scholarly journals The prognostic value of preoperative serum lactate dehydrogenase levels in patients underwent curative‐intent hepatectomy for colorectal liver metastases: A two‐center cohort study

2021 ◽  
Author(s):  
Long Bai ◽  
Ze‐Yu Lin ◽  
Yun‐Xin Lu ◽  
Qin Chen ◽  
Han Zhou ◽  
...  
Keyword(s):  
Cohort Study ◽  
Lactate Dehydrogenase ◽  
Liver Metastases ◽  
Prognostic Value ◽  
Colorectal Liver Metastases ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
Curative Intent ◽  
Preoperative Serum

scholarly journals The Prognostic Value of Preoperative Serum Lactate Dehydrogenase (LDH) Levels in Patients Underwent Curative-intent Hepatectomy For Colorectal Liver Metastases: A Two-Center Cohort Study

2021 ◽  
Author(s):  
Long Bai ◽  
Ze-Yu Lin ◽  
Yun-Xin Lu ◽  
Qin Chen ◽  
Han Zhou ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lactate Dehydrogenase ◽  
Liver Metastases ◽  
Peer Review ◽  
Cancer Patients ◽  
Prognostic Value ◽  
Colorectal Liver Metastases ◽  
Curative Intent ◽  
Preoperative Serum ◽  
Colorectal Cancer Patients

Abstract Background. The prognostic value of lactate dehydrogenase (LDH) in colorectal cancer patients has remained inconsistent between non-metastatic and metastatic settings. So far, very few studies have included LDH in the prognostic analysis of curative-intent surgery for colorectal liver metastases (CRLM).Patients and Methods. 580 consecutive metastatic colorectal cancer patients who underwent curative-intent CRLM resection from Blinded for peer review (434 patients) and Blinded for peer review (146 patients) treated in 2000-2019 were enrolled. Overall survival (OS) was the primary endpoint. Cox regression model was performed to identify the prognostic values of preoperative serum LDH levels and other clinicopathology variables. A modification of the established Fong CRS scoring system comprising LDH was developed within this Chinese population.Results. At the median follow-up time of 60.5 months, and median OS was 59.5 months in the pooled cohort. In the multivariate analysis, preoperative LDH > upper limit of normal (250 U/L) was the strongest independent prognostic factor for OS (HR 1.73, 95% confidence interval [CI], 1.22-2.44; P < .001). Patients with elevated LDH levels showed impaired OS than patients with normal LDH levels (27.6 months vs. 68.8 months). Five-year survival rates were 53.7% and 22.5% in the LDH-normal group and LDH-high group, respectively. Similar results were also confirmed in each cohort. In the subgroup analysis, LDH could distinguish the survival regardless of most established prognostic factors (number and size of CRLM, surgical margin, extrahepatic metastases, CEA and CA19-9 levels, etc.). Integrating LDH into the Fong score contributed to an improvement in the predictive value. Conclusion. Our study implicates serum LDH as a reliable and independent laboratory biomarker to predict the clinical outcome of curative-intent surgery for CRLM. Composite of LDH and Fong score is a potential stratification tool for CRLM resection. Prospective, international studies are needed to validate these results across diverse populations.

scholarly journals Prognostic value of preoperative serum lactate dehydrogenase levels for resectable gastric cancer and prognostic nomograms

Oncotarget ◽  
2016 ◽  
Vol 7 (26) ◽  
pp. 39945-39956 ◽  
Author(s):  
Zi-Xian Wang ◽  
Lu-Ping Yang ◽  
Miao-Zhen Qiu ◽  
Zhi-Qiang Wang ◽  
Yi-Xin Zhou ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lactate Dehydrogenase ◽  
Prognostic Value ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
Preoperative Serum ◽  
Resectable Gastric Cancer

scholarly journals Prognostic value of preoperative serum lactate dehydrogenase in thymic carcinoma

2016 ◽  
Vol 8 (9) ◽  
pp. 2464-2472 ◽  
Author(s):  
Zu-Yang Yuan ◽  
Shu-Geng Gao ◽  
Ju-Wei Mu ◽  
Qi Xue ◽  
You-Sheng Mao ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Prognostic Value ◽  
Thymic Carcinoma ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
Preoperative Serum

scholarly journals The Prognostic Value of Preoperative Serum Lactate Dehydrogenase (LDH) Levels in Patients Underwent Curative-intent Hepatectomy For Colorectal Liver Metastases: A Two-Center Cohort Study

2021 ◽  
Author(s):  
Long Bai ◽  
Ze-Yu Lin ◽  
Yun-Xin Lu ◽  
Qin Chen ◽  
Han Zhou ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lactate Dehydrogenase ◽  
Cancer Patients ◽  
Prognostic Value ◽  
Colorectal Liver Metastases ◽  
Validation Cohort ◽  
Curative Intent ◽  
Training Cohort ◽  
Preoperative Serum ◽  
Colorectal Cancer Patients

Abstract Background: The prognostic value of lactate dehydrogenase (LDH) in colorectal cancer patients has remained inconsistent between non-metastatic and metastatic settings. So far very few studies have included LDH in prognostic analysis for patients with colorectal liver metastases (CRLM) who underwent curative-intent hepatectomy. Patients and Methods: Consecutive metastatic colorectal cancer patients who underwent curative-intent resection for CRLM from two Chinese medical centers treated in 2000-2019 were enrolled in the training cohort (434 patients) and the validation cohort (146 patients). Overall survival (OS) was the primary endpoint. Cox regression model was performed to identify the prognostic values of LDH and other clinicopathology variables. A modification of the established Fong scoring system comprising LDH was developed within this Chinese population.Results: In the training cohort, preoperative LDH > upper limit of normal (ULN) was the strongest independent prognostic factor both for RFS (HR 2.11, 95% confidence intervals [CIs], 1.54-2.89; P < .001) and OS (HR 2.41, 95% CI, 1.72-3.39; P < .001) in multivariate analysis. 5-year survival rates were 23.7% and 52.9% in the LDH > ULN group and LDH < ULN group, respectively. These data were also confirmed in the validation cohort and then in pooled cohort. Replacing carcinoembryonic antigen (CEA) with LDH in the Fong score contributed to an improvement in the predictive value.Conclusions: Preoperative serum LDH is a reliable and independent predictor for curative-intent CRLM resection. Composite of LDH and Fong score is a potential stratification tool for CRLM resection.

scholarly journals Prognostic Value of Serum Lactate Dehydrogenase in Renal Cell Carcinoma: A Systematic Review and Meta-Analysis

PLoS ONE ◽  
2016 ◽  
Vol 11 (11) ◽  
pp. e0166482 ◽  
Author(s):  
Jie Shen ◽  
Zhen Chen ◽  
Qianfeng Zhuang ◽  
Min Fan ◽  
Tao Ding ◽  
...  
Keyword(s):  
Systematic Review ◽  
Renal Cell Carcinoma ◽  
Lactate Dehydrogenase ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Prognostic Value ◽  
Meta Analysis ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase

scholarly journals 99: Prognostic Value of Pre-Treatment Serum Lactate Dehydrogenase in HPV-Related and HPV-Unrelated Oropharyngeal Cancer

2016 ◽  
Vol 120 ◽  
pp. S38-S39
Author(s):  
Shao Hui Sophie Huang ◽  
Scott V. Bratman ◽  
Jie Su ◽  
Li Tong ◽  
John Kim ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Oropharyngeal Cancer ◽  
Prognostic Value ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
Pre Treatment
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