scholarly journals Long‐term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers

2016 ◽  
Vol 5 (6) ◽  
pp. 1341-1351
Author(s):  
Kirstine K. Søgaard ◽  
Dóra K Farkas ◽  
Lars Pedersen ◽  
Jennifer L. Lund ◽  
Reimar W. Thomsen ◽  
...  
Keyword(s):  
Gastrointestinal Cancers ◽  
Duodenal Ulcers ◽  
Gastric Or Duodenal Ulcers

A role for altered phagosome maturation in the long-term persistence ofHelicobacter pyloriinfection

2012 ◽  
Vol 303 (2) ◽  
pp. G169-G179 ◽  
Author(s):  
Glenn N. Borlace ◽  
Stacey J. Keep ◽  
Mark J. R. Prodoehl ◽  
Hilary F. Jones ◽  
Ross N. Butler ◽  
...  
Keyword(s):  
Immune Response ◽  
Host Immune Response ◽  
Human Gastric Mucosa ◽  
Phagosome Maturation ◽  
Duodenal Ulcers ◽  
Immune Effector ◽  
Effector Cells ◽  
Gastric Or Duodenal Ulcers ◽  
H Pylori

The vigorous host immune response that is mounted against Helicobacter pylori is unable to eliminate this pathogenic bacterium from its niche in the human gastric mucosa. This results in chronic inflammation, which can develop into gastric or duodenal ulcers in 10% of infected individuals and gastric cancer in 1% of infections. The determinants for these more severe pathologies include host (e.g., high IL-1β expression polymorphisms), bacterial [e.g., cytotoxicity-associated gene ( cag) pathogenicity island], and environmental (e.g., dietary nitrites) factors. However, it is the failure of host immune effector cells to eliminate H. pylori that underlies its persistence and the subsequent H. pylori-associated disease. Here we discuss the mechanisms used by H. pylori to survive the host immune response and, in particular, the role played by altered phagosome maturation.

scholarly journals The prognostic value of HOTAIR for predicting long-term prognosis of patients with gastrointestinal cancers

Medicine ◽  
2018 ◽  
Vol 97 (26) ◽  
pp. e11139 ◽  
Author(s):  
Yi Zhang ◽  
Li-juan Wang ◽  
Wei-feng Li ◽  
Xu Zhang ◽  
Xian-jin Yang
Keyword(s):  
Prognostic Value ◽  
Gastrointestinal Cancers ◽  
Long Term Prognosis

Proton pump inhibitors and upper gastrointestinal cancers

2019 ◽  
Vol 12 (9) ◽  
pp. 526-530
Author(s):  
Monica Kumar
Keyword(s):  
Gastric Cancer ◽  
General Practice ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Cost Effective ◽  
Gastrointestinal Cancers ◽  
Increased Risk ◽  
The Uk ◽  
Upper Gastrointestinal

Proton pump inhibitors (PPIs) were introduced in the 1980s. They are now one of the most commonly prescribed drugs in general practice. They are cost-effective when used correctly; however, PPIs are often used beyond accepted clinical indications. Recent published studies performed outside the UK have suggested that adverse effects are associated with long-term use of PPIs; in particular, an increased risk of gastric cancer. This article will aim to systematically assess the evidence and discuss its application to our clinical practice.

scholarly journals 783 – Long-Term Proton Pump Inhibitor Use and Risk of Gastrointestinal Cancers

2019 ◽  
Vol 156 (6) ◽  
pp. S-163
Author(s):  
Jeffrey K. Lee ◽  
Sophie A. Merchant ◽  
Jennifer L. Schneider ◽  
Charles P. Quesenberry ◽  
Douglas A. Corley
Keyword(s):  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Gastrointestinal Cancers

scholarly journals ABO blood group, secretor status and detection ofHelicobacter pyloriamong patients with gastric or duodenal ulcers

1991 ◽  
Vol 106 (2) ◽  
pp. 221-229 ◽  
Author(s):  
A. Mentis ◽  
C. C. Blackwell ◽  
D. M. Weir ◽  
C. Spiliadis ◽  
A. Dailianas ◽  
...  
Keyword(s):  
Duodenal Ulcer ◽  
Helicobacter Pylori ◽  
Gastric Ulcer ◽  
Blood Group ◽  
Local Population ◽  
Abo Blood Group ◽  
Duodenal Ulcers ◽  
Secretor Status ◽  
Gastric Or Duodenal Ulcers ◽  
H Pylori

SUMMARYPatients (454) referred for gastroscopy to the General Hospital of Athens were examined to determine (1) if non-secretors were over-represented among patients with ulcers and (2) is there was an association with ABO blood group or secretor status and carriage ofHelicobacter pylori.Compared with the local population, among patients with either gastric ulcer (51) or duodenal ulcer (96) there was a significant increase in the proportion of those who were blood group O (P< 0·025); however, there were no significant differences in the proportions of non-secretors.H. pyloriwas identified in 62 % of the 454 patients: 59·5 % of those without evidence of ulcers; 62·5 % of those with gastric ulcer; 88% of those with duodenal ulcer (P< 0·0005). These bacteria were cultured more often and in higher numbers from patients with duodenal ulcer (P< 0·025). There was no association between ABO blood group and prevalence ofH. pylori. The prevalence ofH. pyloriamong non-secretors with gastric ulcer (12·5%) was significantly lower than that for non-secretors with duodenal ulcer (100%) (P< 0·0005). This was not observed for secretors.

scholarly journals Friberg. End Results in gastric Surgery with Sjiecial Refereme to „Resection for Exclusion“. (Acta chir. Scand., vol. LXXVIII fase. I—III, P. 157—18)

1937 ◽  
Vol 33 (4) ◽  
pp. 506-506
Author(s):  
V. S. Mayat
Keyword(s):  
Gastric Surgery ◽  
Long Term Results ◽  
Duodenal Ulcers ◽  
Acta Chir ◽  
End Results

The author examined long-term results in 398 patients operated on for gastric and duodenal ulcers. In 68 cases. a resection was made with the shutdown of the gatekeeper according to Finsterer.

Sign in / Sign up

Export Citation Format

Share Document