scholarly journals A simple test‐based frailty index to predict survival among cancer patients with an unplanned hospitalization: An observational cohort study

2021 ◽  
Author(s):  
Timothy Hembree ◽  
Olga Theou ◽  
Sarah Thirlwell ◽  
Richard R. Reich ◽  
Biwei Cao ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cancer Patients ◽  
Frailty Index ◽  
Observational Cohort Study ◽  
Simple Test ◽  
Observational Cohort

scholarly journals Prospective observational cohort study of oesophagogastric cancer patients (POCOP): A Dutch nationwide cohort

2018 ◽  
Vol 29 ◽  
pp. viii234
Author(s):  
J.J. van Kleef ◽  
L.V. van de Poll-Franse ◽  
R.H. Verhoeven ◽  
M. Slingerland ◽  
J.P. Ruurda ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cancer Patients ◽  
Observational Cohort Study ◽  
Prospective Observational Cohort Study ◽  
Observational Cohort ◽  
Oesophagogastric Cancer

Preoperative Anxiety as a Predictor of Delirium in Cancer Patients: A Prospective Observational Cohort Study

2018 ◽  
Vol 43 (1) ◽  
pp. 134-142 ◽  
Author(s):  
Saho Wada ◽  
Hironobu Inoguchi ◽  
Ryoichi Sadahiro ◽  
Yutaka J. Matsuoka ◽  
Yosuke Uchitomi ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cancer Patients ◽  
Observational Cohort Study ◽  
Preoperative Anxiety ◽  
Prospective Observational Cohort Study ◽  
Observational Cohort

scholarly journals Prevalence and Prognostic Significance of Frailty in Gerontal Inpatients With Pre-clinical Heart Failure: A Subgroup Analysis of a Prospective Observational Cohort Study in China

2020 ◽  
Vol 7 ◽  
Author(s):  
Pei-Pei Zheng ◽  
Si-Min Yao ◽  
Jing Shi ◽  
Yu-Hao Wan ◽  
Di Guo ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cohort Study ◽  
Subgroup Analysis ◽  
Frailty Index ◽  
Observational Cohort Study ◽  
Prospective Observational Cohort Study ◽  
Frailty Phenotype ◽  
Observational Cohort ◽  
Clinical Heart Failure

Objective: To evaluate the prognostic value of frailty in gerontal pre-clinical heart failure (stage B heart failure, SBHF) inpatients.Background: The association between frailty and SBHF remains unknown.Methods: We conducted a subgroup analysis of a prospective observational cohort study on frailty. The previous study recruited 1,000 elderly inpatients who were consecutively admitted to a tertiary referral hospital in Beijing, China, from September 2018 to February 2019. The outcomes were all-cause death or readmission at 1-year follow-up. SBHF was diagnosed for asymptomatic cardiac structural or functional abnormalities. Frailty was assessed using the Comprehensive Geriatric Assessment-Frailty Index (CGA-FI).Results: Overall, 531 inpatients aged ≥65 years were deemed to have SBHF and followed up for 1 year. Of them, 34.5% exhibited frailty. During the follow-up period, all-cause death or readmission occurred in 157 (29.5%) participants. Of these participants, 36.6% (67/183) and 25.9% (90/348) belonged to the frail and non-frail groups, respectively (χ2 = 6.655, P = 0.010). Frailty, defined by the CGA-FI, rather than Fried frailty phenotype, could independently predict 1-year all-cause death or readmission (hazard ratio, 1.56; 95% confidence interval, 1.03–2.35; P = 0.034) and was more suitable for predicting all-cause death or readmission than N-terminal pro-B-type natriuretic peptide in female SBHF inpatients aged 80 years or over(AUCCGA−FI vs. AUCNT−proBNP 0.654 vs. 0.575, P = 0.017).Conclusions: Frailty is highly prevalent even among SBHF inpatients aged ≥65 years. The CGA-FI can independently predict 1-year all-cause death or readmission, rather than Fried frailty phenotype. Frailty in gerontal SBHF inpatients deserves more attention.Clinical Trial registration: ChiCTR1800017204; date of registration: 07/18/2018.

scholarly journals Impact and risk factors for clinically relevant surgery-related muscle loss in patients after major abdominal cancer surgery: study protocol for a prospective observational cohort study (MUSCLE POWER)

2019 ◽  
Vol 6 (3) ◽  
pp. 138
Author(s):  
Judith E. K. R. Hentzen ◽  
Laura Van Wijk ◽  
Carlijn I. Buis ◽  
Alain R. Viddeleer ◽  
Geertruida H. De Bock ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cohort Study ◽  
Abdominal Surgery ◽  
Cancer Patients ◽  
Protein Intake ◽  
Muscle Power ◽  
Observational Cohort Study ◽  
Prospective Observational Cohort Study ◽  
Muscle Loss ◽  
Observational Cohort

<p class="abstract"><strong>Background:</strong> Surgery-related muscle loss (SRML) occurs in at least one out of three cancer patients within one week after major surgery. Though, this important phenomenon has hardly been investigated.</p><p class="abstract"><strong>Methods:</strong> The MUSCLE POWER is a prospective, observational cohort study that investigates the presence, impact, and predictors for clinically relevant SRML in 178 cancer patients after major abdominal surgery using ultrasound measurements, squeeze and force measurements, and QoL questionnaires. Primary endpoint is the proportion of patients with clinically relevant SRML defined as ≥5% muscle loss within one week after surgery, measured by the cross-sectional area (CSA) of three different muscles: m. biceps brachii, m. rectus femoris, and m. vastus intermedius. Possible correlation with QoL and fatigue up to six months after surgery will be investigated. Daily physical activity during hospital stay will be monitored by a motility tracker, and protein intake will be monitored by a dietician. Possible predictors for clinically relevant SRML—consisting of age ≥65 years, preoperative diabetes, preoperative sarcopenia, major postoperative complications (Clavien-Dindo ≥III), insufficient physical activity, and insufficient postoperative protein intake—will be investigated with a multivariable logistic regression analyses with a backward stepwise approach. Variables with a <em>p</em>&lt;0.05 will be retrained in the final multivariable model.</p><p class="abstract"><strong>Discussion: </strong>The MUSCLE POWER investigates the presence and impact of clinically relevant SRML in cancer patients after major abdominal surgery. Crucial information regarding possible predictors for clinically relevant SRML can be used in future intervention studies to prevent postoperative muscle loss and subsequently improve postoperative outcome and QoL.</p><p><strong>Trial Registration: </strong>Medical Ethics Committee of the University Medical Center Groningen, the Netherlands (METc2018/361, version 3.0, January 21, 2019), and Netherlands Trial Register ([NTR], NTR NL7505, version 1.0, February 7, 2019).</p>

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