scholarly journals The oncogenic role of the cerebral endothelial cell adhesion molecule (CERCAM) in bladder cancer cells in vitro and in vivo

2021 ◽  
Author(s):  
Yali Zuo ◽  
Xiaoliang Xu ◽  
Minfeng Chen ◽  
Lin Qi
Keyword(s):  
Bladder Cancer ◽  
Cell Adhesion ◽  
Endothelial Cell ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Bladder Cancer Cells ◽  
Endothelial Cell Adhesion

scholarly journals Soluble Domain 1 of Platelet–Endothelial Cell Adhesion Molecule (PECAM) Is Sufficient to Block Transendothelial Migration In Vitro and In Vivo

1997 ◽  
Vol 185 (7) ◽  
pp. 1349-1358 ◽  
Author(s):  
Fang Liao ◽  
Jahanara Ali ◽  
Tricia Greene ◽  
William A. Muller
Keyword(s):  
Cell Adhesion ◽  
Endothelial Cell ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Transendothelial Migration ◽  
Endothelial Cell Adhesion Molecule ◽  
Platelet Endothelial Cell Adhesion ◽  
Endothelial Cell Adhesion

The inflammatory response involves sequential adhesive interactions between cell adhesion molecules of leukocytes and the endothelium. Unlike the several adhesive steps that precede it, transendothelial migration (diapedesis), the step in which leukocytes migrate between apposed endothelial cells, appears to involve primarily one adhesion molecule, platelet–endothelial cell adhesion molecule (PECAM, CD31). Therefore, we have focused on PECAM as a target for antiinflammatory therapy. We demonstrate that soluble chimeras made of the entire extracellular portion of PECAM, or of only the first immunoglobulin domain of PECAM, fused to the Fc portion of IgG, block diapedesis in vitro and in vivo. Furthermore, the truncated form of the PECAM-IgG chimera does not bind stably to its cellular ligand. This raises the possibility of selective anti-PECAM therapies that would not have the untoward opsonic or cell-activating properties of antibodies directed against PECAM.

Role of different nitric oxide synthese (NOS) isoforms in the regulation of endothelial cell adhesion molecule (ECAM) expression in vivo

2000 ◽  
Vol 118 (4) ◽  
pp. A827 ◽  
Author(s):  
Shigeyuki Kawachi ◽  
David J. Leffer ◽  
Henri C. Van Der Heyde ◽  
Stephen Laroux ◽  
Laura Gray ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cell Adhesion ◽  
Endothelial Cell ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Endothelial Cell Adhesion Molecule ◽  
Nos Isoforms ◽  
Endothelial Cell Adhesion
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