scholarly journals Expression and ERG regulation of PIM kinases in prostate cancer

2021 ◽  
Author(s):  
Sini K. Eerola ◽  
Annika Kohvakka ◽  
Teuvo L. J. Tammela ◽  
Päivi J. Koskinen ◽  
Leena Latonen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Pim Kinases

scholarly journals PO-095 PIM kinases in the regulation of prostate cancer cell motility

2018 ◽  
Author(s):  
N Santio ◽  
V Vainio ◽  
M Lång ◽  
KL Mung ◽  
J Heino ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Motility ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Motility ◽  
Pim Kinases

Abstract 1096: Co-targeting of AKT and Pim kinases in mousePTEN-deficient prostate cancer

2017 ◽  
Author(s):  
Marco A. De Velasco ◽  
Koichi Sugimoto ◽  
Yurie Kura ◽  
Naomi Ando ◽  
Noriko Sato ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Pim Kinases

scholarly journals Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes

2009 ◽  
Vol 8 (10) ◽  
pp. 2882-2893 ◽  
Author(s):  
Shannon M. Mumenthaler ◽  
Patricia Y.B. Ng ◽  
Amanda Hodge ◽  
David Bearss ◽  
Gregory Berk ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Growth ◽  
Pim Kinases ◽  
Pharmacologic Inhibition

scholarly journals Phosphorylation of NFATC1 at PIM1 target sites is essential for its ability to promote prostate cancer cell migration and invasion

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Sini K. Eerola ◽  
Niina M. Santio ◽  
Sanni Rinne ◽  
Petri Kouvonen ◽  
Garry L. Corthals ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Transcriptional Activity ◽  
Prostate Cancer Cell ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Wild Type ◽  
Pim Kinases ◽  
Target Sites

Abstract Background Progression of prostate cancer from benign local tumors to metastatic carcinomas is a multistep process. Here we have investigated the signaling pathways that support migration and invasion of prostate cancer cells, focusing on the role of the NFATC1 transcription factor and its post-translational modifications. We have previously identified NFATC1 as a substrate for the PIM1 kinase and shown that PIM1-dependent phosphorylation increases NFATC1 activity without affecting its subcellular localization. Both PIM kinases and NFATC1 have been reported to promote cancer cell migration, invasion and angiogenesis, but it has remained unclear whether the effects of NFATC1 are phosphorylation-dependent and which downstream targets are involved. Methods We used mass spectrometry to identify PIM1 phosphorylation target sites in NFATC1, and analysed their functional roles in three prostate cancer cell lines by comparing phosphodeficient mutants to wild-type NFATC1. We used luciferase assays to determine effects of phosphorylation on NFAT-dependent transcriptional activity, and migration and invasion assays to evaluate effects on cell motility. We also performed a microarray analysis to identify novel PIM1/NFATC1 targets, and validated one of them with both cellular expression analyses and in silico in clinical prostate cancer data sets. Results Here we have identified ten PIM1 target sites in NFATC1 and found that prevention of their phosphorylation significantly decreases the transcriptional activity as well as the pro-migratory and pro-invasive effects of NFATC1 in prostate cancer cells. We observed that also PIM2 and PIM3 can phosphorylate NFATC1, and identified several novel putative PIM1/NFATC1 target genes. These include the ITGA5 integrin, which is differentially expressed in the presence of wild-type versus phosphorylation-deficient NFATC1, and which is coexpressed with PIM1 and NFATC1 in clinical prostate cancer specimens. Conclusions Based on our data, phosphorylation of PIM1 target sites stimulates NFATC1 activity and enhances its ability to promote prostate cancer cell migration and invasion. Therefore, inhibition of the interplay between PIM kinases and NFATC1 may have therapeutic implications for patients with metastatic forms of cancer. Graphical abstract

scholarly journals Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells

Oncotarget ◽  
2016 ◽  
Vol 7 (28) ◽  
pp. 43220-43238 ◽  
Author(s):  
Niina M. Santio ◽  
Sebastian K.-J. Landor ◽  
Laura Vahtera ◽  
Jani Ylä-Pelto ◽  
Elina Paloniemi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Oncogenic Signaling ◽  
Pim Kinases ◽  
Breast And Prostate Cancer

scholarly journals Pim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0130340 ◽  
Author(s):  
Niina M. Santio ◽  
Sini K. Eerola ◽  
Ilkka Paatero ◽  
Jari Yli-Kauhaluoma ◽  
Fabrice Anizon ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Pim Kinases ◽  
Metastatic Growth

Sigmoidoscopic findings following radiation for prostate cancer

2001 ◽  
Vol 120 (5) ◽  
pp. A284-A284
Author(s):  
T BOLIN ◽  
A KNEEBONE ◽  
T LARSSON
Keyword(s):  
Prostate Cancer

1625: Neuroligin 4 ISOFORM Y: A Novel Marker for Prostate Cancer

2007 ◽  
Vol 177 (4S) ◽  
pp. 538-539
Author(s):  
Joseph F. Pazona ◽  
C. Shad Thaxton ◽  
Neema Navai ◽  
Brian T. Helfand ◽  
Lee C. Zhao ◽  
...  
Keyword(s):  
Prostate Cancer

232: Natural History of Treated Biochemical Recurrence after Radical Prostatectomy for Prostate Cancer

2007 ◽  
Vol 177 (4S) ◽  
pp. 77-78
Author(s):  
Christopher R. Porter ◽  
Jochen Walz ◽  
Andrea Gallina ◽  
Claudio Jeldres ◽  
Koichi Kodama ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Natural History ◽  
Biochemical Recurrence ◽  
History Of
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