Reactions of {4-[Bis(2-chloroethyl)amino]phenyl}acetic Acid (Phenylacetic Acid Mustard) with 2′-Deoxyribonucleosides

2007 ◽  
Vol 4 (3) ◽  
pp. 406-423 ◽  
Author(s):  
Diana Florea-Wang ◽  
Inna Ijäs ◽  
Kristo Hakala ◽  
Jorma Mattinen ◽  
Juhani Vilpo ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Phenylacetic Acid ◽  
Phenyl Acetic Acid ◽  
Phenylacetic Acid Mustard

Molecular rearrangements. III. Thermal decomposition of some selected thioesters

1982 ◽  
Vol 60 (22) ◽  
pp. 2870-2875 ◽  
Author(s):  
Aboel-Magd A. Abdel-Wahab ◽  
Ahmed M. El-Khawaga ◽  
Mohamed T. Ismail
Keyword(s):  
Thermal Decomposition ◽  
Acetic Acid ◽  
Benzoic Acid ◽  
Phenylacetic Acid ◽  
Coupling Reactions ◽  
Phenyl Acetic Acid ◽  
Molecular Rearrangements ◽  
Homolytic Fission

Four selected thioesters (1–4) were prepared and pyrolyzed in the absence of promoters either alone or in isoquinoline solvent. These esters include benzyl thiobenzoate (1), phenyl phenylthioacetate (2), benzyl phenylthioacetate (3), and phenyl thiobenzoate (4). Pyrolysis of 1 gave mainly 2,3,4,5-tetraphenylthiophene in addition to benzene, biphenyl, benzyl thiol, and benzoic acid. Thermal decomposition of 1 under nitrogen gave benzaldehyde, benzil, and only a trace of benzoic acid in addition to the former products. Compound 2 afforded essentially toluene and dibenzyl in addition to benzene, biphenyl, phenyl sulphide, thiophenol, and phenyl acetic acid. Thermolysis of 3 gave toluene and stilbene beside small quantities of benzyl thiol and phenylacetic acid. Finally, thermal decomposition of 4 in isoquinoline gave benzene, biphenyl, phenyl sulphide, thianthrene, thiophenol, benzoic acid, and 1-phenylisoquinoline. H2S and CO are also produced in all cases. In these rearrangements, the C—S bonds undergo homolytic fission either simultaneously or selectively. No isomer redistribution precedes the coupling reactions. Plausible mechanisms for the above facts are proposed.

On-Demand Guest Release from MOF-5 Sealed with Nitrophenylacetic Acid Photocapping Groups

2019 ◽  
Author(s):  
Jingjing Yan ◽  
Rick Homan ◽  
Corrianna Boucher ◽  
Prem N. Basa ◽  
Katherine Fossum ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Crystal Violet ◽  
Dye Molecules ◽  
Phenyl Acetic Acid ◽  
On Demand ◽  
Crystal Violet Dye ◽  
Dye Diffusion ◽  
Triphenylacetic Acid

Recently, we demonstrated that triphenylacetic acid could be used to seal dye molecules within MOF-5, but guest release required digestion of the framework by treatment with acid. We prepared the sterically bulky photocapping group [bis-(3-nitro-benzyl)-amino]-(3-nitro-phenyl)-acetic acid (PC1) can prevent Crystal violet dye diffusion from inside MOF-5 until removed by photolysis.

On-Demand Guest Release from MOF-5 Sealed with Nitrophenylacetic Acid Photocapping Groups

2019 ◽  
Author(s):  
Jingjing Yan ◽  
Rick Homan ◽  
Corrianna Boucher ◽  
Prem N. Basa ◽  
Katherine Fossum ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Crystal Violet ◽  
Dye Molecules ◽  
Phenyl Acetic Acid ◽  
On Demand ◽  
Crystal Violet Dye ◽  
Dye Diffusion ◽  
Triphenylacetic Acid

Recently, we demonstrated that triphenylacetic acid could be used to seal dye molecules within MOF-5, but guest release required digestion of the framework by treatment with acid. We prepared the sterically bulky photocapping group [bis-(3-nitro-benzyl)-amino]-(3-nitro-phenyl)-acetic acid (PC1) can prevent Crystal violet dye diffusion from inside MOF-5 until removed by photolysis.

