scholarly journals Development and validation of MRI‐based deep learning models for prediction of microsatellite instability in rectal cancer

2021 ◽  
Author(s):  
Wei Zhang ◽  
Hongkun Yin ◽  
Zixing Huang ◽  
Jian Zhao ◽  
Haoyu Zheng ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Deep Learning ◽  
Microsatellite Instability ◽  
Learning Models ◽  
Development And Validation

MRI-Based Deep Learning Analysis Can Predict Microsatellite Instability in Rectal Cancer

2020 ◽  
Author(s):  
Wei Zhang ◽  
Zixing Huang ◽  
Jian Zhao ◽  
Du He ◽  
Mou Li ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Deep Learning ◽  
Microsatellite Instability ◽  
Learning Analysis

scholarly journals Development and Validation of Deep Learning Models for Screening Multiple Abnormal Findings in Retinal Fundus Images

Ophthalmology ◽  
2020 ◽  
Vol 127 (1) ◽  
pp. 85-94 ◽  
Author(s):  
Jaemin Son ◽  
Joo Young Shin ◽  
Hoon Dong Kim ◽  
Kyu-Hwan Jung ◽  
Kyu Hyung Park ◽  
...  
Keyword(s):  
Deep Learning ◽  
Fundus Images ◽  
Learning Models ◽  
Retinal Fundus Images ◽  
Development And Validation ◽  
Retinal Fundus

Development and Validation of Image-Based Deep Learning Models to Predict Surgical Complexity and Complications in Abdominal Wall Reconstruction

JAMA Surgery ◽  
2021 ◽  
Author(s):  
Sharbel Adib Elhage ◽  
Eva Barbara Deerenberg ◽  
Sullivan Armando Ayuso ◽  
Keith Joseph Murphy ◽  
Jenny Meng Shao ◽  
...  
Keyword(s):  
Deep Learning ◽  
Abdominal Wall ◽  
Abdominal Wall Reconstruction ◽  
Learning Models ◽  
Surgical Complexity ◽  
Development And Validation

Levenshtein Augmentation Improves Performance of SMILES Based Deep-Learning Synthesis Prediction

2020 ◽  
Author(s):  
Dean Sumner ◽  
Jiazhen He ◽  
Amol Thakkar ◽  
Ola Engkvist ◽  
Esben Jannik Bjerrum
Keyword(s):  
Neural Networks ◽  
Pattern Recognition ◽  
Deep Learning ◽  
Recurrent Neural Networks ◽  
Data Augmentation ◽  
State Of The Art ◽  
Sequence Similarity ◽  
Learning Models ◽  
Underlying Network

<p>SMILES randomization, a form of data augmentation, has previously been shown to increase the performance of deep learning models compared to non-augmented baselines. Here, we propose a novel data augmentation method we call “Levenshtein augmentation” which considers local SMILES sub-sequence similarity between reactants and their respective products when creating training pairs. The performance of Levenshtein augmentation was tested using two state of the art models - transformer and sequence-to-sequence based recurrent neural networks with attention. Levenshtein augmentation demonstrated an increase performance over non-augmented, and conventionally SMILES randomization augmented data when used for training of baseline models. Furthermore, Levenshtein augmentation seemingly results in what we define as <i>attentional gain </i>– an enhancement in the pattern recognition capabilities of the underlying network to molecular motifs.</p>

Improving the Accuracy of Protein-Ligand Binding Affinity Prediction by Deep Learning Models: Benchmark and Model

2019 ◽  
Author(s):  
Mohammad Rezaei ◽  
Yanjun Li ◽  
Xiaolin Li ◽  
Chenglong Li
Keyword(s):  
Deep Learning ◽  
Drug Design ◽  
Binding Affinity ◽  
Benchmark Dataset ◽  
Rational Drug Design ◽  
Learning Models ◽  
Structure Based Drug Design ◽  
Binding Affinity Prediction ◽  
Affinity Prediction ◽  
Rational Drug

<b>Introduction:</b> The ability to discriminate among ligands binding to the same protein target in terms of their relative binding affinity lies at the heart of structure-based drug design. Any improvement in the accuracy and reliability of binding affinity prediction methods decreases the discrepancy between experimental and computational results.<br><b>Objectives:</b> The primary objectives were to find the most relevant features affecting binding affinity prediction, least use of manual feature engineering, and improving the reliability of binding affinity prediction using efficient deep learning models by tuning the model hyperparameters.<br><b>Methods:</b> The binding site of target proteins was represented as a grid box around their bound ligand. Both binary and distance-dependent occupancies were examined for how an atom affects its neighbor voxels in this grid. A combination of different features including ANOLEA, ligand elements, and Arpeggio atom types were used to represent the input. An efficient convolutional neural network (CNN) architecture, DeepAtom, was developed, trained and tested on the PDBbind v2016 dataset. Additionally an extended benchmark dataset was compiled to train and evaluate the models.<br><b>Results: </b>The best DeepAtom model showed an improved accuracy in the binding affinity prediction on PDBbind core subset (Pearson’s R=0.83) and is better than the recent state-of-the-art models in this field. In addition when the DeepAtom model was trained on our proposed benchmark dataset, it yields higher correlation compared to the baseline which confirms the value of our model.<br><b>Conclusions:</b> The promising results for the predicted binding affinities is expected to pave the way for embedding deep learning models in virtual screening and rational drug design fields.

Data science in economics: comprehensive review of advanced machine learning and deep learning methods

2020 ◽  
Author(s):  
Saeed Nosratabadi ◽  
Amir Mosavi ◽  
Puhong Duan ◽  
Pedram Ghamisi ◽  
Ferdinand Filip ◽  
...  
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Data Science ◽  
State Of The Art ◽  
Science Methods ◽  
Learning Models ◽  
Diverse Range ◽  
Hybrid Machine ◽  
Economics Research

This paper provides a state-of-the-art investigation of advances in data science in emerging economic applications. The analysis was performed on novel data science methods in four individual classes of deep learning models, hybrid deep learning models, hybrid machine learning, and ensemble models. Application domains include a wide and diverse range of economics research from the stock market, marketing, and e-commerce to corporate banking and cryptocurrency. Prisma method, a systematic literature review methodology, was used to ensure the quality of the survey. The findings reveal that the trends follow the advancement of hybrid models, which, based on the accuracy metric, outperform other learning algorithms. It is further expected that the trends will converge toward the advancements of sophisticated hybrid deep learning models.

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