scholarly journals Age‐specific clinicopathological characteristics and prognostic analysis of neuroendocrine carcinomas of the gallbladder

2021 ◽  
Author(s):  
Zhiwei Zhang ◽  
Tong Guo ◽  
Xiaorui Huang ◽  
Peng Xie ◽  
Lu Wang ◽  
...  
Keyword(s):  
Clinicopathological Characteristics ◽  
Prognostic Analysis ◽  
Neuroendocrine Carcinomas

scholarly journals Clinicopathological characteristics with EGFR, ALK, ROS1 genetic alternation and prognostic analysis of primary lymphoepithelioma-like carcinoma

2019 ◽  
Vol 8 (6) ◽  
pp. 2350-2356
Author(s):  
Yinchen Shen ◽  
Fang Hu ◽  
Bo Zhang ◽  
Changhui Li ◽  
Xueyan Zhang ◽  
...  
Keyword(s):  
Clinicopathological Characteristics ◽  
Prognostic Analysis

Gastric cancer in 112 young patients: clinicopathological characteristics and prognostic analysis

2013 ◽  
Vol 33 (8) ◽  
pp. 922-925
Author(s):  
Jian XU ◽  
Tian-hang LUO ◽  
Xiao-jun SHEN ◽  
Guo WEI ◽  
Li-ye MA ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Young Patients ◽  
Clinicopathological Characteristics ◽  
Prognostic Analysis

scholarly journals Systematic and Multi-Omics Prognostic Analysis of Lysine Acetylation Regulators in Glioma

2021 ◽  
Vol 8 ◽  
Author(s):  
Zewei Tu ◽  
Lei Wu ◽  
Haitao Luo ◽  
Jingying Li ◽  
Shigang Lv ◽  
...  
Keyword(s):  
Overall Survival ◽  
Enrichment Analysis ◽  
Clinicopathological Characteristics ◽  
Gene Set Enrichment Analysis ◽  
Lysine Acetylation ◽  
Consensus Clustering ◽  
Who Grade ◽  
Prognostic Analysis ◽  
Number Variation ◽  
Prognostic Stratification

Lysine acetylation modification, which has key roles in cellular homeostasis as well as cancer malignancy, is dynamically regulated by lysine acetylation regulators (LARs). In our study, we found that most of 33 evaluated LARs were differentially expressed among 1,125 gliomas grouped by different clinicopathological characteristics. Consensus clustering was applied to 33 LARs, resulting in three glioma subtypes (LA1, 2, and 3). The LA3 subgroup was associated with the poorest clinical outcome, higher WHO grade, fewer isocitrate dehydrogenase mutations, and lower frequency of 1p/19q codeletion. Furthermore, gene set enrichment analysis indicated that eight tumor hallmarks were highly enriched in the LA3 subgroup. These results suggested that LARs are significantly related to glioma malignancy. We then designed a LAR-signature based on 14 overall survival (overall survival)-related LARs, and showed that the LAR-signature possesses strong and independent prognostic value for glioma patients in both training and validation datasets. Moreover, by interrogating single nucleotide polymorphism and copy number variation (CNV) data in The Cancer Genome Atlas dataset, we found that higher score of our risk signature is correlated with the hypermutation status of gliomas and that HDAC1(1p) was one of the oncogenes lost in 1p/19q codeletion events, while SIRT2(19q) and EP300(22q) may act as tumor suppressors in gliomas with 19q or 22q deletions, respectively. In conclusion, LARs are critical for the malignant development of gliomas, and our results are useful for prognostic stratification and development of novel assessment strategies for the prognosis of glioma patients.

Clinicopathological characteristics and prognostic analysis of gastric cancer in the young adult in China

Tumor Biology ◽  
2010 ◽  
Vol 32 (3) ◽  
pp. 509-514 ◽  
Author(s):  
Miao-zhen Qiu ◽  
Zhi-qiang Wang ◽  
Dong-sheng Zhang ◽  
Hui-yan Luo ◽  
Zhi-wei Zhou ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Young Adult ◽  
Clinicopathological Characteristics ◽  
Prognostic Analysis

scholarly journals Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Paloma Cejas ◽  
Yingtian Xie ◽  
Alba Font-Tello ◽  
Klothilda Lim ◽  
Sudeepa Syamala ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Lines ◽  
Therapeutic Strategy ◽  
Single Cell Analysis ◽  
Clinicopathological Characteristics ◽  
Clinical Samples ◽  
Cell Analysis ◽  
Neuroendocrine Prostate Cancer ◽  
Neuroendocrine Carcinomas ◽  
Pdx Models

AbstractNeuroendocrine carcinomas (NEC) are tumors expressing markers of neuronal differentiation that can arise at different anatomic sites but have strong histological and clinical similarities. Here we report the chromatin landscapes of a range of human NECs and show convergence to the activation of a common epigenetic program. With a particular focus on treatment emergent neuroendocrine prostate cancer (NEPC), we analyze cell lines, patient-derived xenograft (PDX) models and human clinical samples to show the existence of two distinct NEPC subtypes based on the expression of the neuronal transcription factors ASCL1 and NEUROD1. While in cell lines and PDX models these subtypes are mutually exclusive, single-cell analysis of human clinical samples exhibits a more complex tumor structure with subtypes coexisting as separate sub-populations within the same tumor. These tumor sub-populations differ genetically and epigenetically contributing to intra- and inter-tumoral heterogeneity in human metastases. Overall, our results provide a deeper understanding of the shared clinicopathological characteristics shown by NECs. Furthermore, the intratumoral heterogeneity of human NEPCs suggests the requirement of simultaneous targeting of coexisting tumor populations as a therapeutic strategy.

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