Larvicidal and ovicidal activities of phenyl acetic acid isolated from Streptomyces collinus against Culex quinquefasciatus Say and Aedes aegypti L. (Diptera: Culicidae)

2021 ◽  
pp. 108120
Author(s):  
Appadurai Daniel Reegan ◽  
Pachaiyappan Saravana Kumar ◽  
Antony Cruz Asharaja ◽  
Chitra Devi ◽  
Sithi Jameela ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Aedes Aegypti ◽  
Culex Quinquefasciatus ◽  
Phenyl Acetic Acid ◽  
Streptomyces Collinus

scholarly journals Metallkomplexe in Anorganischen Matrices, 5 [1] / Metal Complexes in Inorganic Matrices, 5 [1]

1991 ◽  
Vol 46 (6) ◽  
pp. 783-788 ◽  
Author(s):  
Christian Egger ◽  
Ulrich Schubert
Keyword(s):  
Acetic Acid ◽  
Metal Complexes ◽  
Phenylacetic Acid ◽  
Sol Gel ◽  
Rhodium Complex ◽  
Gel Processing ◽  
Inorganic Matrices

A heterogenized rhodium complex, prepared by sol-gel processing of Rh(CO)Cl[PPh2CH2CH2Si(OEt)3]2 and Si(OEt)4, is shown to catalyze the conversion of the silanes H4-nSiPh„ (n = 1 - 3) or (HMe2Si)2O to (poly)siloxanes by air or water. Using THF as a solvent, the silanoles Ph3SiOH or Ph2Si(OH)2 are obtained instead. The reaction of phenylacetic acid or acetic acid with HSiPh3 to give silyl esters is catalyzed by the same compound.

scholarly journals Interaction of homo-aza-steroidal ester of [p -[bis-(2-chloroethyl) amino]phenyl]acetic acid (ASE) with DNA of Ehrlich ascites tumor cells

FEBS Letters ◽  
1983 ◽  
Vol 153 (1) ◽  
pp. 194-198 ◽  
Author(s):  
A. Papageorgiou ◽  
I.G. Ivanov ◽  
G.G. Markov ◽  
S.I. Koliais ◽  
L. Boutis ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Tumor Cells ◽  
Ehrlich Ascites Tumor ◽  
Ehrlich Ascites Tumor Cells ◽  
Ascites Tumor ◽  
Phenyl Acetic Acid ◽  
Ehrlich Ascites

scholarly journals Impact of Fermentable Fibres on the Colonic Microbiota Metabolism of Dietary Polyphenols Rutin and Quercetin

2019 ◽  
Vol 16 (2) ◽  
pp. 292 ◽  
Author(s):  
Bahareh Mansoorian ◽  
Emilie Combet ◽  
Areej Alkhaldy ◽  
Ada L. Garcia ◽  
Christine Ann Edwards
Keyword(s):  
Gas Chromatography ◽  
Acetic Acid ◽  
Propionic Acid ◽  
Phenolic Acids ◽  
Gas Chromatography Mass Spectrometry ◽  
Phenyl Acetic Acid ◽  
Potential Health ◽  
Dietary Polyphenols ◽  
Colonic Microbiota ◽  
Phenyl Propionic Acid

Dietary fibre and polyphenols are both metabolised to short-chain fatty acids (SCFAs) and phenolic acids (PA) by the colonic microbiota. These may alter microbiota growth/diversity, but their interaction is not understood. Interactions between rutin and raftiline, ispaghula or pectin were investigated in human faecal batch cultures (healthy participants; 19–33 years, 4 males, 6 females, BMI 18.4–27.4) after a low (poly)phenol diet three days prior to study. Phenolic acids were measured by gas chromatography-mass spectrometry and SCFAs by gas chromatography-flame ionisation after 2, 4, 6, and 24 h. Rutin fermentation produced Phenyl acetic acid (PAA), 4-Hydroxy benzoic acid (4-OHBA), 3-Hydroxy phenyl acetic acid (3-OHPAA), 4-Hydroxy phenyl acetic acid (4-OHPAA), 3,4-Dihydroxy phenyl acetic acid (3,4-diOHPAA), 3-Hydroxy phenyl propionic acid (3-OHPPA), and 4-Hydroxy phenyl propionic acid (4-OHPPA). 3,4-DiOHPAA and 3-OHPAA were predominant at 6 h (1.9 ± 1.8 µg/mL, 2.9 ± 2.5 µg/mL, and 0.05 ± 0.0 µg/mL, respectively) and 24 h (5.5 ± 3.3 µg/mL, 3.1 ± 4.2 µg/mL, and 1.2 ± 1.6 µg/mL). Production of all PA except 3-OHPPA and 4-OHPPA was reduced by at least one fibre. Inhibition of PA was highest for rutin (8-fold, p < 0.01), then pectin (5-fold, p < 0.01), and ispaghula (2-fold, p = 0.03). Neither rutin nor quercetin had a detectable impact on SCFA production. These interactions should be considered when assessing dietary polyphenols and potential health benefits.

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