scholarly journals Screening and clinical significance of lymph node metastasis‐related genes within esophagogastric junction adenocarcinoma

2021 ◽  
Author(s):  
Rui Han ◽  
Gang Chen ◽  
Meng Li ◽  
Zhong‐Min Peng ◽  
Lin Xu
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Clinical Significance ◽  
Esophagogastric Junction ◽  
Node Metastasis ◽  
Esophagogastric Junction Adenocarcinoma

Mo1231 LYMPH NODE METASTASIS RISK IN SUPERFICIAL ESOPHAGOGASTRIC JUNCTION ADENOCARCINOMA

2019 ◽  
Vol 89 (6) ◽  
pp. AB476
Author(s):  
Naoki Akazawa ◽  
Yoshimasa Horie ◽  
Atsuko Tamashiro ◽  
Yoshitaka Tokai ◽  
Sho Shiroma ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Esophagogastric Junction ◽  
Node Metastasis ◽  
Esophagogastric Junction Adenocarcinoma

Mediastinal lymph node metastasis and recurrence in adenocarcinoma of the esophagogastric junction

Surgery ◽  
2015 ◽  
Vol 157 (3) ◽  
pp. 551-555 ◽  
Author(s):  
Yukinori Kurokawa ◽  
Naoki Hiki ◽  
Takaki Yoshikawa ◽  
Kentaro Kishi ◽  
Yuichi Ito ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Esophagogastric Junction ◽  
Mediastinal Lymph Node ◽  
Mediastinal Lymph Node Metastasis ◽  
Node Metastasis

scholarly journals Expression of HIF-2αand VEGF in Cervical Squamous Cell Carcinoma and Its Clinical Significance

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Lixia Zhang ◽  
Qiang Chen ◽  
Jing Hu ◽  
Yue Chen ◽  
Chenglong Liu ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Clinical Significance ◽  
Systemic Disease ◽  
Cervical Squamous Cell Carcinoma ◽  
Control Group ◽  
Vegf Mrna ◽  
Node Metastasis ◽  
Figo Staging ◽  
Vegf Mrna Expression

CSCC is a systemic disease involving polygenic alteration and multiple steps, and HIF and VEGF are closely associated with tumorigenesis. Specimens surgically resected from 64 cases of CSCC and 22 cases of normal cervical tissue were selected randomly to detect the expression of HIF-2αand VEGF in CSCC for exploring their clinical significance; information regarding the age, lymph node metastasis, and FIGO staging were collected as well; expression of HIF-2αand VEGF was detected by qPCR and immunohistochemistry. We found that the expression of HIF-2αand VEGF mRNA in CSCC was significantly higher than that of normal cervical tissues and showed a positive correlation between them. The positive rates of HIF-2αand VEGF protein expression in CSCC and normal cervical tissues were 93.8% and 18.2%, respectively, with correlation between them. The expression of both HIF-2αand VEGF mRNA did not relate closely to age but the FIGO staging and lymph node metastasis. Compared with the counterpart control group, CSCC tissues with high FIGO staging and lymph node metastasis had a higher level of HIF-2αand VEGF mRNA expression. So, HIF-2αand VEGF were overexpressed in CSCC, which has a great clinical significance for its diagnosis.

scholarly journals Clinical significance of neutrophil-to-lymphocyte ratio as a predictor of lymph node metastasis in gastric cancer

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Toshiyuki Kosuga ◽  
Tomoki Konishi ◽  
Takeshi Kubota ◽  
Katsutoshi Shoda ◽  
Hirotaka Konishi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Clinical Significance ◽  
Characteristic Curve ◽  
Neutrophil To Lymphocyte Ratio ◽  
Youden Index ◽  
Lymphocyte Ratio ◽  
Node Metastasis ◽  
Higher Sensitivity

