elena Martín-Orozco ◽  
Trinidad Hernández-Caselles ◽  
Eva Morales
Keyword(s):  
Immune System ◽  
Immune Cell ◽  
Mode Of Delivery ◽  
Environmental Influences ◽  
Pet Ownership ◽  
System A ◽  
Neonatal Immune System ◽  
Chemical Factors ◽  
Asthma And Allergy

It is suggested that programming of the immune system starts before birth and is shaped by environmental influences acting during critical windows of susceptibility for human development. Prenatal and perinatal exposure to physiological, biological, physical, or chemical factors can trigger permanent, irreversible changes to the developing immune system, which may be reflected in cord blood of neonates. The aim of this narrative review is to summarize the evidence on the role of the prenatal and perinatal environment, including season of birth, mode of delivery, exposure to common allergens, a farming environment, pet ownership, and exposure to tobacco smoking and pollutants, in shaping the immune cell populations and cytokines at birth in humans. We also discuss how reported disruptions in the immune system at birth might contribute to the development of asthma and related allergic manifestations later in life.

The interplay between airway epithelium and the immune system – A primer for the respiratory clinician

2021 ◽  
Author(s):  
Jered Weinstock ◽  
Xilei Xu Chen ◽  
Gustavo Nino ◽  
Anastassios Koumbourlis ◽  
Deepa Rastogi
Keyword(s):  
Immune System ◽  
Airway Epithelium ◽  
System A
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