scholarly journals B7‐1 and programmed cell death‐ligand 1 in primary and lymph node metastasis lesions of non‐small cell lung carcinoma

2021 ◽  
Author(s):  
Takehiro Yamada ◽  
Yasuhiro Miki ◽  
Miho Suzuki ◽  
Osamu Kondoh ◽  
Ryoko Saito‐Koyama ◽  
...  
Keyword(s):  
Cell Death ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Programmed Cell Death ◽  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Node Metastasis

Lymphatic vessel density is not associated with lymph node metastasis or survival in non-small cell lung carcinoma (NSCLC)

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 18008-18008
Author(s):  
V. M. Villaflor ◽  
L. Faoro ◽  
J. Hutto ◽  
J. Varalakshmi ◽  
K. Suzue ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Median Survival ◽  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Node Metastasis ◽  
Factor C

18008 Background: Angiogenesis is accepted as being essential for tumors to grow and metastasize to distant sites. Lymphatic metastasis is also an important means of tumor spread. Vascular endothelial growth factor C (VEGF-C) plays and important role in lymphangiogenesis and activates VEGFR (VEGF receptor)-3. Numerous studies suggest that tumor expression of VEGF-C is a significant prognostic factor in NSCLC. In non-small cell lung carcinoma (NSCLC), the relationship of lymphangiogenesis with lymph node metastasis and patient prognosis is unknown. Methods: A retrospective analysis of 78 patients who were diagnosed with NSCLC from 1987 to 2004 were analyzed for lymphatic vascular density (LVD). LVD was measured by use of D2–40 monoclonal antibody staining. Survival was assessed and Mantel-Cox and Wilcoxon signed rank tests were used for statistical analysis. Results: Intratumoral and peritumoral LVD was significantly higher than in the uninvolved adjacent lung, but showed no significant association with lymph node status at the time of tumor resection. Variables which appeared to affect survival in our study were the presence of lymph node metastasis (median survival 1,425 vs absence 467 days, p=0.002). The presence of VEGF staining inversely affected median survival (present 757 vs absent 1,944 days, p= 0.014). LVD ≤ 53 events per field 895 days vs >53 median survival 1,302 days, p+0.867. Survival appeared to not be affected by LVD. Conclusions: These data suggest that although lymphangiogenesis occurs in association with NSCLC, it may not be an important factor in lymph node metastasis or in survival. In fact, there is a suggestion that the number of lymphatics that a patient inherently has appears to be more important than lymphangiogenesis when it comes to the development of lymph node metastasis. No significant financial relationships to disclose.

Lymphatic Vessel Density Is Not Associated With Lymph Node Metastasis in Non–Small Cell Lung Carcinoma

2008 ◽  
Vol 132 (12) ◽  
pp. 1882-1888
Author(s):  
Leonardo Faoro ◽  
Joann Y. Hutto ◽  
Ravi Salgia ◽  
Shady A. El-Zayaty ◽  
Mark K. Ferguson ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Lung Carcinoma ◽  
Lymphatic Vessel ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Lymphatic Vessel Density ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Node Metastasis

Abstract Context.—Angiogenesis is essential for tumors to grow and metastasize. Lymphatic metastasis is also an important means of tumor spread. In non–small cell lung carcinoma, the relationship of lymphangiogenesis with lymph node metastasis and, ultimately, patient prognosis is unknown. Objective.—To evaluate whether lymphangiogenesis is related to lymph node metastasis and/or overall survival. Design.—Seventy-eight cases of non–small cell lung carcinoma diagnosed from 1987 to 2004 were retrospectively analyzed for intratumoral, peritumoral, and uninvolved adjacent lung tissue lymphatic vessel density (LVD) by D2-40 immunostaining. Lymphatics in 6 cases of squamous dysplasia/carcinoma in situ were similarly evaluated. Appropriate statistical methods were used. Results.—Intratumoral and peritumoral LVD was significantly higher than in the uninvolved adjacent lung but showed no significant association with lymph node stage at the time of tumor resection. Survival in patients with above average D2-40 values was not significantly different when compared with those who had below average values (median survival, 895 vs 1131 days; P = .97). Furthermore, patients with affected lymph nodes had significantly shorter survival (median survival, 467 vs 1425 days; P = .002). Overall, regardless of lymph node status, there was a significantly higher intratumoral (P < .001) and peritumoral (P < .001) LVD when compared with the adjacent uninvolved lung LVD. There was a trend toward increasing LVD with higher grade of squamous dysplasia. Conclusions.—The results suggest that although lymphangiogenesis occurs in association with non–small cell lung carcinoma, it may not be an important factor in lymph node metastasis. In fact, there is a suggestion that the number of lymphatics that a person inherently has appears to be more important than lymphangiogenesis when it comes to the development of lymph node metastasis.

scholarly journals Evaluation of lobar lymph node metastasis in non-small cell lung carcinoma using modified total lesion glycolysis

2018 ◽  
Vol 10 (12) ◽  
pp. 6932-6941
Author(s):  
Hitoshi Dejima ◽  
Hiroaki Kuroda ◽  
Yuko Oya ◽  
Noriaki Sakakura ◽  
Yoshitaka Inaba ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Total Lesion Glycolysis ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Node Metastasis
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