scholarly journals Hearing loss and intellectual outcome in children treated for embryonal brain tumors: Implications for young children treated with radiation sparing approaches

2021 ◽  
Author(s):  
Iska Moxon‐Emre ◽  
Christine Dahl ◽  
Vijay Ramaswamy ◽  
Ute Bartels ◽  
Uri Tabori ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Young Children ◽  
Brain Tumors ◽  
Intellectual Outcome ◽  
Embryonal Brain

scholarly journals MEDU-34. INTELLECTUAL OUTCOME IN CHILDREN WITH SENSORINEURAL HEARING LOSS FOLLOWING TREATMENT FOR EMBRYONAL BRAIN TUMORS.

2017 ◽  
Vol 19 (suppl_4) ◽  
pp. iv44-iv45 ◽  
Author(s):  
Christine Dahl ◽  
Iska Moxon-Emre ◽  
Vijay Ramaswamy ◽  
Ute Bartels ◽  
Uri Tabori ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Brain Tumors ◽  
Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Intellectual Outcome ◽  
Embryonal Brain

Neurocognitive outcome in children with sensorineural hearing loss after treatment of malignant embryonal brain tumors.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 2029-2029
Author(s):  
Christine Dahl ◽  
Iska Moxon-Emre ◽  
Vijay Ramaswamy ◽  
Ute Katharina Bartels ◽  
Uri Tabori ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Brain Tumors ◽  
Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Verbal Language ◽  
Intellectual Function ◽  
Embryonal Brain ◽  
Mild Hearing Loss ◽  
The Impact

2029 Background: Neurological side effects associated with childhood brain tumors and their treatments contribute to long term neurocognitive morbidity. The aims of this study were to identify the incidence of sensorineural hearing loss (SNHL) in a large sample of children treated for malignant brain tumors, and to evaluate the potential relationship between SNHL and intellectual functioning following the completion of treatment. Methods: We conducted a prospective follow-up study at a single center with review of 119 patients treated for embryonal brain tumors at the Hospital for Sick Children, between 1996-2015, to analyze the impact of significant SNHL (Chang > 2b) on intellectual function. Hearing was assessed post-treatment (median age: 13.5y (+4.5)) and the median age for neurocognitive testing was 12.8y (+ 4.1). The median interval from time of diagnosis was 5.8y (+ 3.7). Results: Severe SNHL was identified in half the patients (50.4%, n = 60/119). We identified a subset of patients (n = 61) who had assessments of intellectual function. In this cohort, intellectual function was significantly poorer in the group with severe SNHL, even after controlling for the effect of craniospinal radiation (severe SNHL 22.4 Gy + 13.3, no or mild hearing loss 20.4 Gy +12.8) and boost dose and volume. Children experiencing severe SNHL had lower overall IQ (severe SNHL 72.4 + 16.6; no/mild hearing loss 92.0 + 20.5) p < 0.001 and in significantly lower verbal comprehension (severe SNHL 78.7 + 15.9; no/mild hearing loss 94.7 + 13.8) p < 0.001, and working memory (severe SNHL 78.2+ 17.6; no/mild hearing loss 94.8 + 16.4) p < 0.001, scores. Conclusions: Hearing loss is a much more significant complication in children with embryonal brain tumors than previously estimated. We show the profound impact of hearing loss on intellectual deficit in children. Namely, patients with severe SNHL have difficulty using and understanding verbal language, and they have a reduced ability to concentrate and manipulate information in short-term memory. Our results have implications on future trial designs and follow-up of children treated for embryonal brain tumors.

scholarly journals NCOG-12. NEUROCOGNITIVE OUTCOME IN CHILDREN WITH SENSORINEURAL HEARING LOSS FOLLOWING TREATMENT FOR MALIGNANT EMBRYONAL BRAIN TUMORS

2017 ◽  
Vol 19 (suppl_6) ◽  
pp. vi140-vi140
Author(s):  
Iska Moxon-Emre ◽  
Christine Dahl ◽  
Vijay Ramaswamy ◽  
Ute Bartels ◽  
Uri Tabori ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Brain Tumors ◽  
Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Neurocognitive Outcome ◽  
Embryonal Brain

scholarly journals PATH-08. THE IMPORTANCE OF RE-DIAGNOSIS OF TUMORS PREVIOUSLY CLASSIFIED AS CENTRAL NERVOUS SYSTEM PRIMITIVE NEUROECTODERMAL TUMORS

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii426-iii426
Author(s):  
Naohide Fujita ◽  
Osamu Akiyama ◽  
Akihide Kondo
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Brain Tumors ◽  
Easy Access ◽  
Molecular Analyses ◽  
Primitive Neuroectodermal Tumors ◽  
Neuroectodermal Tumors ◽  
Sanger Sequence ◽  
Embryonal Brain ◽  
Polymerase Chain

Abstract BACKGROUND The recent molecular analyses have revealed that central nervous system primitive neuroectodermal tumors (CNS PNETs) those having clusters of small round tumor cells are genetically different tumors. However, the concepts of CNS PNET are complicated, and it is difficult to diagnose them appropriately in clinical field. To overcome this difficulty, we reviewed previous studies associated with CNS PNETs, and carried out several approaches, those are relatively easy access to use in clinics, for our 8 samples of embryonal brain tumors diagnosed CNS PNETs in our institution, initially. METHODS We used in combination with immunohistochemistry (IHC), Sanger sequence, Pyrosequence, polymerase chain reaction (PCR), real time PCR and copy number analysis referring recent reports. RESULTS In terms of the diagnosis three out of 8 cases were changed based on the results in this study from previous diagnoses. CONCLUSION In this review, it seemed that either the histopathological evaluation or molecular analyses would be not enough to make accurate diagnosis of CNS embryonal brain tumors, and it is essential to combine both of them including recent comprehensive analysis methods.

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