scholarly journals Novel human melanoma brain metastasis models in athymic nude fox1 nu mice: Site‐specific metastasis patterns reflecting their clinical origin

2021 ◽  
Author(s):  
Henrik A. Svendsen ◽  
Torstein R. Meling ◽  
Vigdis Nygaard ◽  
Stein Waagene ◽  
Hege Russnes ◽  
...  
Keyword(s):  
Brain Metastasis ◽  
Human Melanoma ◽  
Site Specific ◽  
Melanoma Brain Metastasis ◽  
Metastasis Models ◽  
Metastasis Patterns

scholarly journals Upregulation of cell surface GD3 ganglioside phenotype is associated with human melanoma brain metastasis

2020 ◽  
Vol 14 (8) ◽  
pp. 1760-1778
Author(s):  
Romela Irene Ramos ◽  
Matias A. Bustos ◽  
Jinfeng Wu ◽  
Peter Jones ◽  
Shu Ching Chang ◽  
...  
Keyword(s):  
Brain Metastasis ◽  
Cell Surface ◽  
Human Melanoma ◽  
Melanoma Brain Metastasis ◽  
Gd3 Ganglioside

Melanoma brain metastasis presentation, treatment, and outcomes in the age of targeted and immunotherapies

Cancer ◽  
2021 ◽  
Author(s):  
Evan D. Bander ◽  
Melissa Yuan ◽  
Joseph A. Carnevale ◽  
Anne S. Reiner ◽  
Katherine S. Panageas ◽  
...  
Keyword(s):  
Brain Metastasis ◽  
Melanoma Brain Metastasis

Low incidence of melanoma brain metastasis in the hippocampus

2014 ◽  
Vol 111 (1) ◽  
pp. 59-62 ◽  
Author(s):  
Angela M. Hong ◽  
Chao Suo ◽  
Michael Valenzuela ◽  
Lauren E. Haydu ◽  
Kari D. Jacobsen ◽  
...  
Keyword(s):  
Brain Metastasis ◽  
Melanoma Brain Metastasis ◽  
Low Incidence

scholarly journals Clinical Significance of PDCD4 in Melanoma by Subcellular Expression and in Tumor-Associated Immune Cells

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1049
Author(s):  
Thuy T. Tran ◽  
Chetan K. Rane ◽  
Christopher R. Zito ◽  
Sarah A. Weiss ◽  
Shlomit Jessel ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Brain Metastasis ◽  
Immune Cell ◽  
Tissue Microarrays ◽  
Pleckstrin Homology Domain ◽  
Neoplastic Progression ◽  
Melanoma Brain Metastasis ◽  
Pdcd4 Expression ◽  
Programmed Cell Death 4 ◽  
And Function

Little is known about the subcellular localization and function of programmed cell death 4 (PDCD4) in melanoma. Our past studies suggest PDCD4 interacts with Pleckstrin Homology Domain Containing A5 (PLEKHA5) to influence melanoma brain metastasis outcomes, as high intracranial PDCD4 expression leads to improved survival. We aimed to define the subcellular distribution of PDCD4 in melanoma and in the tumor microenvironment during neoplastic progression and its impact on clinical outcomes. We analyzed multiple tissue microarrays with well-annotated clinicopathological variables using quantitative immunofluorescence and evaluated single-cell RNA-sequencing on a brain metastasis sample to characterize PDCD4+ immune cell subsets. We demonstrate differences in PDCD4 expression during neoplastic progression, with high tumor and stromal PDCD4 levels associated with improved survival in primary melanomas and in intracranial metastases, but not in extracranial metastatic disease. While the expression of PDCD4 is well-documented on CD8+ T cells and natural killer cells, we show that it is also found on B cells and mast cells. PDCD4 expression in the tumor microenvironment is associated with increased immune cell infiltration. Further studies are needed to define the interaction of PDCD4 and PLEKHA5 and to evaluate the utility of this pathway as a therapeutic target in melanoma brain metastasis.

scholarly journals AKT1E17K Activates Focal Adhesion Kinase and Promotes Melanoma Brain Metastasis

2019 ◽  
Vol 17 (9) ◽  
pp. 1787-1800 ◽  
Author(s):  
David A. Kircher ◽  
Kirby A. Trombetti ◽  
Mark R. Silvis ◽  
Gennie L. Parkman ◽  
Grant M. Fischer ◽  
...  
Keyword(s):  
Brain Metastasis ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Melanoma Brain Metastasis
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