scholarly journals Risk factors and their diagnostic values for ocular metastases in invasive ductal carcinoma

2020 ◽  
Author(s):  
Rong‐Bin Liang ◽  
Kang Yu ◽  
Jie‐Li Wu ◽  
Jia‐Xiang Liu ◽  
Qi Lin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Diagnostic Values ◽  
Ocular Metastases

scholarly journals Circulating RP11-445H22.4 and TINCR are Potential Biomarkers for Invasive Ductal Carcinoma of the Breast

2020 ◽  
Author(s):  
Mohammad-Taher Moradi ◽  
Zohreh Rahimi
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Promoter Methylation ◽  
Ductal Carcinoma ◽  
Specific Pcr ◽  
Tumor Tissues ◽  
Potential Biomarker ◽  
Relative Quantitation ◽  
Diagnostic Values ◽  
Polymerase Chain ◽  
Potential Biomarkers

Introduction: Invasive ductal carcinoma (IDC) is a frequently observed type of breast cancer. Moreover, it has been demonstrated that long non-coding RNAs (lncRNAs) are associated with various diseases, including cancer, and they may have the potential to act as biomarkers. Methods. The relative quantitation (RQ) of two lncRNAs, RP11-445H22.4 and TINCR, was measured in tumoral tissues and paired adjacent non-tumoral tissues (PANTs) as well as in plasma samples using real-time polymerase chain reaction (RT-PCR). Furthermore, promoter methylation of the two lncRNAs genes was assessed using methylation-specific PCR (MSP). In order to compare the diagnostic values, plasma levels of CA 15-3 were measured as a conventional circulating biomarker using ELISA. The receiver operating characteristic (ROC) curve was used to illustrate the sensitivity and specificity of the potential biomarkers. Results. The RP11-445H22.4 and TINCR genes were upregulated in tumor tissues compared to PANTs (RQRP11-445H22.4 = 2.7, RQTINCR = 4.4). Furthermore, the presence of RP11-445H22.4 and TINCR in the plasma of patients was significantly more than healthy controls (RQc.RP11-445H22.4 = 4.12, RQc.TINCR = 4.16, P<0.001). The promoters of RP11-445H22.4 and TINCR genes were hypomethylated in the tumoral tissues with a negative correlation with their gene expression. Conclusion. Based on the findings, it can be speculated that the expression levels of these two lncRNAs as well as their promoter methylation can be considered as a therapeutic target and potential biomarker for breast carcinoma.

scholarly journals Circulating RP11-445H22.4 and TINCR are Potential Biomarkers for Invasive Ductal Carcinoma of the Breast

2021 ◽  
Author(s):  
Mohammad-Taher Moradi ◽  
Zohreh Rahimi
Keyword(s):  
Breast Cancer ◽  
Invasive Ductal Carcinoma ◽  
Promoter Methylation ◽  
Ductal Carcinoma ◽  
Specific Pcr ◽  
Potential Biomarker ◽  
Relative Quantitation ◽  
Diagnostic Values ◽  
Circulating Markers ◽  
Potential Biomarkers

Abstract Background: Recently introduced molecules namely long non-coding RNAs (lncRNAs) are associated with various diseases, including breast cancer, and they may have the potential to act as biomarkers. Invasive ductal carcinoma (IDC) is a frequently observed type of breast cancer that diagnosis through immunohistochemical methods. However, no reliable non-invasive markers such as circulating markers have been introduced for it, so far. Methods: The relative quantitation (RQ) of two lncRNAs, RP11-445H22.4 and TINCR, was measured in tumoral tissues and paired adjacent non-tumoral tissues (PANTs) as well as in plasma samples using real-time polymerase chain reaction (RT-PCR). Furthermore, promoter methylation of the two lncRNAs genes was assessed using methylation-specific PCR (MSP). In order to compare the diagnostic values, plasma levels of CA 15-3 were measured as a conventional circulating biomarker using ELISA. The receiver operating characteristic (ROC) curve was used to illustrate the sensitivity and specificity of the potential biomarkers. Results: The RP11-445H22.4 and TINCR genes were upregulated in tumor tissues compared to PANTs (RQRP11-445H22.4 = 2.7, RQTINCR = 4.4). Furthermore, the presence of RP11-445H22.4 and TINCR in the plasma of patients was significantly more than healthy controls (RQc.RP11-445H22.4 = 4.12, RQc.TINCR = 4.16, P<0.001). The promoters of RP11-445H22.4 and TINCR genes were hypomethylated in the tumoral tissues with a negative correlation with their gene expression. Conclusion: Based on the findings, it can be speculated that the expression levels of these two lncRNAs, as well as their promoter methylation, can be considered as a therapeutic target and potential biomarker for breast carcinoma.

scholarly journals Risk Factors and Their Diagnostic Values for Ocular Metastases in Gastric Adenocarcinoma

2021 ◽  
Vol Volume 13 ◽  
pp. 5835-5843
Author(s):  
Yue Chen ◽  
Yan-Chang Yang ◽  
Li-Ying Tang ◽  
Qian-Min Ge ◽  
Wen-Qing Shi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Adenocarcinoma ◽  
Diagnostic Values ◽  
Ocular Metastases

Ultrasonographic findings of 46 resected cases with invasive ductal carcinoma of the pancreas within 20 mm in size

Choonpa Igaku ◽  
2018 ◽  
Vol 45 (3) ◽  
pp. 301-309 ◽  
Author(s):  
Sachiko KOBAYASHI ◽  
Shigeyuki HASUO ◽  
Motoi MIYAKOSHI ◽  
Tomohiro NAKATANI ◽  
Yukie NAKAJIMA ◽  
...  
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Carcinoma Of The Pancreas
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