scholarly journals Zerumbone increases oxidative stress in a thiol‐dependent ROS ‐independent manner to increase DNA damage and sensitize colorectal cancer cells to radiation

2014 ◽  
Vol 4 (2) ◽  
pp. 278-292 ◽  
Author(s):  
Amit Deorukhkar ◽  
Niharika Ahuja ◽  
Armando‐Lopez Mercado ◽  
Parmeswaran Diagaradjane ◽  
Uma Raju ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Colorectal Cancer ◽  
Dna Damage ◽  
Cancer Cells ◽  
Independent Manner ◽  
Colorectal Cancer Cells

scholarly journals Interleukin-6 promotes dietary carcinogen-induced DNA damage in colorectal cancer cells

2015 ◽  
Vol 4 (4) ◽  
pp. 858-866 ◽  
Author(s):  
Saroor A. A. Patel ◽  
Nigel J. Gooderham
Keyword(s):  
Colorectal Cancer ◽  
Dna Damage ◽  
Cancer Cells ◽  
Interleukin 6 ◽  
Inflammatory Cytokine ◽  
Cultured Cells ◽  
Colorectal Cancer Cells ◽  
2D And 3D

Pro-inflammatory cytokine interleukin-6 promotes dietary carcinogen-mediated DNA damage in 2D and 3D cultured cells by inducingCYP1B1expression through miR27b downregulation.

Abstract 3031: Replication stress and DNA damage promote genomic instability in near-tetraploid colorectal cancer cells

2015 ◽  
Author(s):  
Isabel Quintanilla ◽  
Darawalee Wangsa ◽  
Markus Brown ◽  
Amaia Ercilla ◽  
Greg Klus ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Damage ◽  
Cancer Cells ◽  
Genomic Instability ◽  
Replication Stress ◽  
Colorectal Cancer Cells

Oxidative stress causes epigenetic alteration of CDX1 expression in colorectal cancer cells

Gene ◽  
2013 ◽  
Vol 524 (2) ◽  
pp. 214-219 ◽  
Author(s):  
Rui Zhang ◽  
Kyoung Ah Kang ◽  
Ki Cheon Kim ◽  
Soo-Young Na ◽  
Weon Young Chang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Colorectal Cancer ◽  
Cancer Cells ◽  
Epigenetic Alteration ◽  
Colorectal Cancer Cells

scholarly journals Correction: Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation

Oncotarget ◽  
2020 ◽  
Vol 11 (3) ◽  
pp. 302-303
Author(s):  
Jie Zhang ◽  
Pengxing He ◽  
Yong Xi ◽  
Meiyu Geng ◽  
Yi Chen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Damage ◽  
Cancer Cells ◽  
Dna Damage Response ◽  
Down Regulation ◽  
Colorectal Cancer Cells ◽  
Damage Response

scholarly journals TBX3 acts as tissue-specific component of the Wnt/β-catenin transcriptional complex

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Dario Zimmerli ◽  
Costanza Borrelli ◽  
Amaia Jauregi-Miguel ◽  
Simon Söderholm ◽  
Salome Brütsch ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Target Genes ◽  
Regulatory Elements ◽  
Dependent Manner ◽  
Independent Manner ◽  
Tissue Specific ◽  
Colorectal Cancer Cells ◽  
Transcriptional Complex

BCL9 and PYGO are β-catenin cofactors that enhance the transcription of Wnt target genes. They have been proposed as therapeutic targets to diminish Wnt signaling output in intestinal malignancies. Here we find that, in colorectal cancer cells and in developing mouse forelimbs, BCL9 proteins sustain the action of β-catenin in a largely PYGO-independent manner. Our genetic analyses implied that BCL9 necessitates other interaction partners in mediating its transcriptional output. We identified the transcription factor TBX3 as a candidate tissue-specific member of the β-catenin transcriptional complex. In developing forelimbs, both TBX3 and BCL9 occupy a large number of Wnt-responsive regulatory elements, genome-wide. Moreover, mutations in Bcl9 affect the expression of TBX3 targets in vivo, and modulation of TBX3 abundance impacts on Wnt target genes transcription in a β-catenin- and TCF/LEF-dependent manner. Finally, TBX3 overexpression exacerbates the metastatic potential of Wnt-dependent human colorectal cancer cells. Our work implicates TBX3 as context-dependent component of the Wnt/β-catenin-dependent transcriptional complex.

846: Antitumor activity of the synthetic retinoid ST1926 in colorectal cancer cells: involvement of DNA damage

2014 ◽  
Vol 50 ◽  
pp. S206
Author(s):  
N. Darwiche ◽  
R. Abdel-Samad ◽  
R. Hmadi ◽  
M. El-Sabban ◽  
H. Muhtasib ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Damage ◽  
Antitumor Activity ◽  
Cancer Cells ◽  
Synthetic Retinoid ◽  
Colorectal Cancer Cells

scholarly journals Growth hormone protects colorectal cancer cells from radiation by improving the ability of DNA damage repair

2014 ◽  
Vol 10 (1) ◽  
pp. 486-490 ◽  
Author(s):  
XIAO-YU WU ◽  
CHE CHEN ◽  
XUE-QUAN YAO ◽  
QIN-HONG CAO ◽  
ZHE XU ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Growth Hormone ◽  
Dna Damage ◽  
Cancer Cells ◽  
Dna Damage Repair ◽  
Damage Repair ◽  
Colorectal Cancer Cells
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