Abstract Background Precise staging is indispensable to select the appropriate treatment strategy for gastric cancer (GC); however, the diagnostic accuracy of conventional modalities needs to be improved. This study investigated the clinical significance of the preoperative neutrophil-to-lymphocyte ratio (NLR) for the prediction of pathological lymph node metastasis (pN+) in GC. Methods This was a retrospective study of 429 patients with GC who underwent curative gastrectomy. The predictive ability of NLR for pN+ was examined in comparison with that of computed tomography. Results The preoperative NLR ranged from 0.6 to 10.8 (median, 2.0), and the optimal cut-off value for predicting pN+ was 1.6 according to the receiver operating characteristic curve with the maximal Youden index. Multivariate analysis identified a NLR ≥ 1.6 (odds ratio (OR) 3.171; 95% confidence interval (CI) 1.448–7.235, p = 0.004) and cN+ (OR 2.426; 95% CI 1.221–4.958, p = 0.011) to be independent factors associated with pN+ in advanced GC (cT2-T4). On the other hand, a NLR ≥ 1.6 was not useful for predicting pN+ in early GC (cT1). In advanced GC, a NLR ≥ 1.6 detected pN+ with a higher sensitivity (84.9%) and negative predictive value (NPV) (63.9%) than conventional modalities (50.0 and 51.7%, respectively). When the subjects were limited to those with advanced GC with cN0, the sensitivity and NPV of a NLR ≥ 1.6 for pN+ increased further (90.7 and 81.0%, respectively). Conclusion The preoperative NLR may be a useful complementary diagnostic tool for predicting pN+ in advanced GC because of its higher sensitivity and NPV than conventional modalities.

VS01.06: THORACOSCOPIC EXTENDED LYMPHADENECTOMY FOR EGJ CANCER: AN OPTION TO LEARN FROM THE EAST

2018 ◽  
Vol 31 (Supplement_1) ◽  
pp. 45-45
Author(s):  
Simone Giacopuzzi ◽  
Jacopo Weindelmayer ◽  
Giovanni De Manzoni
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Recurrent Laryngeal Nerve ◽  
Esophagogastric Junction ◽  
Conflicts Of Interest ◽  
Laryngeal Nerve ◽  
Extended Lymphadenectomy ◽  
Node Dissection ◽  
Node Metastasis ◽  
The Right

Abstract Description Extended thoracoscopic lymphadenectomy is not common practice in Western countries in patients with adenocarcinoma of the esophagogastric junction. In this video we present a case of a patient with siewert I adenocarcinoma with lymph node metastasis to the right recurrent laryngeal nerve not treated with neoadjuvant therapy, due to comorbidity. The operation was: extended thoracoscopic en-block lymph node dissection. video will be edited in a more rigorous manner Disclosure All authors have declared no conflicts of interest.

scholarly journals Prognostic impact of Claudin 18.2 in gastric and esophageal adenocarcinomas

2020 ◽  
Vol 22 (12) ◽  
pp. 2357-2363
Author(s):  
A. Arnold ◽  
S. Daum ◽  
M. von Winterfeld ◽  
E. Berg ◽  
M. Hummel ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Distant Metastasis ◽  
Esophagogastric Junction ◽  
Epithelial Tissue ◽  
Prognostic Impact ◽  
Tumor Subtype ◽  
Primary Tumors ◽  
Node Metastasis ◽  
Therapy Target

Abstract Introduction The tight junction molecule Claudin 18.2 is selectively expressed in healthy and malignant gastric epithelial tissue and is a promising therapy target for high Claudin 18.2 expressing adenocarcinomas of the esophagogastric junction and stomach (AEG/S). Methods This study analyzed the prevalence, characteristics and prognostic impact of Claudin 18.2 expression in primary tumor, lymph node and distant metastasis in a large Caucasian AGE/S cohort with 414 patients. Results Claudin 18.2 was highly expressed in 17.1% of primary tumors, 26.7% of lymph node metastasis and 16.7% of distant metastasis. High Claudin 18.2 expression in lymph node metastasis and primary tumors correlated significantly (p < 0.001). High expression of Claudin 18.2 was neither associated with histomorphogical subtype, or tumor state, nor with overall survival. Conclusion In Caucasian AEG/S patients, 17.1% appeared to be eligible for an anti-Claudin 18.2 therapy. Claudin 18.2 expression itself has no impact on prognosis and is not related to any tumor subtype.

Mapping of Lymph Node Metastasis From Esophagogastric Junction Tumors

2019 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Yukinori Kurokawa ◽  
Hiroya Takeuchi ◽  
Yuichiro Doki ◽  
Shinji Mine ◽  
Masanori Terashima ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Esophagogastric Junction ◽  
Node Metastasis

Periprostatic lymph node metastasis in prostate cancer and its clinical significance

2012 ◽  
Vol 60 (6) ◽  
pp. 1004-1008 ◽  
Author(s):  
Fang-Ming Deng ◽  
Savvas E Mendrinos ◽  
Kasturi Das ◽  
Jonathan Melamed
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Clinical Significance ◽  
Node Metastasis
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